Results 101 to 110 of about 74,936 (290)

On Collaborative Predictive Blacklisting

, 2018
Collaborative predictive blacklisting (CPB) allows to forecast future attack sources based on logs and alerts contributed by multiple organizations. Unfortunately, however, research on CPB has only focused on increasing the number of predicted attacks ...
De Cristofaro, Emiliano, Melis, Luca, Pyrgelis, Apostolos   +2 more
core  

Optimizing Diagnostic Accuracy of Clinical Red Flags in RASopathies

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT RASopathies are a group of genetic disorders caused by pathogenic variants in the RAS‐mitogen‐activated protein kinase (RAS–MAPK) signaling pathway, often presenting with congenital heart defects, craniofacial dysmorphisms, and developmental delays. To assess the diagnostic yield of genetic testing in patients with suspected RASopathies and to
Emanuele Bobbio, Martina Caiazza, Emanuele Monda, Giustina Aruta, Alberto Budillon, Augusto Esposito, Adelaide Fusco, Annapaola Cirillo, Marta Rubino, Immacolata Viscovo, Gioacchino Scarano, Matteo Della Monica, Vincenzo Nigro, Giulio Piluso, Leandro Pecchia, Maria Giovanna Russo, Giuseppe Limongelli   +16 more
wiley   +1 more source

Atypical Clinical Course of Griscelli Syndrome Type 2 With Primarily Neurologic Presentation and Adult‐Onset in a 46‐Year‐Old Male

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Griscelli Syndrome Type 2 (GS2) is a rare autosomal recessive disorder caused by pathogenic mutations in the RAB27A gene. Typically, it is characterized by cutaneous hypopigmentation, immunodeficiency, with or without neurological abnormalities secondary to hemophagocytic lymphohistiocytosis (HLH). Without treatment, GS2 often results in fatal
Dzhoy Papingi, Michael Kutsche, Helena Lichtenfeld, Fanny Kortüm, Angela Abicht, Laura Herrmann, Theresia Herget   +6 more
wiley   +1 more source

Circulating TREM2 as a noninvasive diagnostic biomarker for NASH in patients with elevated liver stiffness

Hepatology, EarlyView., 2022
Abstract Background and Aims Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH. This study investigates the diagnostic accuracy of the circulating triggering receptor expressed on myeloid cells 2 (plasma TREM2) as a biomarker for NASH in patients with NAFLD and elevated liver stiffness.
Vineesh Indira Chandran, Charlotte Wilhelmina Wernberg, Mette Munk Lauridsen, Maria Kløjgaard Skytthe, Sofie Marchsteiner Bendixen, Frederik Tibert Larsen, Camilla Dalby Hansen, Lea Ladegaard Grønkjær, Majken Storm Siersbæk, Tina Di Caterino, Sönke Detlefsen, Holger Jon Møller, Lars Grøntved, Kim Ravnskjaer, Søren Kragh Moestrup, Maja Sofie Thiele, Aleksander Krag, Jonas Heilskov Graversen   +17 more
wiley   +1 more source

Temporal Modeling of Amyloid and Tau Trajectories in Alzheimer's Disease Using PET and Plasma Biomarkers

Annals of Neurology, EarlyView.
Objective This study aimed to compare positron emission tomography (PET) and plasma‐based temporal modeling of amyloid and tau biomarkers in Alzheimer's disease. Methods Longitudinal amyloid PET (n = 1,097, mean age ± SD = 72.5 ± 7.38 year, 51.4% male), 18F‐flortaucipir tau‐PET (n = 230, 74.3 ± 7.18 year, 52.2% female), and Fujirebio Lumipulse plasma p‐
Christopher A. Brown, Katheryn A.Q. Cousins, Magdalena Korecka, Emily McGrew, Alice Chen‐Plotkin, John A. Detre, Corey T. McMillan, Edward B. Lee, Sandhitsu R. Das, Dawn Mechanic‐Hamilton, Paul A. Yushkevich, Ilya M. Nasrallah, Leslie M. Shaw, for the Alzheimer's Disease Neuroimaging Initiative, David A. Wolk   +14 more
wiley   +1 more source

AI‐Driven Mapping of Seizure Spread Patterns

Annals of Neurology, EarlyView.
Objective The focus of epilepsy research has largely been on seizure onset; however, physicians typically examine the patterns of seizure spread past seizure onset as well. This study aims to align automated seizure analysis with clinical practice, leverage deep learning to standardize seizure annotations that varies among physicians, and understand ...
Andrew Y. Revell, Marc Jaskir, Akash R. Pattnaik, William K. S. Ojemann, Erin Conrad, Nishant Sinha, Brittany H. Scheid, Alfredo Lucas, John M. Bernabei, John Beckerle, Joel M. Stein, Sandhitsu R. Das, Brian Litt, Kathryn A. Davis   +13 more
wiley   +1 more source

Cytokeratin-18 and uric acid predicts disease severity in Taiwanese nonalcoholic steatohepatitis patients.

PLoS ONE, 2017
Background & aimsIdentification of disease severity remains a challenge in the management of non-alcoholic steatohepatitis (NASH). Cytokeratin-18 (CK18), is a recently developed non-invasive biomarker for NASH.
Jee-Fu Huang, Ming-Lun Yeh, Chung-Feng Huang, Ching-I Huang, Pei-Chien Tsai, Chi-Ming Tai, Hua-Ling Yang, Chia-Yen Dai, Meng-Hsuan Hsieh, Shinn-Chern Chen, Ming-Lung Yu, Wan-Long Chuang   +11 more
doaj   +1 more source

Assessing somatization in urologic chronic pelvic pain syndrome [PDF]

, 2019
BACKGROUND: This study examined the prevalence of somatization disorder in Urological Chronic Pelvic Pain Syndrome (UCPPS) and the utility of two self-report symptom screening tools for assessment of somatization in patients with UCPPS.
Alpers, D H, Hong, B A, Lai, H H, North, C S   +3 more
core   +1 more source

Clinical Physical Exam Shows High Sensitivity for Detecting Labral Tears in Individuals With Femoroacetabular Impingement Syndrome

Arthroscopy, EarlyView.
Purpose To determine the diagnostic performance of the combined use of radiographs and physical exam findings, compared with magnetic resonance arthrography (MRA) alone, for the primary diagnosis of labral tears in individuals with femoroacetabular impingement syndrome.
Carson Halliwell, Rebecca Moyer, George Konstantinidis, Eyal Amar, Ivan Wong   +4 more
wiley   +1 more source

ChatGPT, Claude Sonnet, and Grok Display Similarly Low Rates of Accuracy in Identifying Image‐Based Orthopaedic Sports Pathologies

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To assess the ability of artificial intelligence (AI) to identify common sports‐related pathologies using radiologic imaging and to compare ChatGPT 4.0 with 2 competitors, Grok 2 and Claude 3.5 Sonnet. Methods ChatGPT 4.0, Grok 2, and Claude 3.5 Sonnet were used. Five common orthopaedic sports pathologies were chosen: anterior cruciate ligament
Ahmad R. Alhankawi, Collin L. Braithwaite, Alejandro M. Holle, M. Lane Moore, Saad Tarabichi, Anikar Chhabra   +5 more
wiley   +1 more source