Results 61 to 70 of about 24,669 (243)

Maternal influenza vaccination during pregnancy and risk of autism spectrum disorder in the offspring

JCPP Advances, EarlyView.
Abstract Background Vaccination has been proposed as a potential risk factor for autism spectrum disorder (ASD), contributing to public hesitancy and mistrust toward immunization. Influenza vaccination during pregnancy is considered safe and effective in preventing serious maternal complications and adverse birth outcomes associated with influenza ...
Shahar Neeman, Maor Hemo, Gal Meiri, Dorit Shmueli, Idan Menashe   +4 more
wiley   +1 more source

Hyperphagia and impulsivity: use of self-administered Dykens’ and in-house impulsivity questionnaires to characterize eating behaviors in children with severe and early-onset obesity

Orphanet Journal of Rare Diseases
Background The determinants of early-onset obesity ( International Obesity Task Force [IOTF] 30) of different etiologies (hypothalamic obesity [HO], intellectual disability with obesity [IDO], common polygenic obesity [CO]) were prospectively included ...
Lara Arnouk, Hélène Chantereau, Sophie Courbage, Patrick Tounian, Karine Clément, Christine Poitou, Béatrice Dubern   +6 more
doaj   +1 more source

Functional constipation in children and young adults with Prader–Willi syndrome

JPGN Reports, EarlyView.
Abstract Objectives Prader–Willi Syndrome (PWS) is characterized by hyperphagia, endocrinopathies, and gastrointestinal abnormalities. Clinical concerns about constipation and fecal incontinence (FI) are common, but no studies to date have clear data on functional defecation disorders in children with PWS.
Melinda J. Pierce, Isabella Niu, Lusine Ambartsumyan, Parisa Salehi   +3 more
wiley   +1 more source

A Transcriptomic Signature of the Hypothalamic Response to Fasting and BDNF Deficiency in Prader-Willi Syndrome

Cell Reports, 2018
Summary Transcriptional analysis of brain tissue from people with molecularly defined causes of obesity may highlight disease mechanisms and therapeutic targets. We performed RNA sequencing of hypothalamus from individuals with Prader-Willi syndrome (PWS)
Elena G. Bochukova, Elena G. Bochukova, K. Lawler, Sophie Croizier, Sophie Croizier, Sophie Croizier, J. Keogh, N. Patel, G. Strohbehn, K. Lo, J. Humphrey, A. Hokken-Koelega, L. Damen, S. Donze, Sebastien G Bouret, Sebastien G Bouret, V. Plagnol, I. Farooqi   +17 more
semanticscholar   +1 more source

Prader-Willi syndrome: endocrine manifestations and management

Archives of Endocrinology and Metabolism, 2020
Prader-Willi syndrome (PWS) is a genetic disorder caused by the absence of gene expression in the 15q11.2-q13 paternal chromosome. Patients with PWS develop hypothalamic dysfunction that can lead to various endocrine changes such as: obesity, growth ...
C. Alves, R. Franco
semanticscholar   +1 more source

Use of Glucagon‐Like Peptide‐1 Receptor Agonists in Danish Adolescents and Young Adults 2018–2025

Obesity, EarlyView.
ABSTRACT Objective Use of glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) has increased rapidly following approval for obesity treatment, but data on their use in younger populations remain limited. We examined trends in GLP‐1RA use among 12– to 24‐year‐olds in Denmark during 2018–2025.
Helene Kildegaard, Jacob Harbo Andersen, Rebecca Kofod Vinding, Julie Tonsgaard Kloppenborg, Anton Pottegård   +4 more
wiley   +1 more source

Hypothalamic loss of Snord116 recapitulates the hyperphagia of Prader-Willi syndrome

Journal of Clinical Investigation, 2018
Profound hyperphagia is a major disabling feature of Prader-Willi syndrome (PWS). Characterization of the mechanisms that underlie PWS-associated hyperphagia has been slowed by the paucity of animal models with increased food intake or obesity. Mice with
Joseph Polex-Wolf, B. Lam, R. Larder, J. Tadross, D. Rimmington, F. Bosch, V. J. Cenzano, E. Ayuso, Marcella K. Ma, K. Rainbow, A. Coll, S. O’Rahilly, G. Yeo   +12 more
semanticscholar   +1 more source

Monogenic and syndromic obesity in children: Clinical recognition, genetics, and precision management

Pediatric Investigation, EarlyView.
Monogenic and syndromic obesity in children often arises from defects in the leptin–melanocortin pathway. Understanding these rare genetic causes not only clarifies mechanisms of appetite regulation but also enables precision therapies, offering hope beyond lifestyle interventions.
Hadel Khalil, Eugene Feigin, Hussein Zaitoon   +2 more
wiley   +1 more source

Circulating Irisin in Children and Adolescents With Prader-Willi Syndrome: Relation With Glucose Metabolism

Frontiers in Endocrinology, 2022
Irisin is a myokine involved in the browning of white adipose tissue and regulation of energy expenditure, glucose homeostasis and insulin sensitivity. Debated evidence exists on the metabolic role played by irisin in children with overweight or obesity,
Stefania Mai, Danilo Fintini, Chiara Mele, Alessio Convertino, Sarah Bocchini, Graziano Grugni, Gianluca Aimaretti, Roberta Vietti, Massimo Scacchi, Massimo Scacchi, Antonino Crinò, Paolo Marzullo, Paolo Marzullo   +12 more
doaj   +1 more source

High levels of caregiver burden in Prader-Willi syndrome

PLoS ONE, 2018
Objectives Prader-Willi syndrome (PWS) is a rare genetic neurodevelopmental disorder that is characterized by hyperphagia, developmental delay, incomplete sexual development, mild-to-moderate intellectual disability, and a variety of challenging ...
N. Kayadjanian, L. Schwartz, E. Farrar, K. Comtois, T. Strong   +4 more
semanticscholar   +1 more source