Results 81 to 90 of about 15,704 (225)

Monogenic and syndromic obesity in children: Clinical recognition, genetics, and precision management

Pediatric Investigation, EarlyView.
Monogenic and syndromic obesity in children often arises from defects in the leptin–melanocortin pathway. Understanding these rare genetic causes not only clarifies mechanisms of appetite regulation but also enables precision therapies, offering hope beyond lifestyle interventions.
Hadel Khalil, Eugene Feigin, Hussein Zaitoon   +2 more
wiley   +1 more source

Prader-Willi-like phenotype in fragile X syndrome [PDF]

, 1994
Prader-Willi-like phenotype in fragile X syndrome. Schrander-Stumpel C, Gerver WJ, Meyer H, Engelen J, Mulder H, Fryns JP. Department of Clinical Genetics, Maastricht University Hospital, The Netherlands.
Frijns, J.P., Gerver, W.J.M., Mulder, H., Schrander-Stumpel, C.T.R.M., Meyer, H., Engelen, J.J.M.   +5 more
core   +1 more source

Metabolic Risk Factors Are Associated With Weight Status Change Over Four Years in Children Aged 4–6 Years With Obesity

Acta Paediatrica, EarlyView.
ABSTRACT Aim It is unclear how early childhood obesity treatment affects metabolic risk. This study assessed long‐term metabolic health in children with obesity aged 4–6 years and examined associations with weight status. Methods This prospective cohort study pooled data from the Sweden‐based More and Less randomized controlled trial, which compared a ...
Markus Brissman, Anna Ek, Stella Wennborg, Karin Nordin, Karin Eli, Annika Janson, Paulina Nowicka   +6 more
wiley   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Early oxytocin treatment in infants with Prader–Willi syndrome is safe and is associated with better endocrine, metabolic and behavioral outcomes

Orphanet Journal of Rare Diseases
Background Oxytocin (OT) plays an important role in modulating behavior, social interactions and feeding. Prader–Willi syndrome (PWS), a rare genetic neurodevelopmental disorder, is a model of hypothalamic disorder including OT dysfunction. We previously
Marion Valette, Gwenaelle Diene, Mélanie Glattard, Julie Cortadellas, Catherine Molinas, Sandy Faye, Grégoire Benvegnu, Kader Boulanouar, Pierre Payoux, Jean-Pierre Salles, Catherine Arnaud, Sophie Çabal, Maithé Tauber   +12 more
doaj   +1 more source

Prader-Willi Syndrome [PDF]

My Signature Honors Project revolved around my younger sister and her rare genetic condition, Prader-Willi Syndrome.
Daley SF, Fermin Gutierrez MA, Mendez MD.   +2 more
europepmc   +1 more source

Challenges in Diagnosing Central Adrenal Insufficiency in Children: Cortisol‐Stimulating Tests are Safe and Often Required

Clinical Endocrinology, EarlyView.
ABSTRACT Introduction The accuracy and safety of cortisol‐stimulating tests (CSTs) for assessing hypothalamic–pituitary–adrenal (HPA) axis integrity, including the diagnosis of central adrenal insufficiency (CAI), in children remain uncertain. Although these tests can simultaneously evaluate cortisol and growth hormone secretion, the present study ...
Mariana Peduti Halah, Ana Carolina Maia Teodózio, Davi Casale Aragon, Paula Conde Lamparelli Elias, Margaret de Castro, Ayrton Custodio Moreira, Sonir Rauber Antonini   +6 more
wiley   +1 more source

Relationships between Sensory Processing, Aberrant Behaviors and Food-related Behaviors in Individuals with Prader-Willi Syndrome [PDF]

, 2019
Objective：The level of sensory processing dysfunction was examined and compared with the severity of food-related behaviors and aberrant behaviors in 102 individuals（60 males and 42 females）with Prader-Willi syndrome（PWS）, including 76 patients with ...
Ishii, Atsushi, Ihara, Hiroshi, Gito, Masao, Oto, Yuji, Takahashi, Asami, Ogata, Hiroyuki, Saima, Sohei, Nagai, Toshiro, Murakami, Nobuyuki   +8 more
core   +1 more source

Prader-Willi Syndrome (PWS) [PDF]

, 1970
An eleven-year-old boy reported with increasing body weight and appetite since birth. He is suffering from insulin dependent diabetes since ten years of age and underwent extensive investigation including MRI of brain.
MS Islam, S Hamid, ZI Chowdhury
core   +1 more source

Expanding Spectrum of FIG4‐Related Neurological Disorders of Lysosomal Homeostasis: Case Report and Overview of the Potential Genotype–Phenotype Correlations

Clinical Genetics, EarlyView.
FIG4 is essential for lysosomal homeostasis. FIG4‐related disorders present as a continuous spectrum from the juvenile lethality in Yunis‐Varon syndrome to an increased risk of amyotrophic lateral sclerosis (ALS) in adult life. FIG4‐related disorders comprise a novel group of disorders of lysosomal homeostasis and can be classified into severe ...
Pankaj Prasun, Matthew Rasberry
wiley   +1 more source