Results 81 to 90 of about 6,694,831 (167)

The New Era of Respiratory Syncytial Virus Protection for Infants: A Mini Review of Current Tools for Immunoprophylaxis

Acta Paediatrica, EarlyView.
ABSTRACT Aim This mini review describes the history of infant respiratory syncytial virus (RSV) immunoprophylaxis and the latest advances in this area. It also reviews the efficacy, safety and impact of the recently introduced prophylactic strategies. Method This narrative review is based on a targeted review of published literature, with emphasis on ...
Santtu Heinonen, Pekka Vartiainen
wiley   +1 more source

Acting on the Voicelessness Challenge to Democratic Deliberation: A Six‐Actor Framework

Bioethics, EarlyView.
ABSTRACT Political philosophers have long recognized that key stakeholders in policy decisions—children, future generations, nonhuman animals, and individuals with severe cognitive impairments—are structurally unable to participate in the deliberative processes meant to legitimate those decisions.
Julian C. Jamison
wiley   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Lifestyle Management in Menopause: A Systematic Review of Women With Premature Ovarian Insufficiency

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Premature ovarian insufficiency (POI), the loss of ovarian function before age 40, increases the risk of cardiovascular disease, low bone mineral density, dementia and psychological distress. Lifestyle interventions reduce chronic disease risk in other populations and, with hormone therapy, may improve health outcomes in POI.
Ladan Yeganeh, Nathalie Vermeulen, Carolyn Ee, Helena Teede, Amanda J. Vincent   +4 more
wiley   +1 more source

Segmented Intraoral Scanning With a Palatal Marker for Complete‐Arch Digital Implant Impressions: An In Vitro Comparative Study

Clinical Oral Implants Research, EarlyView.
ABSTRACT Objectives To compare four complete‐arch implant impression workflows—segmented right/left IOS merged via a palatal marker (IOS‐LEGO‐Seg), continuous full‐arch IOS with a palatal marker (IOS‐LEGO‐Full), continuous full‐arch IOS without a palatal marker (IOS‐Full), and a conventional open‐tray PVS impression followed by cast fabrication and ...
Reo Ikumi, Takahiro Murakami, Luís Azevedo, João Pitta, Duygu Karasan, Irena Sailer   +5 more
wiley   +1 more source

Guidance on artificial intelligence use for rapid evidence mapping of early childhood intervention outcome measures

Developmental Medicine &Child Neurology, EarlyView.
Aim To synthesize research evidence on the psychometric properties of outcome measures alongside practical implementation considerations relevant to children, families, practitioners, and services, and produce evidence‐based practice resources to support clinical decision‐making in outcome measurement for the early childhood intervention (ECI) context.
Suzanne H. Long, Anita L. D'Aprano, Francesca Lami, Meghan R. Wilson, Sarah J. Knight, Miriam J. Yates, Christine Imms   +6 more
wiley   +1 more source

Parastomal Hernia: Rethinking Prevention and Repair in Contemporary Colorectal Surgery

ANZ Journal of Surgery, EarlyView.
Rathin Gosavi, Thang Chien Nguyen, Paul McMurrick, William Teoh, Vignesh Narasimhan   +4 more
wiley   +1 more source

Organized sports‐based interventions and motor outcomes in children diagnosed with autism spectrum disorder: A systematic review

Developmental Medicine &Child Neurology, EarlyView.
Organized sports‐based interventions show promise for improving motor skills in children with ASD, particularly martial arts and aquatic training, but stronger evidence form higher‐quality studies is needed. Abstract Aim To evaluate the effectiveness of organized sports‐based interventions on motor outcomes in children with autism spectrum disorder ...
Kailash Ram, Maeren Hill, Caitlyn Stewart, Kaitlin Hardy, Sonia Khurana   +4 more
wiley   +1 more source

Implementing a pragmatic clinical trial to tailor opioids for chronic pain on behalf of the IGNITE ADOPT PGx investigators

Chronic pain is a prevalent condition with enormous economic burden. Opioids such as tramadol, codeine, and hydrocodone are commonly used to treat chronic pain; these drugs are activated to more potent opioid receptor agonists by the hepatic CYP2D6 ...
Park, Haesuk, Cavallari, Larisa A., Skaar, Todd C., Pratt, Victoria M., IGNITE Pragmatic Trials Network, Orlando, Lori, Van Driest, Sara, Fillingim, Roger B., Myers, Rachel A., Shuman, Saskia, Voora, Deepak, Chakraborty, Hrishikesh, Elwood, Erica N., Singh, Rajbir, Sadeghpour, Azita, Rosenman, Marc, Peterson, Josh F., Johnson, Julie A., Obeng, Aniwaa Owusu, Cicali, Emily, Eadon, Michael T., Nguyen, Khoa A., Lynch, Sheryl, Horowitz, Carol R., Dexter, Paul R., Winterstein, Almut G., Wiisanen, Kristin, Volpi, Simona, Tillman, Emma M., Ginsburg, Geoffrey S., Callaghan, John T.   +30 more
core   +1 more source