Results 161 to 170 of about 14,651,094 (400)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

An evaluation of knowledge, attitudes, practice, and associated factors regarding oxygen therapy among resident doctors in a tertiary care teaching hospital: A mixed-methods study

open access: yesJournal of Education and Health Promotion
BACKGROUND: Despite oxygen therapy guidelines, suboptimal practices prevail among front-line resident doctors, highlighting knowledge and attitudinal barriers. Mixed-methods research can inform tailored quality improvements.
M Yogesh   +3 more
doaj   +1 more source

Clinical Practice Patterns of Intravitreal Anti-Vascular Endothelial Growth Factor Injections in Treatment of Patients with Diabetic Macular Edema: A Retrospective Study

open access: green, 2021
Nida Safdar   +7 more
openalex   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Wash Corporate Heads! Business Practice can be Changed via the Dispositions of Executives: Re-socialization towards Implicit Eco-sustainability [PDF]

open access: yes
The present paper is the synopsis of my doctoral dissertation, which assumes that – in addition to rational factors – the dispositions of management also decisively affect business decisions, and thus business executives' mindset and behavioral patterns (
Hrotko, Timur
core   +1 more source

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