Results 201 to 210 of about 23,167 (255)

Refining the Genetic Contribution to Type 2 Diabetes Subtypes

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Type 2 diabetes (T2D) is a complex and highly heterogeneous disease driven in part by genetic predisposition and can be stratified into clinical subgroups to aid disease management. We recently grouped T2D subjects in the Qatar Biobank (QBB) cohort into Severe Insulin‐Deficient Diabetes (SIDD), Severe Insulin‐Resistant Diabetes ...
Nayra M. Al‐Thani, Salman M. Toor, Umm‐Kulthum Ismail Umlai, Usama Aliyu, Karsten Suhre, Omar M. E. Albagha   +5 more
wiley   +1 more source

A preclinical investigation into the potential associations of geraniin with ulcerative colitis alleviation through integrated multi-omics and <i>in vivo</i> analysis. [PDF]

Front Med (Lausanne)
Cheng C, Wang W, Zheng T, Shi X, Fu C.
europepmc   +1 more source

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

<i>Primula nutans</i> Georgi Extract Inhibits Early Adipogenesis Through CHOP-Associated Regulation and Ameliorates Obesity and Insulin Resistance. [PDF]

Int J Mol Sci
Roh N, Park K, Le D, Kim E, Dang T, Dinh T, Bazarragchaa B, Kim SY, Suh SS, Kim JJ, Lee M, Seo JB.   +11 more
europepmc   +1 more source

Tankyrase‐2 regulates adipocyte differentiation through AMPK/mTOR signaling

The FEBS Journal, EarlyView.
Tankyrase 2 (TNKS2), a PARP family member, underpins adipocyte differentiation. TNKS2 controls LKB1 protein level, and consequently, the activity of the mTOR/AMPK system and adipocyte differentiation through a layered process. Pharmacological inhibition of TNKS2 leaves other PARPs and DNA repair active and therefore represents a novel target in ...
Boglarka Rauch, Gyula Ujlaki, Szilard Poliska, Nakayi Murahwa, Patrik Kovacs, Aladar Pettko‐Szandtner, Karen Uray, Peter Bai   +7 more
wiley   +1 more source

Validating the potential mechanism and therapeutic effect of Qinlian Jiangxia decoction in the treatment of type 2 diabetes mellitus complicated with hyperlipidemia through network pharmacology, molecular docking, molecular dynamics simulation, andexperiments. [PDF]

J Tradit Chin Med
Zonghao R, Rensong Y.
europepmc   +1 more source

Correction: Glucocorticoid receptor inhibits Th2 immune responses by down-regulating Pparg and Gata3 in schistosomiasis. [PDF]

Front Immunol
Sun T, Bi X, Yang N, Zhang X, Chu J, Li L, Liu H, Tang R, Lin R.   +8 more
europepmc   +1 more source

ACSS2 governs milk fat synthesis in buffalo via a reciprocal positive feedback loop with SREBP1 and PPARG. [PDF]

Anim Biosci
Huang L, Wang R, Zhou F, Gao R, Fan X, Miao Y.   +5 more
europepmc   +1 more source

Immunometabolic transcriptomic signatures of diabetes-related genes predict kidney transplant rejection. [PDF]

Ren Fail
Casale R, Dello Strologo A, Alfieri C, Grandaliano G, Pesce F.   +4 more
europepmc   +1 more source

Spatial transcriptional mapping reveals the molecular characteristics of juxtaglomerular cell tumors. [PDF]

Front Oncol
Li J, Luo H, Wang Y, Zhu J, Zhao J, Sun B, Yang Z, Zheng J, Song Y, Fang Z.   +9 more
europepmc   +1 more source