Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Towards Research Excellence for Development: The Research Quality plus (RQ+) Assessment Instrument [PDF]
, 2014 This document presents a framework and practical guidelines for assessing the quality of research for development. Referred to as the "RQ+"1 assessment instrument, it serves as a tool to guide the work of external evaluators hired by IDRC as part of the ...
core
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
The Relation between Rational Perfection (Unification with Active Intellect) and Moral Perfection, in the Mulla Sadra’s View [PDF]
حکمت معاصر, 2015 The role of science and action in achieving perfection and beatitude is very notable and has very special and important place in Mulla Sadra’s view. Sadra’s phrases show that achieving rational perfection which involves unionization with active intellect
Seyyed Morteza Hoseini Shahrudi +1 more
doaj
Driver Hamiltonians for constrained optimization in quantum annealing
, 2016 One of the current major challenges surrounding the use of quantum annealers for solving practical optimization problems is their inability to encode even moderately sized problems---the main reason for this being the rigid layout of their quantum bits ...
Hen, Itay, Sarandy, Marcelo S.
core +1 more source
Healthcare students support opt-out organ donation for practical and moral reasons
, 2021 Long Qian +5 more
openalex +2 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Querying a regulatory model for compliant building design audit [PDF]
, 2015 The ingredients for an effective automated audit of a building design include a BIM model containing the design information, an electronic regulatory knowledge model, and a practical method of processing these computerised representations.
Amor, Robert +4 more
core