Results 91 to 100 of about 3,216,025 (290)

The use of electronic voting and peer assessment to encourage the development of higher order thinking skills in learners [PDF]

open access: yes, 2012
In the research reported here, electronic voting and peer assessment were used with 215 first year computer science and information technology undergraduates undertaking an electronic media design module.
Barker, Trevor, Bennett, Steve
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Natural Law: A legacy of Veritatis Splendor

open access: yesRevista Teología
The encyclical of Saint John Paul II constitutes a milestone in the history of the Church: it is the first time that the Magisterium dedicated a document to address the doctrinal foundations of moral theology.
María Soledad Paladino
doaj   +3 more sources

Mysticism and Practical Rationality Exploring Evelyn Underhill through the Lens of Phronesis

open access: yesReligions
This paper aims to justify that mysticism can be considered rational from the perspective of practical reason. Particularly, we will argue that mysticism embodies the oxymoron inherent in practical wisdom (phronesis), namely, an ordered openness.
Diego Pérez Lasserre
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

An Instrumentalist Account of How to Weigh Epistemic and Practical Reasons for Belief [PDF]

open access: yes, 2019
When one has both epistemic and practical reasons for or against some belief, how do these reasons combine into an all-things-considered reason for or against that belief?
Skipper, Mattias   +1 more
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

The Case for Growth: Why Measure Student Learning? [PDF]

open access: yes, 2015
A fundamental question -- perhaps the fundamental question -- educators ask is, "Are my students learning?" Many educators choose to gain key information from assessments that measure student achievement and growth, and for good reason: just as you might

core  

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