Advanced Science, EarlyView.To address the limitations of protein‐based ICIs in applications, this study constructed an engineered bacterium, HRB, capable of expressing aCD47 in hypoxic TME. Through the Schiff base reaction, responsive liposomes (LC) loaded with the STING agonist cGAMP were connected to the surface of bacteria to form HRB@LC.
Peng‐Shuo Dong +9 more
wiley +1 more source
Development and validation of a machine learning-based early warning model for carbapenem-resistant <i>Klebsiella pneumoniae</i> bloodstream infections using non-carbapenem susceptibility profiles. [PDF]
Front MicrobiolSong J +5 more
europepmc +1 more source
Knitted Pneumatic Fabrics for Dynamic Pressure Modulation in Personalized Healthcare Wearables
Advanced Science, EarlyView.A pneumatic pressure‐regulating knitted fabric (PPKF) is developed, in which knitted pneumatic circuit enables the seamless integration of ultralow radial expansion pneumatic fiber into dual‐channel textile structure. By strategically modulating channel spacing, delivering adjustable dynamic pressures and clinically relevant gradient compression ratios.
Xiaoyu Chen +5 more
wiley +1 more source
Digital Intelligence in Dental Education: A Bibliometric Analysis. [PDF]
Int Dent JGuo R, Zhang Y, Li W, Liu D, Hu W.
europepmc +1 more source
Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis
Advanced Science, EarlyView.Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason +12 more
wiley +1 more source
Interpretable multi-task prediction in rhabdomyolysis: promise and caveats. [PDF]
EClinicalMedicineXiong J, Zhao J.
europepmc +1 more source
Advanced Science, EarlyView.In a randomized clinical trial, we test the potential of combined nicotinamide (NAM) and pyridoxine (PN) to improve muscle recovery through muscle stem cell (MuSC) activity. Daily oral NAM and PN supplementation after high intensity muscle contractions enhances MuSC activation and differentiation, and accelerates muscle regeneration, providing new ...
Grith Højfeldt +14 more
wiley +1 more source
Digital Public Reporting Systems for Evaluating Health Care Quality: Systematic Review.
JMIR Med InformDu L, Suomi R, Damalie E.
europepmc +1 more source
How artificial intelligence applied to digital pathology could guide treatment personalization in breast cancer. [PDF]
ESMO Real World Data Digit OncolRuelle T +5 more
europepmc +1 more source
Advanced Science, EarlyView.This study identifies GDF15+ TAMs as a cell subset mediating tumor regression after immunotherapy. Macrophage‐intrinsic GDF15 enhances phagocytosis and antigen cross‐presentation to CD8+ T cells through the NF‐κB signaling pathway, thereby inhibiting tumor progression.
Xinyu Zhou +9 more
wiley +1 more source