Results 51 to 60 of about 100,694 (302)
SAGE Open, 2022 Moral reasoning is a key element of the Singapore Ministry of Education’s Character and Citizenship Education curriculum, and educators in Singapore are currently encouraged to facilitate growth in students’ moral reasoning based on the Stages of Moral ...
Lyndon Lim, Elaine Chapman
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Ethics and Practical Reasoning [PDF]
, 2017 How is practical reasoning related to ethical reasoning? The most common view is that they are identical: practical reasoning just is ethical reasoning. I criticize this view and then propose an alternative account of the relation between ethical thought
Silverstein, Matthew
core
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Teoria Jurídica Contemporânea, 2016 Resumen: El presente paper analiza la contribución de Edna Ullmann-Margalit al desarrollo del concepto filosófico de presunción (asumir desde la ocurrencia de un hecho conocido la ocurrencia de un hecho no conocido a modo de actuar sobre él).
Janaina Matida
doaj +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Should We Be Convicting People We Don't Believe to Be Guilty?
Quaestio FactiIt is doubtful that knowledge of guilt is a necessary condition for a criminal conviction. More plausibly, justified belief is required. But a criminal conviction is not grounded in belief as straightforwardly as is sometimes assumed. While epistemology
Hock Lai Ho
doaj +1 more source
Reasons: practical and adaptive
SSRN Electronic Journal, 2007 The paper argues that normative reasons are of two fundamental kinds, practical which are value related, and adaptive, which are not related to any value, but indicate how our beliefs and emotions should adjust to fit how things are in the world. The distinction is applied and defended, in part through an additional distinction between standard and non-
openaire +2 more sources