Results 271 to 280 of about 38,455 (298)

PPARG-mediated ferroptosis in dendritic cells limits antitumor immunity

Biochemical and Biophysical Research Communications, 2021
Dendritic cells (DCs) are antigen-presenting cells of the immune system, which play a key role in antitumor immunity by activating cytotoxic T cells. Here, we report that elevated ferroptosis, a lipid peroxidation-mediated cell death, impairs the maturation of DCs and their function in tumor suppression. Ferroptosis is selectively induced in DCs by the
Leng Han, Lulu Bai, Chunjing Qu, Enyong Dai, Jiao Liu, Rui Kang, Di Zhou, Daolin Tang, Yanan Zhao   +8 more
openaire   +2 more sources

Activation of PPARG inhibits dominant follicle development in cattle

Theriogenology, 2020
The peroxisome proliferator-activated receptor gamma (PPARG, also called NR1C3) is a nuclear receptor of the peroxisome proliferator-activated receptor family (PPAR). PPARs are involved in the regulation of apoptosis, cell cycle, estradiol and progesterone synthesis, and metabolism.
Juliana G, Ferst, Monique T, Rovani, Andressa M P, Dau, Bernardo G, Gasperin, Alfredo Q, Antoniazzi, Vilceu, Bordignon, Dimas E, Oliveira, Paulo B D, Gonçalves, Rogério, Ferreira   +8 more
openaire   +2 more sources

PPARG-Activated Bladder Cancer Cells Exhibit a PPARG Dependency

Cancer Discovery, 2017
Abstract PPARG-selective inverse agonists can suppress proliferation in PPARG-activated bladder cancer cells.
openaire   +1 more source

Functionally conserved PPARG exonic circRNAs enhance intramuscular fat deposition by regulating PPARG and HSL

International Journal of Biological Macromolecules
Circular RNAs (circRNA) are a kind of endogenous biological macromolecules that play significant roles in many biological processes, including adipogenesis, a precisely orchestrated process that is mediated by a large number of factors. Among them, peroxisome proliferator-activated receptor gamma (PPARG), is undoubtedly the most important regulator of ...
Ruirui, Zhu, Ye, Feng, Xintong, Yang, Ruirui, Li, Ziyi, Song, Qingyou, Liu, Deshun, Shi, Jieping, Huang   +7 more
openaire   +2 more sources

Spindle Cell/Sclerosing Rhabdomyosarcoma With PAX8::PPARG Fusion

International Journal of Surgical Pathology, 2022
The spindle cell/sclerosing subtype of rhabdomyosarcoma is classified based on genetic features into the three categories of MYOD1-mutated, gene fusion-driven, and a subset without a currently identified genetic driver event. The gene fusion-driven spindle cell/sclerosing rhabdomyosarcomas are heterogenous and characterized by increasing numbers of ...
Dinesh Rakheja, Jason Y. Park, Mustafa Alhasan, Naseem Uddin   +3 more
openaire   +2 more sources

[PPARG gene polymorphism and disease susceptibility].

Nihon rinsho. Japanese journal of clinical medicine, 2010
PPARgamma plays a key role in the regulation of adipocyte differentiation and energy balance. The polymorphism in human PPARG gene resulting in the substitution of Pro12 to Ala in the PPARgamma2 isoform has been established as conferring anti-diabetic and anti-obesity effects, especially in the conditions such as westernized lifestyle with high levels ...
openaire   +1 more source

EFFECT OF PPARG INHIBITION ON HUMAN BMSC CELL FATE

Orthopaedic Proceedings
The effects of dexamethasone (dex), during in vitro human osteogenesis, are contrasting. Indeed, dex downregulates SOX9 during osteogenic differentiation of human bone marrow mesenchymal stromal cells (HBMSCs). However, dex also promotes PPARG expression, resulting in the formation of adipocyte-like cells within the osteogenic monolayers.
Maria Rosa Iaquinta, Carmen Lanzillotti, Mauro Tognon, Fernanda Martini, Martin J Stoddart, Elena Della Bella   +5 more
openaire   +2 more sources

TNFα Mediates Inflammation-Induced Effects on PPARG Splicing in Adipose Tissue and Mesenchymal Precursor Cells

Cells, 2022
Simona Cataldi, Marianna Aprile, Mireille Cormont   +2 more
exaly  

PPARG in osteocytes controls sclerostin expression, bone mass, marrow adiposity and mediates TZD-induced bone loss

Bone, 2021
Sudipta Baroi, Beata Lecka-Czernik, Patrick R Griffin   +2 more
exaly  

A PPARG Splice Variant in Granulosa Cells Is Associated with Polycystic Ovary Syndrome

Journal of Clinical Medicine, 2022
Chaoyi Shi, Jing-Jing Xu, Yan-Ting Wu
exaly