Results 181 to 190 of about 280,167 (308)

FTSJ3‐Mediated 2′‐O‐Methylation of HSPA5 mRNA Stabilizes BOP1 via SUMOylation to Drive DRP1‐Dependent Mitochondrial Fission and Fatty Acid Oxidation in Lung Squamous Cell Carcinoma

Advanced Science, EarlyView.
The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu, Jiaheng Lin, Yifei Zhu, Ying Liu, Guoren Zhou   +4 more
wiley   +1 more source

Benefits and challenges of a Patient & Public Involvement (PPI) peer researcher. [PDF]

Res Involv Engagem
Westwood N, Tanner J, Brierley-Jones L, Cheng A, Rochon M, Vaja R, Dearling J, Wilson K, Murphy GJ, Rogers LJ.   +9 more
europepmc   +1 more source

TNAP and PHOSPHO1 Function Synergistically to Afford Critical Control Over the Mineralization of the Postnatal Murine Skeleton

Advanced Science, EarlyView.
Biomineralization underpins skeletal development, yet its molecular control remains incompletely understood. Using a novel murine knockout model, this study reveals the essential and complementary roles of PHOSPHO1 and TNAP in postnatal skeletal development.
Lucie E. Bourne, Aikta Sharma, Scott Dillon, Jacob Keen, Soher N. Jayash, Natalie Crump, Lucinda A.E. Evans, Maya Karmali, Worachet Promruk, Claire E. Clarkin, Sonoko Narisawa, Louise Stephen, Brian L. Foster, José Luis Millán, Colin Farquharson, Katherine A. Staines   +15 more
wiley   +1 more source

Public and Patient Involvement in Research in the Fields of Inflammatory or Autoimmune Ocular Diseases: Protocol for a Scoping Review. [PDF]

JMIR Res Protoc
Tynan G, Collins D, Sheehy E, Lauder M, Dunne N, Greenan E, Walsh K, Doyle A, Ní Gabhann-Dromgoole J.   +8 more
europepmc   +1 more source

Eco‐Friendly Laser‐Induced Graphene/Perovskite Hybrids for Eco‐Friendly Photodetectors

Advanced Electronic Materials, EarlyView.
A sustainable paper‐based photodetector was developed by combining laser‐induced graphene (LIG) with MAPbI3 perovskite. Compared with pure LIG devices, the hybrid photodetector exhibited nearly 10‐fold higher responsivity and 7‐fold greater detectivity while maintaining stable performance after 1000 bending cycles, demonstrating its potential for ...
Ya‐Yun Huang, Wei‐Hua Hsu, Bo‐Hua Chiou, Wei‐Chen Tu   +3 more
wiley   +1 more source

Fabrication of soy protein - pea protein composite fibril/κ-carrageenan emulsion gels through thermal fibrillation for application as fat replacers in ice cream. [PDF]

Curr Res Food Sci
Li Y, Zuo Z, Chen Y, Yang X, Gong Y, Wang T, Chu L, Wang H.   +7 more
europepmc   +1 more source

Modulation of Local Environment for Selective Bicarbonate Conversion to Multi‐Carbon Products

Advanced Energy Materials, EarlyView.
Highly porous Cu electrode partially coated with an ionomer/carbon composite enables efficient conversion of bicarbonate to multi‐carbon products. By regulating the local reaction microenvironment, this strategy overcomes selectivity and reaction‐rate limitations, achieving Faradaic efficiencies of 43% for ethylene and 60% for total multi‐carbon ...
Tai Nguyen, Anh N. Nguyen, Guorui Gao, Jackson Crane, Thành Trần‐Phú, Gelson Tavares da Silva, Aldo Gonzalez‐Lopez, Hung Lai, Khac Huy Dinh, Duc‐Minh Phan‐Pham, Martin Guay, Carlos Escobedo, Rosalie K. Hocking, Jonathan Raisin, Lucia H. Mascaro, Cao‐Thang Dinh   +15 more
wiley   +1 more source

Pantoprazole and other proton pump inhibitors, sleep, and cardiovascular safety: weak but plausible evidence. [PDF]

Rev Assoc Med Bras (1992)
Menezes-Rodrigues FS, Tallo FS, Herbella FAM, Caixeta A, Tonan RR, Bittencourt LRA, Tufik S, Andersen ML, Gehrke FS.   +8 more
europepmc   +1 more source

AI‐Driven Cancer Multi‐Omics: A Review From the Data Pipeline Perspective

Advanced Intelligent Discovery, EarlyView.
The exponential growth of cancer multi‐omics data brings opportunities and challenges for precision oncology. This review systematically examines AI's role in addressing these challenges, covering generative models, integration architectures, Explainable AI for clinical trust, clinical applications, and key directions for clinical translation.
Shilong Liu, Shunxiang Li, Kun Qian
wiley   +1 more source

Enhancing the Prospective Acceptability of a Paediatric Speech and Language Therapy Intervention With Parents From Under-Represented Communities. [PDF]

Health Expect
Rodgers L, Botting N, Herman R.
europepmc   +1 more source