Results 61 to 70 of about 1,113,085 (261)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Health Care Waste Management Practice in Health Care Institutions of Nepal

Journal of Nepal Health Research Council, 2017
Background: Medical waste is considered as a major public health hazard. In a developing country like Nepal, there is much concern about the management practice of medical waste.
Hari Datt Joshi, Trishna Acharya, Purushottam Dhakal, Rakesh Ayer, Khem Bahadur Karki, Meghnath Dhimal   +5 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Time to follow guidelines, protocols, and structured procedures in medical care and time to leap out

Risk Management and Healthcare Policy, 2014
Ayala Kobo-Greenhut,1–3 Amos Notea,2,3 Meir Ruach,4 Erez Onn,4 Yehunatan Hasin1 1Bar-Ilan University, Tel Aviv, Israel; 2Technion, Haifa, Israel; 3Kinneret College, Galilee, Israel; 4Baruch Padeh Medical Center, Poriya, Israel Abstract: Present ...
Kobo-Greenhut A, Notea A, Ruach M, Onn E, Hasin Y   +4 more
doaj  

Navigating fragmented care: a qualitative study on multimorbidity management challenges in Beijing’s tiered healthcare system

BMC Primary Care
Background Multimorbidity is a growing public health concern, especially in countries with aging populations. Although a tiered healthcare system has been implemented to improve primary care, managing patients with multimorbidity has been challenging ...
Conglei You, Jingyi Zhao, Tengyang Fan, Lingling Wang, Lijuan Zhang, Guohao Zhao, Huan Tang, Na Wang, Xu Yang, Mi Yao   +9 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

The Impact of Home Medication Management Practices on Medication Adherence

Behavioral Sciences
Medication adherence is a vexing challenge with nonadherence at 50% or greater among US adults. With most medications self-administered by patients in the home, home medication management practices, especially where patients store medication in the home and receptivity to guidance from healthcare providers, need to be better understood to improve ...
Lisa Gualtieri, Meredith Steinfeldt, Eden Shaveet, Brandon Estime, Meera Singhal   +4 more
openaire   +3 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Cost-effectiveness analysis of case management for optimized antithrombotic treatment in German general practices compared to usual care – results from the PICANT trial

Health Economics Review, 2019
Background By performing case management, general practitioners and health care assistants can provide additional benefits to their chronically ill patients.
Lisa R. Ulrich, Juliana J. Petersen, Karola Mergenthal, Andrea Berghold, Gudrun Pregartner, Rolf Holle, Andrea Siebenhofer   +6 more
doaj   +1 more source