Results 91 to 100 of about 1,365,427 (315)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Clinical Practice Guidelines

Florence Nightingale Journal of Nursing, 2019
Clinical Practice Guidelines (CPGs), have been a cornerstone of professional decision support in recent years and have come to play a pivotal role in routine clinical practice. CPGs arise from the evidence-based medicine movement, aiming at synthesizing
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doaj  

Assessing the quality of dental clinical practice guidelines [PDF]

, 2017
OBJECTIVES: The primary aim of this study was to evaluate the quality of published dental clinical guidelines using the AGREE II instrument. METHODS: Online searching of a wide range of organisations (national and International) was undertaken to ...
Patel, K, Cunningham, Ziba, Mubeen, Suhaym, Kunal Patel, Cunningham, Z, Patel, Kunal, Suhaym Mubeen, O’Rourke, Niamh, Seehra, Jadbinder; id_orcid, O'Rourke, N, Nikolaos Pandis, Cobourne, MT, Pandis, Nikolaos, Ziba Cunningham, Seehra, J, Jadbinder Seehra, Martyn. T. Cobourne, Mubeen, S, Cobourne, Martyn. T.; id_orcid, Niamh O’Rourke   +19 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Quality evaluation of preoperative assessment guidelines of elderly patients

Huli yanjiu, 2022
ObjectiveTo conduct quality evaluation and content analysis of evidence-based practice guidelines for preoperative assessment of elderly patients，and to provide theoretical basis for developing Chinese standardized content of preoperative assessment for ...
SHI Jinghua, TANG Xinyu, CAO Xiaoting, LI Yaqin   +3 more
doaj  

A case for clarity, consistency, and helpfulness : state-of-the-art clinical practice guidelines in endocrinology using the grading of recommendations, assessment, development, and evaluation system [PDF]

, 2008
CONTEXT: The Endocrine Society, and a growing number of other organizations, have adopted the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to develop clinical practice guidelines and grade the strength of ...
Vigersky, R. A., Swiglo, B. A., Murad, M. H., Brian A. Swiglo, Holger J. Schünemann, Victor M. Montori, Schünemann, H. J., Montori, V. M., Kunz, R., Regina Kunz, Robert A. Vigersky, Gordon H. Guyatt, Guyatt, G. H., M. H. Murad   +13 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Practice Guidelines, Patient Interests, and Risky Procedures

, 1996
A clinical scenario is described where an anaesthetist is concerned about the seemingly high risk/benefit ratio relating to laparoscopic versus standard inguinal hernia operations. Some options for further action by the anaesthetist are introduced.
Ross, Isobel A.
core   +1 more source

IMPLEmenting a clinical practice guideline for acute low back pain evidence-based manageMENT in general practice (IMPLEMENT) : cluster randomised controlled trial study protocol [PDF]

, 2008
Background: Evidence generated from reliable research is not frequently implemented into clinical practice. Evidence-based clinical practice guidelines are a potential vehicle to achieve this.
Denise A O'Connor, O'Connor Denise A, Mortimer, D, Grimshaw, J. M., Mortimer, D. S., Buchbinder Rachelle, Joanne E McKenzie, Duncan Mortimer, Green, Sally E., Spike Neil, Michie, S, Spike, N., Jeremy M Grimshaw, Francis, J., McKenzie, Joanne E., Buchbinder, Rachelle, French Simon D, Mortimer Duncan, McKenzie Joanne E, Simon D French, Francis, Jillian Joy, Schattner, P., Michie, S., Peter M Kent, Green, SE, Jill Francis, Neil Spike, Michie Susan, Grimshaw, JM, McKenzie, J. E., Kent, PM, French, Simon D., Spike, N, Schattner Peter, Kent, Peter M., Susan Michie, O'Connor, DA, Kent, P. M., Grimshaw Jeremy M, Spike, Neil, O'Connor, D. A., Mortimer, Duncan, Kent Peter M, O'Connor, Denise A., Rachelle Buchbinder, Peter Schattner, Michie, Susan, Francis Jill, McKenzie, JE, Schattner, P, Buchbinder, R., Grimshaw, Jeremy M., French, SD, Green Sally E, Sally E Green, Francis, J, Schattner, Peter, Green, S. E., Buchbinder, R, French, S. D.   +59 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source