Results 131 to 140 of about 280,167 (308)

TRIM28‐Derived Peptide Exerts Anti‐Tumor Roles by Stabilizing Tumor Suppressive BRD7 Protein in Multiple Cancers

open access: yesAdvanced Science, EarlyView.
An α‐helical peptide, TAB12, designed to mimic the TRIM28 binding interface, competitively disrupts the TRIM28‐BRD7 interaction, thereby blocking ubiquitin‐mediated degradation of the tumor suppressor BRD7. This stabilization unleashes potent anti‐tumor effects across multiple tumor types with a favorable safety profile, offering a feasible strategy ...
Qingqing Wei   +10 more
wiley   +1 more source

Perspective of Teacher in Dumai-Riau Indonesia Suitability National Examination as A Picture Quality Student [PDF]

open access: yes, 2015
The national test is one method that is chosen by the Indonesian government to determine the stage and picture quality of education in Indonesia. However, in reality the national exam is also used as a measure for the condition continue to the next level
Rozamuri, Arif Murti; Universiti Kebangsaan Malaysia Bangi, Selangor.   +1 more
core  

Nanoparticle‐Mediated TIPE1 mRNA Delivery Enhances Paclitaxel Sensitivity in Triple‐Negative Breast Cancer by Modulating RAB7A Ubiquitination‐Associated Stability and Autophagy

open access: yesAdvanced Science, EarlyView.
TIPE1m NPs nanoparticles restore TIPE1 expression, promote RAB7A ubiquitination and degradation, suppress autophagic flux, and resensitize paclitaxel‐resistant triple‐negative breast cancer to therapy. ABSTRACT Acquired paclitaxel (PTX) resistance remains a major obstacle in triple‐negative breast cancer (TNBC) treatment.
Wei Hu   +9 more
wiley   +1 more source

Treatment Options in Eosinophilic Oesophagitis

open access: yesEuropean Medical Journal Allergy & Immunology, 2016
Eosinophilic oesophagitis (EoE) is an increasingly prevalent chronic inflammatory disorder diagnosed by the presence of oesophageal symptoms and eosinophilic inflammation on endoscopic histology.
Anna M. Lipowska   +2 more
doaj  

Integration of DC Households System Generated by Single-Phase Rooftop PVs into Unbalanced Three-Phase Residential Feeder [PDF]

open access: yes, 2018
This paper mitigates the integration of DC households that generated by single-phase photovoltaic (PV) into the unbalanced three-phase residential feeder.
Yusman, Yusman; Department of Electrical Engineering, Politeknik Negeri Lhokseumawe   +4 more
core  

Copper‐Doped Prussian Blue Nanozymes With Hyaluronic Acid‐Mediated Targeting Alleviate Oxidative Stress and Regulate Cholesterol Handling for Atherosclerosis Therapy

open access: yesAdvanced Science, EarlyView.
CuPB@HA is a CD44‐associated, plaque‐targeted nanozyme that alleviates oxidative stress, inflammation, and lipid accumulation in macrophages. By reducing CD36‐dependent lipid uptake and promoting ABCA1/ABCG1‐mediated cholesterol handling, it improves macrophage function, preferentially accumulates in atherosclerotic lesions, reduces plaque burden, and ...
Jianliang Ou   +14 more
wiley   +1 more source

The Study of Economic and Social Karst Region East Kutai Regency [PDF]

open access: yes, 2015
Karst Mountains is a landscape of limestone mountains are concatenated to form a corridor-biodiversity, ecosystem where the lives of millions of species of flora and fauna supporting life balance.
Irwan, Irwan; Faculty of Forestry, Mulawarman University, Samarinda 75516 East Kalimantan   +1 more
core  

Targeting Hippocampal PTEN Suppresses Ferroptosis and Rescues Cognitive Decline in Alzheimer's Disease via Dual AKT/GSK3β/Nrf2 and AKT/STAT3 Axes

open access: yesAdvanced Science, EarlyView.
PTEN knockdown activates AKT phosphorylation, promoting Nrf2 nuclear translocation and STAT3 activation, which upregulates GPX4 and antioxidant enzymes HO‐1, SOD1, SOD2, and NQO1. These coordinated changes reduce lipid peroxidation and ROS, inhibit ferroptosis, and ultimately ameliorate cognitive impairment in APP/PS1 transgenic mice, highlighting a ...
Da‐Wei Wang   +5 more
wiley   +1 more source

PPI-model

open access: yes
Code to run simulations from the publication 'A computational framework for the investigation of phosphoinositide regulation'.
openaire   +1 more source

Bayesian Model Averaging. An Application to Forecast Inflation in Colombia [PDF]

open access: yes
An application of Bayesian Model Averaging, BMA, is implemented to construct combined forecasts for the colombian inflation for the short and medium run. A model selection algorithm is applied over a set of linear models with a large dataset of potencial
Eliana González
core  

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