Results 121 to 130 of about 217,698 (299)

Prediction of Acute Liver Injury Trajectory in Patients Following Acetaminophen Overdose: A Multibiomarker Machine Learning Proof‐of‐Concept Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical translation of novel therapies can be hindered by heterogeneity‐driven sample size inflation in late‐stage trials. In acetaminophen‐induced liver injury (APAP DILI), many patients recover spontaneously, diluting investigational drug efficacy signals.
Chris Humphries, Alastair M. Kilpatrick, Kathleen M. Scullion, Rhona Aird, Lorraine Bruce, Maria Elena Candela, Tak Yung Man, Stuart J. Forbes, James W. Dear   +8 more
wiley   +1 more source

Bayesian phylogenetic and recombination analyses of plum pox virus provide a refined vision of its evolutionary history

Virology Journal
Background The discovery of a plum tree isolate of plum pox virus (PPV, Potyvirus plumpoxi), done in Eastern Albania in 2011 in the frame of an EU-funded survey, which represents a divergent strain named PPV-An, proved to be original and informative for ...
F. Palmisano, S. Kawakubo, M. Chiumenti, P. Leonetti, V. Pantaleo, T. Candresse, A. Minafra   +6 more
doaj   +1 more source

Public Sustainability: Thematic Mapping, Theoretical Approaches and Emerging Lines of Action

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT The paucity of research analysing thematic persistence in public sustainability limits our understanding of how this field of research evolves and reconfigures itself. The present paper addresses this gap through a longitudinal bibliometric analysis of 692 publications processed with SciMAT. The methodology combines co‐word analysis, strategic
Laila Ribii Khalifi, Luisa‐Eugenia Reyes, Marisol Carvajal Camperos   +2 more
wiley   +1 more source

Optimization of cut‐hole layout under high in situ stress based on numerical simulation and field tests

Deep Underground Science and Engineering, EarlyView.
This study investigates the blast‐induced rock damage patterns under different cut‐hole layouts and ground stress conditions through numerical simulations and field tests. The findings in this study provide valuable insights for similar underground engineering applications.
Junjie Zhao, Diyuan Li, P. G. Ranjith, Xinxin Lü, Yanliang Li, Xiaoli Su   +5 more
wiley   +1 more source

Exploring wave propagation behaviors in rock: A grain‐based perspective on mineral structures

Deep Underground Science and Engineering, EarlyView.
This study investigates wave propagation in rock at the grain scale using a grain‐based model, revealing that mineral elastic modulus significantly influences wave attenuation while grain size and distribution have limited effects. A novel peak particle velocity attenuation prediction model is proposed and validated for grain‐scale wave propagation ...
Zhiyi Liao, Jiachen Xu, Kai Zhang, Changtai Zhou   +3 more
wiley   +1 more source

Instability mechanism and failure characteristics of underground cavern in block system under the action of seismic waves

Deep Underground Science and Engineering, EarlyView.
Seismic waves with tensile stress, high amplitude, and low frequency are most likely to trigger block instability and sliding. Blocks with a single sliding surface are more prone to movement than those with multiple constraints, and roof‐positioned blocks are especially vulnerable to slide.
Xiao Wang, Jinxiao Liu, Gaoshuo Zhang, Wenxin Li, Changdi He   +4 more
wiley   +1 more source

Porcine parvovirus infection induces necroptosis of porcine placental trophoblast cells via a ZBP1-mediated pathway

Veterinary Research
Porcine parvovirus (PPV) infection induces germ cell death, leading to reproductive disorders in first-pregnant sows. Porcine placental trophoblast cells (PTCs) are the major target of PPV, and we have previously found that PPV infection leads to the ...
Ning Xu, Qian Du, Yijiao Cheng, Lichen Nie, Peipei Ma, Dingwen Feng, Yong Huang, Dewen Tong   +7 more
doaj   +1 more source

Machine learning‐based prediction of elevated N terminal pro brain natriuretic peptide among US general population

ESC Heart Failure, Volume 12, Issue 2, Page 859-868, April 2025.
Abstract Aims Natriuretic peptide‐based pre‐heart failure screening has been proposed in recent guidelines. However, an effective strategy to identify screening targets from the general population, more than half of which are at risk for heart failure or pre‐heart failure, has not been well established.
Yuichiro Mori, Shingo Fukuma, Kyohei Yamaji, Atsushi Mizuno, Naoki Kondo, Kosuke Inoue   +5 more
wiley   +1 more source

Left ventricular function improvement during angiotensin receptor–neprilysin inhibitor treatment in a cohort of HFrEF/HFmrEF patients

ESC Heart Failure, Volume 12, Issue 2, Page 1151-1165, April 2025.
Prediction of LVEF improvement in patients with HFrEF and HFmrEF following treatment with Sacubitril/Valsartan. Workflow of this study investigating the functional capacity improvement in response to Sacubitrail/Valsartsan in a real‐world scenario of heart failure treatment.
Florian Appenzeller, Tobias Harm, Manuel Sigle, Parwez Aidery, Klaus‐Peter Kreisselmeier, Livia Baas, Andreas Goldschmied, Meinrad Paul Gawaz, Karin Anne Lydia Müller   +8 more
wiley   +1 more source

Bilateral ictal eye closure in focal epileptic seizures: SEEG retrospective observational assessment from a tertiary epilepsy center

Epileptic Disorders, EarlyView.
Abstract Ictal eye closure is commonly associated with functional seizures but may also occur in epileptic seizures. We retrospectively reviewed 113 consecutive stereo‐EEG (SEEG) recordings from adults with drug‐resistant focal epilepsy (2015–2024) to identify prolonged bilateral eye closure during seizures.
Paola Vassallo, Christina Pourlou, Joana F. A. Oliveira, Davide Giampiccolo, Charlotte McLaughlin, Emma Torzillo, Umair Javaid Chaudhary, John S. Duncan, Josemir W. Sander, Fahmida Chowdhury, Beate Diehl   +10 more
wiley   +1 more source