Results 71 to 80 of about 100,694 (302)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Qualitative Reasoning about Relative Directions : Computational Complexity and Practical Algorithm [PDF]

, 2013
Qualitative spatial reasoning (QSR) enables cognitive agents to reason about space using abstract symbols. Among several aspects of space (e.g., topology, direction, distance) directional information is useful for agents navigating in space.
Lee, Jae Hee
core  

PRACTICAL KNOWLEDGE AS KNOWLEDGE OF A NORMATIVE JUDGMENT

Manuscrito, 2018
According to one interpretation of Aristotle’s famous thesis, to say that action is the conclusion of practical reasoning is to say that an action is a judgment about what to do.
ERIC MARCUS
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Practice Rational Care Model: It’s Effect on Students’ Clinical Reasoning and Practical Skills at Maternity Nursing Department [PDF]

Egyptian Journal of Health Care
Clinical reasoning is the dominant of clinical practice, strengthening nursing students' abilities to gather, analyze, and interpret information, leading to hypothesis generation.
Amira Morsy Yousif, Sanaa Ghareeb Ahmed
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Reasoning about Uncertain Information and Conflict Resolution through Trust Revision [PDF]

, 2013
Due to copyright restrictions, the access to the full text of this article is only available via subscription.In information driven MAS, information consumers collect information about their environment from various sources such as sensors.
Katia Sycara, Norman, Timothy J., Fokoue, A., Sycara, K., Sensoy, Murat, Pan, J. Z., Yuqing Tang, Norman, Timothy J, Sycara, Katia P, Norman, T. J., Tang, Yuqing, Nir Oren, Sycara, Katia, Pan, Jeff Z, Jeff Z. Pan, Achille Fokoue, Fokoue, Achille, Timothy J. Norman, Tang, Y., Oren, Nir, Pan, Jeff Z., Oren, N.   +21 more
core  

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Reasoning with Large A-Boxes in Fuzzy Description Logics using DL reasoners: An Experimental Evaluation

, 2008
Cimiano P, Haase P, Ji Q, et al. Reasoning with Large A-Boxes in Fuzzy Description Logics using DL reasoners: An Experimental Evaluation. In: Proceedings of the ESWC Workshop on Advancing Reasoning on the Web: Scalability and Commonsense ...
Haase, Peter, Stoilos, Giorgos, Stamou, Giorgos, Tzouvaras, Vassilis, Mailis, Teofilos, Cimiano, Philipp ; https://orcid.org/, Ji, Qiu, Tran, Duc Thanh   +7 more
core  

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source