Results 101 to 110 of about 1,365,427 (315)

Authorship in reports of clinical practice guidelines: A systematic cross-sectional analysis [PDF]

, 2018
Background: A transparent and explicit reporting on authors’ contributions to the development of clinical practice guidelines and on panelists’ characteristics is essential for their credibility and trustworthiness.
Semaan, Aline T., Ahmed Ali, Maya Diab, Daou, Karim N., Khamis, Assem M., Akl, Elie A., Ali, Ahmed K., Diab, Maya, Assem M. Khamis, Aline T. Semaan, Karim N. Daou, Nomier, Mohamed A., Mohamed Nomier, Elie A. Akl   +13 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Hypertension Management by Practice Guidelines

Blood Pressure, 2014
Since first published in 2003, European and other guidelines on hypertension management have ranked among the most cited papers in the medical literature (see 1).
Sverre E, Kjeldsen, Krzystof, Narkiewicz, Suzanne, Oparil, Thomas, Hedner   +3 more
openaire   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Asset Management Best Practice Guidelines / Version 1.0

, 2019
With the professionalisation and globalisation of solar investors and investment portfolios, service quality expectations rising steadily, putting increasing requirements on Asset Managers, who are expected to continuously improve the return on ...
Christophe Campistron, Maria Sabella, Angus Campbell, Aleksis Schäfer, Paolo V. Chiantore, Christof Körner, Magda Martins, Michela Demofonti, Máté Heisz Will Hitchcock, Wolfgang Rosenberg, Martina Pianta, Compton Saunders, Adele Ara, Ben Burgess, Giuseppina Casanova, Etienne Lecompte, Constantinos Peonides, Hugo Uijlenbroek, Gilles Estivalet, Vassilis Papaeconomou, David Dassler, Ypatios Moysiadis, Nicholas Gall, Pedro Rocha, Jörn Carstensen, Pierpaolo Mastromarini, Guillermo Oviedo Hernandez, Claire Schoen, Carol Cloughley, Edmee Kelsey, Thomas Sauer   +30 more
core  

Clinical practice guidelines for dementia in Australia [PDF]

, 2016
Free to read on journal website (may need to create free account first)\ud \ud Summary\ud \ud - About 9% of Australians aged 65 years and over have a diagnosis of dementia.\ud \ud - Clinical practice guidelines aim to enhance research translation by ...
Broe, Tony, Whitehead, Craig H, Yates, Mark W., Anstey, Kaarin J., Santalucia, Yvonne, Yates, Mark, Thompson, Jane, Anstey, Kaarin Jane, Pond, C. Dimity, Beattie, Elizabeth, Cumming, Robert, Dyer, Suzanne, Draper, Brian M., Kurrle, Susan, Dietz, Margaret, Laver, Kate, Draper, Brian, Crotty, Maria, Brodaty, Henry, Dyer, Suzanne M., Nay, Rhonda, Whitehead, Craig Hamilton, Koch, Susan, Cumming, Robert G, Flicker, Leon, Whitehead, Craig, Kurrle, Susan E, Clemson, Lindy, Agar, Meera Ruth, Agar, Meera R., Yates, Mark. W, Cumming, Robert G., Friel, Margaret, Kurrie, Susan, Agar, Meera, Anstey, Kaarin, Heuzenroeder, Louise Mary, Pond, C Dimity   +37 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Recommendation for the Management of Spondyloarthritis Patients in Kuwait

Open Access Rheumatology: Research and Reviews, 2020
Yaser Ali,1 Fatemah Abutiban,2 Adel Alawadhi,3 Ali AlDei,4 Ahmad Alenizi,2 Hebah Alhajeri,1 Adeeba Al-Herz,4 Waleed Alkandari,5 Ahmad Dehrab,6 Eman Hasan,3 Sawsan Hayat,1 Aqeel Ghanem,1 Khulood Saleh,5 Xenofon Baraliakos7 1Mubarak Al-Kabeer Hospital ...
Ali Y, Abutiban F, Alawadhi A, AlDei A, Alenizi A, Alhajeri H, Al-Herz A, Alkandari W, Dehrab A, Hasan E, Hayat S, Ghanem A, Saleh K, Baraliakos X   +13 more
doaj  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source