Results 61 to 70 of about 7,099,508 (221)

The Pragmatic Turn in Clinical Research: in Search for the Real World

, 2021
How does knowledge obtained in clinical trials apply to the actual treatment of patients? This question has recently acquired a new significance amidst complaints about the limited ability of trial results to improve clinical practice. Pragmatic clinical
Zvonareva, O., Zvonareva, Olga, Olga Zvonareva   +2 more
core   +1 more source

Artificial Intelligence in Dermatology: Current Applications and Future Directions

JEADV Clinical Practice, EarlyView.
This scoping review of 56 studies maps AI applications in dermatology. Image‐based classification for skin cancer detection dominates (48%), followed by clinical decision support (21%), teledermatology triage (11%), and predictive analytics (11%). While deep learning algorithms demonstrate diagnostic performance comparable to clinicians in controlled ...
Sofía Pérez‐Lalinde, Francisco Flores   +1 more
wiley   +1 more source

Implementing a pragmatic clinical trial to tailor opioids for chronic pain on behalf of the IGNITE ADOPT PGx investigators

Chronic pain is a prevalent condition with enormous economic burden. Opioids such as tramadol, codeine, and hydrocodone are commonly used to treat chronic pain; these drugs are activated to more potent opioid receptor agonists by the hepatic CYP2D6 ...
Park, Haesuk, Cavallari, Larisa A., Skaar, Todd C., Pratt, Victoria M., IGNITE Pragmatic Trials Network, Orlando, Lori, Van Driest, Sara, Fillingim, Roger B., Myers, Rachel A., Shuman, Saskia, Voora, Deepak, Chakraborty, Hrishikesh, Elwood, Erica N., Singh, Rajbir, Sadeghpour, Azita, Rosenman, Marc, Peterson, Josh F., Johnson, Julie A., Obeng, Aniwaa Owusu, Cicali, Emily, Eadon, Michael T., Nguyen, Khoa A., Lynch, Sheryl, Horowitz, Carol R., Dexter, Paul R., Winterstein, Almut G., Wiisanen, Kristin, Volpi, Simona, Tillman, Emma M., Ginsburg, Geoffrey S., Callaghan, John T.   +30 more
core   +1 more source

Composite Inflammatory Score for Predicting Progression‐Free Survival in Metastatic Clear Cell Renal Cell Carcinoma Treated With First‐Line Toripalimab Plus Axitinib

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Routine inflammatory and nutritional markers may help stratify progression risk in metastatic clear cell renal cell carcinoma during immunotherapy‐based treatment. This single‐center retrospective study included 237 patients who received first‐line toripalimab plus axitinib therapy.
Yun‐Feng Wu, Jing‐Suo Wang, Chuan‐Ao Zhang, Fan Zhang, Zhi‐Yu Zhang   +4 more
wiley   +1 more source

Palliative radiotherapy in addition to self-expanding metal stent for improving dysphagia and survival in advanced oesophageal cancer (ROCS: Radiotherapy after Oesophageal Cancer Stenting):study protocol for a randomized controlled trial [PDF]

, 2014
BackgroundThe single most distressing symptom for patients with advanced esophageal cancer is dysphagia. Amongst the more effective treatments for relief of dysphagia is insertion of a self-expanding metal stent (SEMS).
Douglas Adamson, Nixon, Lisette, Tom Crosby, Hurt, Chris, Jane Blazeby, Anthony Byrne, Crosby, Tom, Byrne, Anthony, Mim Evans, David Cohen, Adamson, Douglas, Blazeby, Jane, Gareth Griffiths, Fitzgibbon, Jim, Lisette Nixon, Cohen, David, Chris Hurt, Evans, Mim, Noreen Hopewell Kelly, Griffiths, Gareth, Nelson, Annmarie, Jim Fitzgibbon, Kelly, Noreen Hopewell, Staffurth, John, Hopewell Kelly, Noreen, John Staffurth, et al., Annmarie Nelson   +27 more
core   +2 more sources

Concomitant cartilage restoration does not demonstrate consistent additional clinical benefit in medial patellofemoral ligament reconstruction: A systematic review

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose This review specifically evaluates whether the presence of cartilage lesions, or their surgical treatment, modifies the clinical benefit of medial patellofemoral ligament (MPFL) reconstruction. Methods A systematic review was conducted following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta‐Analyses) guidelines ...
Dave Osinachukwu Duru, Djamel Wade, Marc Daniel Bouchard, Prushoth Vivekanantha, Shahbaz S. Malik, Nathan Wm Skelley, Bryson P. Lesniak, Darren de Sa   +7 more
wiley   +1 more source

Hamstring graft remodelling after ACL reconstruction is slower in paediatric population compared to adults

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Anterior cruciate ligament (ACL) injuries are increasing in children and adolescents and reconstruction (ACLR) is now frequently performed in this population. Paediatric patients remain at higher risk of reinjury, possibly due to delayed graft remodelling.
Caroline de Pesters, Nicolas Vari, Emilie Bérard, Estelle Maupoint, Linda Staali, Marie Faruch, Etienne Cavaignac, Franck Accadbled   +7 more
wiley   +1 more source

Warwick hip trauma study : a randomised clinical trial comparing interventions to improve outcomes in internally fixed intracapsular fractures of the proximal femur : protocol for The WHiT Study [PDF]

, 2010
Background Controversy exists regarding the optimal treatment for patients with displaced intracapsular fractures of the proximal femur. The recognised treatment alternatives are arthroplasty and internal fixation.
Costa, Matthew L., Parsons, Nicholas R., Achten, Juul, Griffin Xavier, Nick Parsons, Achten, J, Matthew L Costa, Griffin, Xavier L., Costa, ML, Parsons Nick, Achten Juul, Parsons, N, Costa Matthew L, Juul Achten, Griffin, XL, Xavier Luke Griffin   +15 more
core   +2 more sources

Disease‐Duration–Specific Percentiles for Prospective Subtyping of Parkinson's Disease: A PPMI‐Based Study

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's disease (PD) is clinically heterogeneous, with variable progression rates that complicate clinical trial design. The data‐driven diffuse malignant (DM), intermediate (IM), and mild‐motor predominant (MMP) subtyping model has prognostic value but lacks disease duration–specific thresholds for prospective use in disease ...
Ahmed Negida, Nitai Mukhopadhyay, Brian D. Berman, Seyed‐Mohammad Fereshtehnejad, Matthew J. Barrett   +4 more
wiley   +1 more source

Non‐Invasive Triage of Bladder Outlet Obstruction and Detrusor Underactivity in Men With Lower Urinary Tract Symptoms: A Narrative Review and Conceptual Framework for Depth‐Aware Multimodal Transcutaneous Testing

Neurourology and Urodynamics, EarlyView.
ABSTRACT Introduction Differentiating bladder outlet obstruction (BOO) from detrusor underactivity (DU) remains a major unmet need in the management of lower urinary tract symptoms in men. Although pressure–flow urodynamics provide a definitive physiological classification, their invasiveness limits their widespread use.
Sehwan Kim, Bryan K. Kim, John T. Stoffel, Aram Kim   +3 more
wiley   +1 more source