Results 81 to 90 of about 468,258 (305)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Trust as the End of Practical Reason. Justification Procedures
, 2012 This paper is about the epistemology of practical reason and, in particular, the function of trust as an end to be pursued rationally in praxis. Our purpose is threefold: first, to present an outline of the structure of practical reason; secondly, to ...
Giordani, Alessandro, Gomarasca, Paolo
core
Reason Maintenance - State of the Art [PDF]
, 2008 This paper describes state of the art in reason maintenance with a focus on its future usage in the KiWi project. To give a bigger picture of the field, it also mentions closely related issues such as non-monotonic logic and paraconsistency. The paper is
Bry, François, Kotowski, Jakub
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Torah and Mishpat: The Law and its Liberation Spirit [PDF]
Religious Inquiries, 2014 This essay has two primary objectives. First, acknowledging the fact that the philosopher’s fundamental responsibility, due to the conditions of social order in many regions and nations around the world, requires not merely thought but also actions that ...
Lutz Alexander Keferstein
doaj
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Professional Ethics in social sciences and practical reason [PDF]
اخلاق وحیانی, 2018 The relation between Ethics and social phenomena could be studding by investigating the roots of professional Ethics in social sciences. This article tries to define professional Ethics by focusing on it under a social theory.
Hadi Mousavi, HamidReza Hasani
doaj
Studia Universitatis Babeș-Bolyai. Philosophia, 2019 A Deleuzian incursion into Kantian Criticism. About the Doctrine of the Faculties from the Perspective of their Interest. Deleuze describes the doctrine of the faculties as a complete system of permutations.
Claudia MARTA
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source