Results 101 to 110 of about 350,201 (281)

Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling

Advanced Science, EarlyView.
Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...
Qi Wang, Tingting Qu, Qibing Sun, Ran Li, Junfei Dong, Yuming Du, Ziyin Xuan, Lei Wang, Hanli Li, Jianyun Sun, Fangliang Chen, Jinshuai Liu, Zifan Yang, Jianxiang Lei, Qian Yang, Bin Wang, Zhiming Zhou, Yu Wang   +17 more
wiley   +1 more source

Buenas prácticas en la enseñanza del inglés como lengua extranjera: estudiantes de Práctica Profesional I - UPNFM - Honduras

Revista Digital de Políticas Lingüísticas, 2021
La práctica profesional es un espacio formativo en la que los futuros docentes del sistema educativo hondureño muestran las competencias adquiridas durante los años de formación teórica en las aulas de la Universidad Pedagógica Nacional Francisco Morazán
Clara Elizabeth Chávez Suazo
doaj  

NUP85 Mediates Endoplasmic Reticulum Stress through the USP47/ASK1 Signaling Pathway to Regulate the Progression of Liver Fibrosis

Advanced Science, EarlyView.
In the present study, we have demonstrated that the NUP85‐USP47‐ASK1 signaling pathway may have regulated the progression of liver fibrosis through modulating ERS. Additionally, we have developed a CREKA‐coupled liposome to target delivery of MV, a pharmacological inhibitor of NUP85, to activated HSCs, thereby attenuating liver fibrosis. ABSTRACT Liver
Dashuai Yang, Haoran Yang, Linxin Pan, Chang Tian, Fucheng Zuo, Shilei Huang, Xianrui Li, Ming Chen, Cheng Qian, Jie Wang, Zhaolin Chen, Tao Xu   +11 more
wiley   +1 more source

In silico prediction of differentially expressed genes and functionally grouped networks in patients with inflamed pulp for screening pulpitis biomarkers

European Oral Research
Purpose: Pulpitis is one of the most common oral inflammatory diseases. There are many limitations in the traditional methods of diagnosing pulpitis. By replacing new diagnostic ways based on biomarkers, it is possible to quickly and accurately identify ...
Azizeh Asadzadeh, Fatemeh Shams Moattar, Azam Moshfegh   +2 more
doaj   +1 more source

Randomised controlled trial of silk therapeutic garments for the management of atopic eczema in children: the CLOTHES trial

Health Technology Assessment, 2017
Background: Atopic eczema (AE) is a chronic, itchy, inflammatory skin condition that affects the quality of life of children and their families. The role of specialist clothing in the management of AE is poorly understood.
Kim S Thomas, Lucy E Bradshaw, Tracey H Sach, Fiona Cowdell, Jonathan M Batchelor, Sandra Lawton, Eleanor F Harrison, Rachel H Haines, Amina Ahmed, Taraneh Dean, Nigel P Burrows, Ian Pollock, Hannah K Buckley, Hywel C Williams, Joanne Llewellyn, Clare Crang, Jane D Grundy, Juliet Guiness, Andrew Gribbin, Eileen V Wake, Eleanor J Mitchell, Sara J Brown, Alan A Montgomery   +22 more
doaj   +1 more source

Inflation targeting: what inflation rate to target? [PDF]

In an economy with nominal rigidities in both an intermediate good sector and a finished good sector, and thus with a natural distinction between CPI and PPI inflation rates, a benevolent central bank faces a tradeoff between stabilizing the two measures
Kevin X. D. Huang, Zheng Liu
core  

N4‐acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

Advanced Science, EarlyView.
This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley   +1 more source

TAVI Through the Years: A Systematic Review of Progress

Journal of Pharmacy and Bioallied Sciences
Introduction: Transcatheter Aortic Valve Implantation (TAVI) has evolved over the years and now is being used in the management of patients with symptomatic severe aortic stenosis (AS) in categories of high, intermediate, and even low operative risk ...
Sahil Ahmad, Mukhyaprana M. Prabhu, Rama Bhat, Asif Hasan, Amber Ahmad, Rida Ahmad   +5 more
doaj   +1 more source

Measuring quality in community nursing: a mixed-methods study

Health Services and Delivery Research, 2018
Background: High-quality nursing care is crucial for patients with complex conditions and comorbidities living at home, but such care is largely invisible to health planners and managers. Nursing care quality in acute settings is typically measured using
Sue Horrocks, Katherine Pollard, Lorna Duncan, Christina Petsoulas, Emma Gibbard, Jane Cook, Ruth McDonald, Lesley Wye, Pauline Allen, Pete Husband, Lizanne Harland, Ailsa Cameron, Chris Salisbury   +12 more
doaj   +1 more source

PPI partnerships versus PPI divorces in developing countries (or are we switching from PPPI to PPDI?) [PDF]

Thirty years ago, in 1974, Chile launched the first large-scale privatization in a developing country. About 15 years later, Argentina provided a new model of global infrastructure management.
Estache, Antonio
core