Results 91 to 100 of about 6,191,678 (292)

Expert Opinion Report on the Challenges in the Management of Psoriatic Arthritis in United Arab Emirates: A Focus on Interleukin-17 Inhibitors

Open Access Rheumatology: Research and Reviews
Ahmed Abogamal,1 Humeira Badsha,2 Suad Hannawi,3 Ghita Harifi,4 Bhavna Khan,2 Atheer Al Ansari,5 Khalid A Alnaqbi,6,7 Ahmed S Zayat,8 Shady Ibrahim,9 Mohamed Taher,9 Rajaie Namas10 1Rheumatology Department, Al-Azhar University and Zahra Hospital Dubai ...
Abogamal A, Badsha H, Hannawi S, Harifi G, Khan B, Ansari AA, Alnaqbi KA, Zayat AS, Ibrahim S, Taher M, Namas R   +10 more
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Clinical analysis of the elderly patients with chronic subdural hematoma treated by trepanation and drainage under multi-disciplinary team

Chinese Journal of Contemporary Neurology and Neurosurgery, 2019
Objective To explore the multi-disciplinary diagnosis and treatment mode of elderly patients with chronic subdural hematoma (CSDH), and the effect and safety of trepanation and drainage under this mode. Methods A total of 37 elderly patients with CSDH (≥
Xue-you XU, Zhen-yu YANG, Jia-quan SONG, Jian LIU, Xin XIANG, Liang-zhao CHU, Yi-min CHEN, Ming-hao DONG, Hua YANG   +8 more
doaj  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A Theoretical Approach to Dual Practice Regulations in the Health Sector [PDF]

Internationally, there is wide cross-country heterogeneity in government responses to dual practice in the health sector. This paper provides a uniform theoretical framework to analyze and compare some of the most common regulations.
Paula González, Inés Macho-Stadler
core  

Referral practices of rural primary care physicians for patients with depression [PDF]

, 2001
Plan BThis research characterizes the treatment and referral practices of rural primary care physicians for their patients with depression. A mailed survey was sent to all practicing physicians in rural Jackson County, Wisconsin and surrounding areas ...
Wentz, Meridith K.
core  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

How Payment Systems Affect Physicians' Provision Behaviour – An Experimental Investigation [PDF]

Understanding how physicians respond to incentives from payment schemes is a central concern in health economics research. We introduce a controlled laboratory experiment to analyse the influence of incentives from fee-for-service and capitation payments
Reinhard Selten, Heike Hennig-Schmidt, Daniel Wiesen   +2 more
core  

Does academic practice protect emergency physicians against burnout?

, 2020
Burnout is a complex syndrome thought to result from long‐term exposure to career‐related stressors. Physicians are at higher risk for burnout than the general United States (US) working population, and emergency medicine has some of the highest burnout ...
Lauren A. Walter, Norvell, Jeffrey G., Carlberg, David J., Bruce M. Lo, Lo, Bruce M., Brooke M. Moungey, Jeffrey G. Norvell, Finnell, John T., Dziedzic, Jacqueline M., Diller, David, Baker, Annalee M., David J. Carlberg, Schiller, Elizabeth, Annalee M. Baker, Chad Kessler, Elizabeth Schiller, Moungey, Brooke M., Greenberger, Sarah, Sarah Greenberger, David Diller, Jacqueline M. Dziedzic, John T. Finnell, Kessler, Chad, Walter, Lauren A.   +23 more
core   +1 more source