Results 71 to 80 of about 24,669 (243)

Metabolic Risk Factors Are Associated With Weight Status Change Over Four Years in Children Aged 4–6 Years With Obesity

Acta Paediatrica, EarlyView.
ABSTRACT Aim It is unclear how early childhood obesity treatment affects metabolic risk. This study assessed long‐term metabolic health in children with obesity aged 4–6 years and examined associations with weight status. Methods This prospective cohort study pooled data from the Sweden‐based More and Less randomized controlled trial, which compared a ...
Markus Brissman, Anna Ek, Stella Wennborg, Karin Nordin, Karin Eli, Annika Janson, Paulina Nowicka   +6 more
wiley   +1 more source

Current Treatments for Patients with Genetic Obesity

JCRPE, 2023
Obesity derives from impaired central control of body weight, implying interaction between environment and an individual genetic predisposition. Genetic obesities, including monogenic and syndromic obesities, are rare and complex neuro-endocrine ...
Nathan Faccioli, Christine Poitou, Karine Clément, Béatrice Dubern   +3 more
doaj   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Oxytocin treatment in children with Prader–Willi syndrome: A double-blind, placebo-controlled, crossover study

American Journal of Medical Genetics. Part A, 2017
Prader–Willi syndrome (PWS) is a rare, complex multisystem genetic disorder which includes hypothalamic dysfunction, hyperphagia, cognitive and behavioral problems, increased anxiety, and compulsive behaviors.
Jennifer L Miller, R. Tamura, M. Butler, V. Kimonis, Carlos R. Sulsona, J. Gold, D. J. Driscoll   +6 more
semanticscholar   +1 more source

Prader-Willi syndrome: reflections on seminal studies and future therapies

Open Biology, 2020
Prader-Willi syndrome (PWS) is caused by the loss of function of the paternally inherited 15q11-q13 locus. This region is governed by genomic imprinting, a phenomenon in which genes are expressed exclusively from one parental allele.
Michael S. Chung, Maéva Langouët, S. Chamberlain, G. Carmichael   +3 more
semanticscholar   +1 more source

Spectrum of Hypogonadism and Its Management in Adolescents With Prader‐Willi Syndrome: A Retrospective Cohort Study Over 35 Years

Clinical Endocrinology, Volume 105, Issue 1, Page 51-59, July 2026.
ABSTRACT Context Adult data indicate that hypogonadism is underdiagnosed and undertreated in Prader‐Willi Syndrome (PWS). Objectives We aimed to describe the spectrum of pubertal development, and the diagnosis and treatment of hypogonadism in paediatric/adolescent patients with PWS. Design/Patients A retrospective cohort study of patients with PWS aged
Helen Nguyen, Geoffrey Ambler, Yoon Hi Cho   +2 more
wiley   +1 more source

Challenges in Diagnosing Central Adrenal Insufficiency in Children: Cortisol‐Stimulating Tests are Safe and Often Required

Clinical Endocrinology, EarlyView.
ABSTRACT Introduction The accuracy and safety of cortisol‐stimulating tests (CSTs) for assessing hypothalamic–pituitary–adrenal (HPA) axis integrity, including the diagnosis of central adrenal insufficiency (CAI), in children remain uncertain. Although these tests can simultaneously evaluate cortisol and growth hormone secretion, the present study ...
Mariana Peduti Halah, Ana Carolina Maia Teodózio, Davi Casale Aragon, Paula Conde Lamparelli Elias, Margaret de Castro, Ayrton Custodio Moreira, Sonir Rauber Antonini   +6 more
wiley   +1 more source

Early oxytocin treatment in infants with Prader–Willi syndrome is safe and is associated with better endocrine, metabolic and behavioral outcomes

Orphanet Journal of Rare Diseases
Background Oxytocin (OT) plays an important role in modulating behavior, social interactions and feeding. Prader–Willi syndrome (PWS), a rare genetic neurodevelopmental disorder, is a model of hypothalamic disorder including OT dysfunction. We previously
Marion Valette, Gwenaelle Diene, Mélanie Glattard, Julie Cortadellas, Catherine Molinas, Sandy Faye, Grégoire Benvegnu, Kader Boulanouar, Pierre Payoux, Jean-Pierre Salles, Catherine Arnaud, Sophie Çabal, Maithé Tauber   +12 more
doaj   +1 more source

Expanding Spectrum of FIG4‐Related Neurological Disorders of Lysosomal Homeostasis: Case Report and Overview of the Potential Genotype–Phenotype Correlations

Clinical Genetics, EarlyView.
FIG4 is essential for lysosomal homeostasis. FIG4‐related disorders present as a continuous spectrum from the juvenile lethality in Yunis‐Varon syndrome to an increased risk of amyotrophic lateral sclerosis (ALS) in adult life. FIG4‐related disorders comprise a novel group of disorders of lysosomal homeostasis and can be classified into severe ...
Pankaj Prasun, Matthew Rasberry
wiley   +1 more source

Lennox-gastaut syndrome in a pediatric patient with prader-willi syndrome: A case report and review

Brain Disorders
Prader-Willi Syndrome is typically caused by paternal deletion of chromosome 15q11-q13. It involves multiple systems and is commonly associated with hypotonia, global developmental delay, and endocrine abnormalities. Seizures are less frequently reported
Raidah Albaradie, Sharook Alhawaj, Wojod Alothman, Shahid Bashir   +3 more
doaj   +1 more source