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Pragmatic Clinical Trials in Osteoporosis
Current Osteoporosis Reports, 2019In this review, we present the application of pragmatic clinical trials for evaluating interventions in osteoporosis, and we discuss methodological considerations for designing and conducting a pragmatic clinical trial compared with a classical randomized clinical trial.Pragmatic clinical trials are a popular study design testing effectiveness of ...
Adami, Giovanni +2 more
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Untapped Potential? Representativeness in Pragmatic Clinical Trials
JAMAThis JAMA Viewpoint explores the potential of pragmatic clinical trials to improve demographic representativeness and health equity in clinical research.
Caleigh, Propes +2 more
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Pragmatic Patient Engagement in Designing Pragmatic Oncology Clinical Trials
Future Oncology, 2021Oncology trials are the cornerstone of effective and safe therapeutic discoveries. However, there is increasing demand for pragmatism and patient engagement in the design, implementation and dissemination of oncology trials. Many researchers are uncertain about making trials more practical and even less knowledgeable about how to meaningfully engage ...
Bernard Bright Davies-Teye +4 more
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Partial Entrustment in Pragmatic Clinical Trials
The American Journal of Bioethics, 2020Morain et al. (2020) tackle the difficult and fascinating question of how researchers and health systems should manage individual-level “collateral” (i.e., incidental or secondary) findings (CFs) a...
Henry S. Richardson, Mildred K. Cho
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Research and scholarly methods: Pragmatic clinical trials
JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, 2021AbstractPragmatic clinical trials (PCTs) have received increased attention within health services and pharmacy practice research due to their ability to test interventions in the real world, with emphasis on implementation and scalability in diverse practice environments.
Onyeche Oche +3 more
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A value proposition for pragmatic clinical trials
The American Journal of Managed Care, 2022The authors examine the origin, benefits, and challenges of pragmatic clinical trials to assess the ultimate value of this research design.
Lorella, Palazzo +3 more
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Pragmatic clinical trials to advance research in children and adolescents with eating disorders.
International Journal of Eating DisordersOBJECTIVE To discuss the utility of pragmatic clinical trials (PCTs) to help advance research in eating disorders (EDs). METHODS We describe challenges associated with traditional explanatory research trials and examine PCTs as an alternative ...
Mark L. Norris, W. Spettigue, N. Obeid
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Pragmatic clinical trials: Increasing the rate of translating nursing research into practice†.
Japan Journal of Nursing Science, 2020AIM Nursing research worldwide is committed to rigorous scientific inquiry that provides a significant body of knowledge to advance nursing practice.
A. Doorenbos, Yutaka Kato
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“Pragmatic” clinical trials: from whose perspective?
Annals of Internal Medicine, 2009Over the past 40 years, methodologists have become increasingly enthusiastic about conducting “pragmatic” clinical trials, which aim to simulate real-world settings as much as possible.1 In contrast to explanatory trials that are conducted under idealised circumstances, successful pragmatic trials will have the intended benefit of directly informing ...
Paul J, Karanicolas +3 more
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Ethics and Regulatory Complexities for Pragmatic Clinical Trials
JAMA, 2014Some patients do not receive the best care possible, either because research to support clinical decision making with high-quality evidence is lacking or because evidence-based practices are not routinely implemented.1 Pragmatic clinical trials (PCTs), which include patients in routine clinical practice settings and typically incorporate comparative ...
Jeremy, Sugarman, Robert M, Califf
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