Results 71 to 80 of about 1,365,427 (315)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Systems for grading the quality of evidence and the strength of recommendations I: Critical appraisal of existing approaches The GRADE Working Group

BMC Health Services Research, 2004
Background A number of approaches have been used to grade levels of evidence and the strength of recommendations. The use of many different approaches detracts from one of the main reasons for having explicit approaches: to concisely characterise and ...
Schünemann Holger, Phillips Bob, Oxman Andrew D, O'Connell Dianne, Liberati Alessandro, Hill Suzanne, Henry David, Guyatt Gordon H, Flottorp Signe, Eccles Martin, Atkins David, Edejer Tessa, Vist Gunn E, Williams John W   +13 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

'How to know what you need to do': a cross-country comparison of maternal health guidelines in Burkina Faso, Ghana and Tanzania. [PDF]

, 2012
BACKGROUND: Initiatives to raise the quality of care provided to mothers need to be given priority in Sub Saharan Africa (SSA). The promotion of clinical practice guidelines (CPGs) is a common strategy, but their implementation is often challenging ...
Williams, J., Gustafsson, Lars L, Tomson, G., Mpembeni, Rose, Eriksen, Jaran, Mpembeni, R., Tomson, Göran, Tomson Göran, Blank, Antje, Baker Ulrika, Kouyaté Bocar, Eriksen, J., Somé, Mathias, Eriksen Jaran, Baker, Ulrika, Gustafsson Lars L, Baker, U., Somé Mathias, Mpembeni Rose, Blank Antje, Kouyaté, B., Williams, John, Somé, M., Williams John, Massawe, Siriel, Blank, A., Massawe, S., Gustafsson, L.L., Kouyaté, Bocar, Massawe Siriel   +29 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

UK ambulance services clinical practice guidelines 2013 : pocket book

, 2013
The 2013 Clinical Practice Guidelines provide guidance for NHS paramedics; although the principles are applicable to the work of all pre-hospital clinicians.
Joint Royal Colleges Ambulance Liaison Committee,, National Health Service,, Association of Ambulance Chief Executives,, University of Warwick,   +3 more
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Operation & Maintenance Best Practice Guidelines / Version 4.0

, 2019
Operation and Maintenance (O&M) has become a standalone segment within the solar industry and it is widely acknowledged by all stakeholders that high-quality O&M services mitigate potential risks, improve the Levelised Cost of Electricity (LCOE ...
Naomi Chevillard, Ekow Monney, Christophe Campistron, Will Hitchcock, Andy Walker, Daniel Barandalla, Maria Sabella, Marie Bartle, Angus Campbell, Paolo V. Chiantore, Christof Körner, Kristina Thoring, Mohamed Harrou, Michela Demofonti, Ulrike Jahn, Meghann Kissane, Máté Heisz, Elena Bernardi, Bernhard Höfner, Wolfgang Rosenberg, Elizabeth Reid, Thorsten Nogge, Rob Andrews, Modesto Diaz, Bengt Jaeckel, Adele Ara, Steffen Heberlein, Alfredo Beggi, Viola Hoffmann, Dirk Zeyringer, Jan-Henning Assmus, ECompton Saunders, Hugo Uijlenbroek, Gilles Estivalet, Sophie Dingenen, Vassilis Papaeconomou, Marcel Lubbers, Ypatios Moysiadis, Aurélie Beauvais, Nicholas Gall, Jörn Carstensen, Adrien Van Den Abeele, Guillermo Oviedo Hernandez, Constantinos Peonides Martina Pianta, Vasco Vieira, Emiliano Pizzini, Thomas Sauer   +46 more
core  

Guidelines for clinical practice: development, dissemination and implementation

, 2004
Clinical guidelines are one of the most promising and effective advances for defining and improving the quality of care (Journal of Nursing Care Quality 11(5) (1997) 48; Medical Care 39(8 Suppl. 2) (2001) II-46). However, their development, dissemination
Miller, M, Miller, Morven, Kearney, Nora, Kearney, N   +3 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source