Results 121 to 130 of about 8,841,562 (288)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Development of palliative care clinical practice guidelines and referral care pathways for primary care practitioners in Pakistan

BMC Palliative Care
Background Despite a large burden of life-limitingillness, there exists a dearth of services of palliative care in Pakistan. International guidelines have questionable applicability in Pakistan due to the socioeconomic differences.
Syeda Amrah Hashmi, Russell Seth Martins, Annum Ishtiaq, Nashia Ali Rizvi, Mohsin Ali Mustafa, Alina Pervez, Ayra Siddiqui, Syeda Fatima Shariq, Sarah Nadeem, Adil H. Haider, Muhammad Atif Waqar   +10 more
doaj   +1 more source

Assessing the influence of financial management practices on organizational performance of small- and medium-scale enterprises [PDF]

Frank Nana Kweku Otoo
openalex   +1 more source

Totality of evidence in trials of sodium–glucose co-transporter-2 inhibitors in the patients with heart failure with reduced ejection fraction: implications for clinical practice [PDF]

, 2020
Javed Butler, Faı̈ez Zannad, Gerasimos Filippatos, Stefan D. Anker, Milton Packer   +4 more
openalex   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Perception of fever and management practices by parents of pediatric patients

, 2013
Ravi Prakash Agrawal, Santokh Bhatia, Anil Kaushik, Chandra Bhushan Sharma   +3 more
openalex   +2 more sources

RARE-Bestpractices: a platform for sharing best practices for the management of rare diseases [PDF]

, 2014
Domenica Taruscio, Cristina Morciano, Paola Laricchiuta, Pierpaolo Mincarone, Fiorentina Palazzo, Carlo Giacomo Leo, Saverio Sabina, Riccardo Guarino, J Auld, Thomas Sejersen, Desirée Gavhed, Karen Ritchie, Michele Hilton Boon, Jan Manson, P. Kanavos, David Tordrup, Victoria Tzouma, Yann Le Cam, Juliette Senecat, Graziella Filippini, Silvia Minozzi, Cinzia Del Giovane, Holger J. Schünemann, Joerg J Meerpohl, Barbara Prediger, Lisa Schell, Румен Стефанов, Георги Искров, Цонка Митева-Катранджиева, Pedro Serrano‐Aguilar, Lilisbeth Perestelo‐Pérez, MM Trujillo-Martín, José Pérez-Ramos, Amado Rivero‐Santana, Angela Brand, Henk van Kranen, K. Bushby, António Atalaia, Jos� Ramet, Liesbeth Siderius, Manuel Posada de la Paz, Ignacio Abaitua-Borda, Vı́tor F. Ferreira, Manuel Hens-Pérez, FJ Manzanares   +44 more
openalex   +1 more source

Current practice focus trends in physical medicine and rehabilitation [PDF]

, 2023
Carolyn L. Kinney, David W. Pruitt, Gerard E. Francisco, Mikaela M. Raddatz, Sunil Sabharwal   +4 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source