Results 111 to 120 of about 1,939,202 (291)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

A Sufficient Condition for the Practical Stability of Riemann-Liouville Fractional Nonlinear Systems with Time Delays

Fractal and Fractional
This study addresses the practical stability analysis of Riemann-Liouville fractional-order nonlinear systems with time delays. We first establish a rigorous formulation of initial conditions that aligns with the properties of Riemann-Liouville ...
Yongchun Jiang, Hongli Yang, Ivan G. Ivanov   +2 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Practical stability of linear switched impulsive system with time delay

Electronic Journal of Differential Equations, 2014
This article concerns the study of practical stability of linear switched impulsive systems with time delay. By using Lyapunov functions and the extended Halanay inequality, we establish sufficient conditions for the practical stability and uniform ...
Shao'e Li, Weizhen Feng
doaj  

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Practical Stability of Impulsive Control Systems

Journal of Mathematical Analysis and Applications, 1994
We use the method of vector Lyapunov functions to study practical stability of control systems with impulse effects. We shall first consider a unified method of specifying admissible control sets corresponding to any desired concept of practical stability of the impulsive control system (ICS) by reducing it to the study of impulsive differential ...
openaire   +2 more sources

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein, Maximilian Mönch, Meret Herdick, Frauke Stascheit, Sarah Hoffmann, Hannah Preßler, Philipp Mergenthaler, Carla Dusemund, Paolo Doksani, Haoqi Sun, Pushpa Narayanaswami, Andreas Meisel, Lea Gerischer, Sophie Lehnerer   +13 more
wiley   +1 more source

Factors Affecting Single and Multivehicle Motorcycle Crashes: Insights from Day and Night Analysis Using XGBoost-SHAP Algorithm

Big Data and Cognitive Computing
This study aimed to identify and compare the risk factors associated with motorcycle crash severity during both daytime and nighttime, for single and multivehicle incidents in Thailand using 2021–2024 data.
Panuwat Wisutwattanasak, Chamroeun Se, Thanapong Champahom, Rattanaporn Kasemsri, Sajjakaj Jomnonkwao, Vatanavongs Ratanavaraha   +5 more
doaj   +1 more source