Results 21 to 30 of about 36,916 (167)

PPIs therapy has a negative impact on the clinical outcomes of advanced SCLC patients treated with PD-L1 inhibitors

BMC Pulmonary Medicine, 2023
Background Programmed death-ligand 1 (PD-L1) inhibitors has emerged as a first-line therapeutic strategy for advanced small cell lung cancer (SCLC), which can stimulate T-cell activation, thereby preventing tumor avoidance of immunologic surveillance ...
Sisi Zhang, Jing Tian, Xinwei Wang, Chengxin Liu   +3 more
doaj   +1 more source

Effect of proton pump inhibitors on in vitro activity of tigecycline against several common clinical pathogens. [PDF]

PLoS ONE, 2014
In this study, we evaluated the effect of proton pump inhibitors (PPIs) on in vitro antimicrobial activity of tigecycline against several species of clinical pathogens.
Wentao Ni, Xuejiu Cai, Beibei Liang, Yun Cai, Junchang Cui, Rui Wang   +5 more
doaj   +1 more source

The Effect of Proton Pump Inhibitors on Metastatic Breast Cancer in Patients Treated with CDK4/6i [PDF]

Middle East Journal of Cancer
Background: This study aimed to assess the effect of proton pump inhibitors (PPIs) on hormone receptor-positive (HR+) and her-2-negative (her2-) metastatic breast cancer (MBC) in patients receiving CDK4/6i.Method: In a retrospective study, patients were ...
Mohamed Khalifa, Amrallah Mohammed, Yara Mohamed, Isra Mahgoub, Mohamed Awadallah, Basant Elshafaay, Amira Hanna, Ahmed Obaya, Yaser Arafat   +8 more
doaj   +1 more source

Utilization of macrocyclic peptides to target protein-protein interactions in cancer

Frontiers in Oncology, 2022
Protein-protein interactions (PPIs) play vital roles in normal cellular processes. Dysregulated PPIs are involved in the process of various diseases, including cancer.
Jiawen Yang, Jiawen Yang, Jiawen Yang, Qiaoliang Zhu, Yifan Wu, Yifan Wu, Yifan Wu, Xiaojuan Qu, Xiaojuan Qu, Xiaojuan Qu, Haixia Liu, Haixia Liu, Haixia Liu, Biao Jiang, Biao Jiang, Di Ge, Xiaoling Song   +16 more
doaj   +1 more source

MEDICI: Mining Essentiality Data to Identify Critical Interactions for Cancer Drug Target Discovery and Development. [PDF]

PLoS ONE, 2017
Protein-protein interactions (PPIs) mediate the transmission and regulation of oncogenic signals that are essential to cellular proliferation and survival, and thus represent potential targets for anti-cancer therapeutic discovery.
Sahar Harati, Lee A D Cooper, Josue D Moran, Felipe O Giuste, Yuhong Du, Andrei A Ivanov, Margaret A Johns, Fadlo R Khuri, Haian Fu, Carlos S Moreno   +9 more
doaj   +1 more source

A generalized approach to predicting protein-protein interactions between virus and host

BMC Genomics, 2018
Background Viral infection involves a large number of protein-protein interactions (PPIs) between virus and its host. These interactions range from the initial binding of viral coat proteins to host membrane receptor to the hijacking the host ...
Xiang Zhou, Byungkyu Park, Daesik Choi, Kyungsook Han   +3 more
doaj   +1 more source

Omeprazole was safely reused in a rhabdomyolysis patient associated with proton pump inhibitors: A case report

Clinical Case Reports, 2023
Key Clinical Message Proton pump inhibitors (PPIs) are commonly used in the clinical treatment of abnormal gastric acid secretion and gastric acid related diseases.
Zhen Wang, Jun Shen, Lei Zhang
doaj   +1 more source

Formulation of Dosage Forms with Proton Pump Inhibitors: State of the Art, Challenges and Future Perspectives

Pharmaceutics, 2022
Since their introduction to pharmacotherapy, proton pump inhibitors (PPIs) have been widely used in the treatment of numerous diseases manifested by excessive secretion of gastric acid.
Justyna Srebro, Witold Brniak, Aleksander Mendyk   +2 more
doaj   +1 more source

Improved homology-driven computational validation of protein-protein interactions motivated by the evolutionary gene duplication and divergence hypothesis

BMC Bioinformatics, 2009
Background Protein-protein interaction (PPI) data sets generated by high-throughput experiments are contaminated by large numbers of erroneous PPIs. Therefore, computational methods for PPI validation are necessary to improve the quality of such data ...
Bauer Johann W, Hintner Helmut, Kern Thomas, Dorfer Viktoria, Kommenda Michael, Frech Christian, Önder Kamil   +6 more
doaj   +1 more source

Gender differences in prepulse inhibition (PPI) in bipolar disorder: men have reduced PPI, women have increased PPI [PDF]

The International Journal of Neuropsychopharmacology, 2009
Prepulse inhibition (PPI) is a measure of sensorimotor gating or information processing. Few studies have examined PPI in bipolar disorder (BD); two studies reported a PPI disruption and two reported no change. There are gender differences in PPI and within the clinical profile of BD, which may explain some of these discrepancies.
Gogos, Andrea, van den Buuse, Maarten, Rossell, Susan   +2 more
openaire   +3 more sources