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Choosing outcomes for clinical trials: a pragmatic perspective
Current Opinion in Critical Care, 2018Purpose of review The turn to evidence-based medicine in critical care has lead to a dramatic increase in the number of randomized clinical trials. Yet many of these trials are not showing differences on an appropriately prespecified primary outcome.
Theodore J, Iwashyna, Joanne, McPeake
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[Comparison of pragmatic clinical trials and explanatory clinical trials].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2010Clinical trials are often designed as either pragmatic or explanatory. The pragmatic clinical trials are generally used for measuring the effectiveness of a treatment in common clinical practice, while the explanatory trial for measuring the efficacy of a treatment under ideal conditions.
Yan-Hong, Zhang +2 more
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Expanding the role of the stroke nurse: a pragmatic clinical trial
Journal of Advanced Nursing, 2005Aims. This paper reports a study evaluating whether expanding a specialist nursing role to provide outreach education and support to stroke patients and carers after discharge from hospital is effective in promoting recovery.Background. Building therapeutic relationships with patients and carers is a key component of the nursing role in stroke ...
Burton, Christopher, Gibbon, Bernard
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Observational, Pragmatic, and Clinical Trials in Bipolar Disorder
The Journal of Clinical Psychiatry, 2008Course of illness, treatment effectiveness, and outcomes in bipolar disorder are studied in various ways, including randomized controlled clinical and pragmatic trials and observational studies. Clinical trials have important limitations that often make the application of findings difficult in real-world settings.
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Clinical trials: conventional or pragmatic?
European Journal of Heart Failure, 2022Luigi, Tavazzi +3 more
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An overview of precision oncology basket and umbrella trials for clinicians
Ca-A Cancer Journal for Clinicians, 2020Jay J H Park +2 more
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