Results 81 to 90 of about 1,365,427 (315)

The Development of Clinical Practice Guidelines and Guidance Statements of the American College of Physicians: Summary of Methods

, 2010
The American College of Physicians (ACP) established its evidence-based clinical practice guidelines program in 1981. The ACP's Guidelines Committee and the staff of the Clinical Programs and Quality of Care Department develop the clinical ...
Owens, Douglas K, Qaseem, Amir, Snow, Vincenza, ,, Shekelle, Paul   +4 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The practicality of practice guidelines [PDF]

Canadian Medical Association Journal, 2011
Clinical practice guidelines are often underused in Canada because developers fail to address potential barriers to implementation during the development and dissemination of recommendations, knowledge transfer experts told delegates to the Canadian Clinical Practice Guideline Summit in Gatineau,
openaire   +1 more source

Editor's Choice -- European Society for Vascular Surgery (ESVS) 2025 Clinical Practice Guidelines on the Management of Vascular Trauma

OBJECTIVE: The European Society for Vascular Surgery (ESVS) has developed clinical practice guidelines for the care of patients with vascular trauma with the aim of assisting physicians in selecting the optimal management strategy.METHODS: The guidelines
Dubose, Joseph J.,, Vega de Ceniga, Melina, Boyle, Jonathan R.,, Ruffino, M.A., Blair, Paul,, de Ceniga, Melina Vega,, Van Herzeele, Isabelle,, Kakkos, Stavros K, Civil, Ian D.S., Jongkind, V., Piffaretti, G., ESVS Guidelines Committee, [missing], Wahlgren, Carl Magnus,, DuBose, Joseph J, Twine, Christopher P.,, Van Herzeele, Isabelle, Boyle, Jonathan R., DuBose, J.J., Heim, C., Wahlgren, C.M., Mitchell, Erica L, Piffaretti, Gabriele,, Wanhainen, Anders,, Wipper, S., Mees, BME, Antoniou, George A., Trimarchi, Santi,, Wipper, Sabine, Dias, N.V., Engelhardt, Michael,, Coscas, Raphael,, Aylwin, C., Mitchell, E.L., Jorgensen, Joakim, Boyle, Jonathan R, Gaarder, C., Dubose, Joseph J., Civil, Ian D. S.,, Wipper, Sabine,, Kakkos, S.K., Dias, Nuno V., Civil, Ian D. S., Ruffino, Maria Antonella, Wanhainen, A., Vikatmaa, Pirkka, Mees, Barend M.E., Mees, Barend M. E.,, Aylwin, Christopher, Ruffino, Maria Antonella,, Ricco, Jean-Baptiste,, de Ceniga, Melina Vega, Kakkos, Stavros K.,, Twine, Christopher P, Mees, Barend M. E., Dias, Nuno, V, Vikatmaa, P., Antoniou, G.A., Brohi, Karim, Coscas, Raphaël, Civil, Ian D S, Davenport, Ross A, Heim, Catherine, Blair, P., Engelhardt, M., Coscas, R., Heim, Catherine,, Davidovic, Lazar B, Wanhainen, Anders, Trimarchi, Santi, Dias, Nuno, V,, Ricco, J.B., ?, ?, Mcgreevy, David T., Gaarder, Christine,, Davenport, Ross A.,, Jongkind, Vincent,, Antoniou, George A.,, Davenport, R.A., Twine, C.P., Piffaretti, Gabriele, Wahlgren, Carl Magnus, Trimarchi, S., McGreevy, David T, Blair, Paul, Antoniou, George A, Vega de Ceniga, M., Davenport, Ross A., Jorgensen, Joakim,, McGreevy, D.T., Aylwin, Christopher,, Van Herzeele, I., JørgensenIn, Joakim, Mees, Barend M E, Davidovic, Lazar B.,, Twine, Christopher P., Jongkind, Vincent, Dias, Nuno V, Ricco, Jean-Baptiste, Mitchell, Erica L.,, Brohi, K., Davidovic, Lazar B., Vikatmaa, Pirkka,, Boyle, J.R., Engelhardt, Michael, Mitchell, Erica L., Jørgensen, J., Mcgreevy, David T.,, Gaarder, Christine, Brohi, Karim,, Kakkos, Stavros K., ESVS Guidelines Committee, George A., Davidovic, L.B., Civil, IDS, Dias, Nuno, Jørgensen, Joakim   +114 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Optimizing Patient Care: The Role of Designed Nursing Guidelines in Enhancing Patients’ Literacy and Outcomes Peri-Nephrolithotripsy in Ismailia City [PDF]

Egyptian Journal of Health Care
Background: Nephrolithotripsy is considered a noninvasive treatment option for patients with urolithiasis measuring less than 2 cm, to fragment stones into smaller pieces for easier elimination.
Mohamed Elbqry, Mona Mohamed Fathi Rizk, Azza Elsayed Abdelfatah Arafat, Mohamed Ashraf Abd EL-Fatah, Fatma Mohamed Elmansy   +4 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Best Practice: Draft Guidelines for Feedback: ANZSSA Guidelines for Effective Practice in Orientation and Transition

JANZSSA, 2014
DRAFT Document prepared April 2014 At the ANZSSA conference held in Wellington in December 2013, a discussion was launched with the objective of developing quality standards for Effective Practice in Orientation and Transition in postsecondary ...
Jim Elliott, Michelle Orr
doaj  

CLUSTER RANDOMIZED CONTROLLED TRIAL TO EVALUATE THE EFFECTIVENESS OF A MULTIFACETED ACTIVE STRATEGY TO IMPLEMENT LOW BACK PAIN PRACTICE GUIDELINES; EFFECT ON COMPETENCE, PROCESS OF CARE AND PATIENT OUTCOMES IN PHYSICAL THERAPY [PDF]

, 2013
The study was a cluster randomized controlled trial designed to evaluate the effectiveness of an active strategy to implement practice guidelines for low back pain in physical therapy.
Shenoy, Sonali
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source