Results 101 to 110 of about 3,216,025 (290)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
The Form of Practical Knowledge and Implicit Cognition: A Critique of Kantian Constitutivism [PDF]
, 2016 Moral realism faces two worries: How can we have knowledge of moral norms if they are independent of us, and why should we care about them if they are independent of rational activities they govern?
Saemi, Amir
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RankPL: A Qualitative Probabilistic Programming Language
, 2017 In this paper we introduce RankPL, a modeling language that can be thought of as a qualitative variant of a probabilistic programming language with a semantics based on Spohn's ranking theory.
A Darwiche +7 more
core +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
The Dualism of the Practical Reason: Some Interpretations and Responses [PDF]
, 2008 Sidgwick’s dualism of the practical reason is the idea that since egoism and utilitarianism aim both to have rational supremacy in our practical decisions, whenever they conflict there is no stronger reason to follow the dictates of either view.
Orsi, Francesco
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
The Relation between Rational Perfection (Unification with Active Intellect) and Moral Perfection, in the Mulla Sadra’s View [PDF]
حکمت معاصر, 2015 The role of science and action in achieving perfection and beatitude is very notable and has very special and important place in Mulla Sadra’s view. Sadra’s phrases show that achieving rational perfection which involves unionization with active intellect
Seyyed Morteza Hoseini Shahrudi +1 more
doaj
Drawing Mama, a Practical Drawing Tutorial Book for Parents [PDF]
, 2019 Parents need to be closer to their children, especially when they are in early years. The process of the approach can be done in some creative way, one example is drawing together with children.
Azhar, D. A. (Devi ) +1 more
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