Results 191 to 200 of about 23,167 (255)

Systems-Level Transcriptomic Integration Reveals a Core Metaflammatory Network Linking Type 2 Diabetes and HBV Infection to Cholangiocarcinoma Progression. [PDF]

Cancers (Basel)
Md Rasadul H, Ma S, Ge Z, Md Zahidur R, Kang P, You J, Li J, Duan C, Fahim SAZM, Somrat Akbor M, Zhao X, Cui Y.   +11 more
europepmc   +1 more source

Targeting Egfr‐Mediated Cell Proliferation and Lipid Metabolism Separation Effectively Accelerate Liver Regeneration

Cell Proliferation, EarlyView.
AREG coordinates cell proliferation and lipid metabolism reprogramming during liver regeneration and targeting lipid metabolism can promote liver regeneration. ABSTRACT Hepatocyte proliferation restores liver mass after partial hepatectomy (PHx), but the metabolic cost of this process remains unclear.
Yuelei Hu, Shifei Song, Ruilin Wang, Ni An, Jinmei Diao, Yuguo Chen, Juan Liu, Guoyue Lv   +7 more
wiley   +1 more source

Maternal obesity alters adipogenic potential and mitochondrial maximal respiration in infant mesenchymal stem cells. [PDF]

Front Endocrinol (Lausanne)
Paz HA, Zhong Y, Williams DK, Shankar K, Andres A, Wankhade UD.   +5 more
europepmc   +1 more source

Macrophage Lipid Homeostasis Drives IVDD via a Senescence‐Dependent Impairment of Efferocytosis

Cell Proliferation, EarlyView.
Intervertebral disc degeneration (IVDD) has been a leading cause of low back pain and lacks disease‐modifying therapies. Although dysregulated disc lipid metabolism is implicated, its impact on the immune microenvironment, particularly macrophages, remains unknown.
Jinyu Wang, Shiyong Ling, Qi Wang, Xuege Qiao, Jianpeng Xing, Siyang Ji, Linhui Han, Chen Yan, Zhishen Niu, Lei Yuan, Baolian Zhao, Kaiqiang Sun, Jiangang Shi   +12 more
wiley   +1 more source

Transient SUMOylation inhibition in human pre-adipocytes stably imprints a transcriptional beiging fate. [PDF]

Nucleic Acids Res
Nothnagel PMC, Meslin PA, Wik JA, Dufour D, Strøm YE, Bjørås M, Enserink JM, Skålhegg BS, Briand N, Mathelier A, Chymkowitch P.   +10 more
europepmc   +1 more source

Loss of peroxisomal membrane proteins PEX13 and PEX14 disrupts fatty acid oxidation and drives lipid imbalance. [PDF]

Biosci Rep
Vinoy N, Huang G, Wallace D, Subramaniam VN.   +3 more
europepmc   +1 more source

Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling

Cytopathology, EarlyView.
Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu, Mokhtar Abdelhammed, Xu Cao, Nisha S. Ramani   +3 more
wiley   +1 more source

Hnf1aos1 as a Metabolic Coordinator of Hepatic Lipid Homeostasis and Feedback Control. [PDF]

Noncoding RNA
Armanios B, Jin J, Laddha AP, Nguyen LTG, Tawfik SM, Mishra N, Manautou JE, Zhong XB.   +7 more
europepmc   +1 more source

Efficacy and Safety of SGLT2 Inhibitors in Patients With Genetic Lipodystrophy: A Real‐Life Experience From a National Reference Network

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim Lipodystrophy syndromes are rare diseases with metabolic and cardiovascular consequences. This study explores the metabolic and renal effects of sodium‐glucose cotransporter 2 inhibitors (SGLT2i) in patients with genetic lipodystrophy. Patients and Methods Patients with familial partial lipodystrophy (n = 57) or congenital generalised ...
Léna Robert, Ines Belalem, Corinne Vigouroux, Hippolyte Dupuis, Marie Christine Vantyghem, Mathilde Simonson, Estelle Nobecourt, Héléna Mosbah, Sophie Beliard, Stéphanie Jellimann, Sonja Janmaat, Camille Vatier, Sophie Lamothe   +12 more
wiley   +1 more source

A Novel PPARG R212W Variant Causes Familial Partial Lipodystrophy Type 3: Clinical Presentation and Functional Characterization. [PDF]

Int J Mol Sci
Gao Y, Song N, Fu L, Liang Y, Luo X.
europepmc   +1 more source