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Deciphering the role of gut microbiota metabolites in bronchiectasis through the perspectives of network pharmacology, Mendelian randomization, and molecular dynamics. [PDF]

Medicine (Baltimore)
Zhang Q, Li S, Zheng S, Tang J, Huang H, Han J, Zhou Y, Liu Y, Wu X, Luo J, Kong J.   +10 more
europepmc   +1 more source

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Small cell lung cancer with SYN2::PPARG fusion

Pathology - Research and Practice, 2023
Small cell lung cancer (SCLC) accounts for 15% of lung cancers worldwide. It is an aggressive tumor that is typically diagnosed at an advanced stage. Treatment involves chemo-immunotherapy and/or radiotherapy. Identifying druggable targets activated by specific genetic alterations represents a significant challenge in improving patient outcomes.We ...
M R, Ghigna, S, Cotteret, A, Arbab, M A, Bani, J Y, Scoazec   +4 more
openaire   +2 more sources

PPARG expression patterns and correlations in obesity

Journal of King Saud University - Science, 2022
Noura M Darwish
exaly   +2 more sources

Muscle-specific Pparg deletion causes insulin resistance

Nature Medicine, 2003
Thiazolidinediones (TZDs) are insulin-sensitizing drugs and are potent agonists of the nuclear peroxisome proliferator-activated receptor-gamma (PPAR-gamma). Although muscle is the major organ responsible for insulin-stimulated glucose disposal, PPAR-gamma is more highly expressed in adipose tissue than in muscle. To address this issue, we used the Cre-
Hevener, A L, He, W, Barak, Y, Le, J, Bandyopadhyay, G, Olson, P, Wilkes, J, Evans, R M, Olefsky, J   +8 more
openaire   +2 more sources

PPARG Gene Polymorphism and Locomotor Activity in Humans

Bulletin of Experimental Biology and Medicine, 2008
The distribution of PPARG gene allele frequencies (Pro/Ala polymorphism) was studied in sportsmen specialized in speed and force athletics. A relationship between genotypes and human muscle transverse section area was evaluated. The PPARG Ala allele was significantly more incident in athletes than in controls, the incidence increasing with higher ...
I I, Ahmetov, I A, Mozhayskaya, E V, Lyubaeva, O L, Vinogradova, V A, Rogozkin   +4 more
openaire   +2 more sources

PPARG Locus Haplotype Variation and Exacerbations in Asthma

Clinical Pharmacology & Therapeutics, 2007
The peroxisome proliferator-activated receptor gamma (PPARgamma) regulates inflammation and may play a role in asthma. Using mouthwash-derived DNA and clinical interviews and measurements, we investigated the association of previously characterized single-nucleotide polymorphisms in the PPARG gene (Pro12Ala, C1431T, and C-681G) with asthma ...
Palmer, C. N. A., Doney, A. S. F., Ismail, T., Lee, S. P., Murrie, I., Macgregor, D. F., Mukhopadhyay, S.   +6 more
openaire   +3 more sources