Results 71 to 80 of about 6,842,225 (303)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Systems for grading the quality of evidence and the strength of recommendations I: Critical appraisal of existing approaches The GRADE Working Group

BMC Health Services Research, 2004
Background A number of approaches have been used to grade levels of evidence and the strength of recommendations. The use of many different approaches detracts from one of the main reasons for having explicit approaches: to concisely characterise and ...
Schünemann Holger, Phillips Bob, Oxman Andrew D, O'Connell Dianne, Liberati Alessandro, Hill Suzanne, Henry David, Guyatt Gordon H, Flottorp Signe, Eccles Martin, Atkins David, Edejer Tessa, Vist Gunn E, Williams John W   +13 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The quality and clinical applicability of recommendations in pressure injury guidelines: A systematic review of clinical practice guidelines

, 2021
BACKGROUND: Pressure injuries are one of the most frequently occurring, yet preventable hospital-acquired adverse events. Given there are many clinical practice guidelines available on the prevention and treatment of pressure injuries, it is useful to ...
Schoonhoven, L, Eskes, Anne M, Chaboyer, W, McInnes, Elizabeth, Boorman, RJ, Gillespie, BM, Latimer, Sharon, Walker, Rachel M, Moore, Z, Walker, RM, Schoonhoven, Lisette, Boorman, Rhonda J, Li, Z, Gillespie, Brigid M, Moore, Zena, Latimer, S, McInnes, E, Li, Zhaoyu, Eskes, AM, Chaboyer, Wendy   +19 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Editor's Choice -- European Society for Vascular Surgery (ESVS) 2025 Clinical Practice Guidelines on the Management of Vascular Trauma

OBJECTIVE: The European Society for Vascular Surgery (ESVS) has developed clinical practice guidelines for the care of patients with vascular trauma with the aim of assisting physicians in selecting the optimal management strategy.METHODS: The guidelines
Dubose, Joseph J.,, Vega de Ceniga, Melina, Boyle, Jonathan R.,, Ruffino, M.A., Blair, Paul,, de Ceniga, Melina Vega,, Van Herzeele, Isabelle,, Kakkos, Stavros K, Civil, Ian D.S., Jongkind, V., Piffaretti, G., ESVS Guidelines Committee, [missing], Wahlgren, Carl Magnus,, DuBose, Joseph J, Twine, Christopher P.,, Van Herzeele, Isabelle, Boyle, Jonathan R., DuBose, J.J., Heim, C., Wahlgren, C.M., Mitchell, Erica L, Piffaretti, Gabriele,, Wanhainen, Anders,, Wipper, S., Mees, BME, Antoniou, George A., Trimarchi, Santi,, Wipper, Sabine, Dias, N.V., Engelhardt, Michael,, Coscas, Raphael,, Aylwin, C., Mitchell, E.L., Jorgensen, Joakim, Boyle, Jonathan R, Gaarder, C., Dubose, Joseph J., Civil, Ian D. S.,, Wipper, Sabine,, Kakkos, S.K., Dias, Nuno V., Civil, Ian D. S., Ruffino, Maria Antonella, Wanhainen, A., Vikatmaa, Pirkka, Mees, Barend M.E., Mees, Barend M. E.,, Aylwin, Christopher, Ruffino, Maria Antonella,, Ricco, Jean-Baptiste,, de Ceniga, Melina Vega, Kakkos, Stavros K.,, Twine, Christopher P, Mees, Barend M. E., Dias, Nuno, V, Vikatmaa, P., Antoniou, G.A., Brohi, Karim, Coscas, Raphaël, Civil, Ian D S, Davenport, Ross A, Heim, Catherine, Blair, P., Engelhardt, M., Coscas, R., Heim, Catherine,, Davidovic, Lazar B, Wanhainen, Anders, Trimarchi, Santi, Dias, Nuno, V,, Ricco, J.B., ?, ?, Mcgreevy, David T., Gaarder, Christine,, Davenport, Ross A.,, Jongkind, Vincent,, Antoniou, George A.,, Davenport, R.A., Twine, C.P., Piffaretti, Gabriele, Wahlgren, Carl Magnus, Trimarchi, S., McGreevy, David T, Blair, Paul, Antoniou, George A, Vega de Ceniga, M., Davenport, Ross A., Jorgensen, Joakim,, McGreevy, D.T., Aylwin, Christopher,, Van Herzeele, I., JørgensenIn, Joakim, Mees, Barend M E, Davidovic, Lazar B.,, Twine, Christopher P., Jongkind, Vincent, Dias, Nuno V, Ricco, Jean-Baptiste, Mitchell, Erica L.,, Brohi, K., Davidovic, Lazar B., Vikatmaa, Pirkka,, Boyle, J.R., Engelhardt, Michael, Mitchell, Erica L., Jørgensen, J., Mcgreevy, David T.,, Gaarder, Christine, Brohi, Karim,, Kakkos, Stavros K., ESVS Guidelines Committee, George A., Davidovic, L.B., Civil, IDS, Dias, Nuno, Jørgensen, Joakim   +114 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Operation & Maintenance Best Practice Guidelines / Version 4.0

, 2019
Operation and Maintenance (O&M) has become a standalone segment within the solar industry and it is widely acknowledged by all stakeholders that high-quality O&M services mitigate potential risks, improve the Levelised Cost of Electricity (LCOE ...
Naomi Chevillard, Ekow Monney, Christophe Campistron, Will Hitchcock, Andy Walker, Daniel Barandalla, Maria Sabella, Marie Bartle, Angus Campbell, Paolo V. Chiantore, Christof Körner, Kristina Thoring, Mohamed Harrou, Michela Demofonti, Ulrike Jahn, Meghann Kissane, Máté Heisz, Elena Bernardi, Bernhard Höfner, Wolfgang Rosenberg, Elizabeth Reid, Thorsten Nogge, Rob Andrews, Modesto Diaz, Bengt Jaeckel, Adele Ara, Steffen Heberlein, Alfredo Beggi, Viola Hoffmann, Dirk Zeyringer, Jan-Henning Assmus, ECompton Saunders, Hugo Uijlenbroek, Gilles Estivalet, Sophie Dingenen, Vassilis Papaeconomou, Marcel Lubbers, Ypatios Moysiadis, Aurélie Beauvais, Nicholas Gall, Jörn Carstensen, Adrien Van Den Abeele, Guillermo Oviedo Hernandez, Constantinos Peonides Martina Pianta, Vasco Vieira, Emiliano Pizzini, Thomas Sauer   +46 more
core  

European Resuscitation Council Guidelines 2025 Executive Summary

: The 2025 European Resuscitation Council (ERC) Guidelines present the most up-to-date evidence-based guidelines for the practice of resuscitation across Europe.
Spartinou, Anastasia, Monnelly, Vix, Baldi, Enrico, Semeraro, Federico, Djakow, Jana, Karageorgos, Vlasios, Lott, Carsten, Nabecker, Sabine, Ek, Jacqueline Eleonora, de Raad, Timo, Nolan, Jerry P., Olasveengen, Theresa M., Perkins, Gavin D., Rogers, Jessica, Sandroni, Claudio, Biarent, Dominique, Monsieurs, Koenraad G., Djarv, Therese, van Gils, Marlie, Yeung, Joyce, Lauridsen, Kasper G., Soar, Jasmeet, Raffay, Violetta, Smyth, Michael A., Madar, John, Schnaubelt, Sebastian, Greif, Robert, von Goor, Sander, Grasner, Jan-Thorsten, Hogeveen, Marije, Wittig, Johannes, Nikolaou, Nikolaos   +31 more
core   +2 more sources