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Pragmatic Clinical Trials in Osteoporosis
Current Osteoporosis Reports, 2019 In this review, we present the application of pragmatic clinical trials for evaluating interventions in osteoporosis, and we discuss methodological considerations for designing and conducting a pragmatic clinical trial compared with a classical randomized clinical trial.Pragmatic clinical trials are a popular study design testing effectiveness of ...
Kenneth G Saag +2 more
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Clinical Trials Overview: From Explanatory to Pragmatic Clinical Trials
Mayo Clinic Proceedings, 2023Clinical trials have been the bedrock of research to evaluate the safety and efficacy of new medical, surgical, or other interventions. Traditional "explanatory" clinical trials have aimed to explain a biological cause (new treatment) and effect (patient outcome) while controlling for many factors that might impact the evaluation, such as restricted ...
Jennifer Le-Rademacher +3 more
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A value proposition for pragmatic clinical trials
The American Journal of Managed Care, 2022The authors examine the origin, benefits, and challenges of pragmatic clinical trials to assess the ultimate value of this research design.
Lorella, Palazzo +3 more
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Partial Entrustment in Pragmatic Clinical Trials
The American Journal of Bioethics, 2020Morain et al. (2020) tackle the difficult and fascinating question of how researchers and health systems should manage individual-level “collateral” (i.e., incidental or secondary) findings (CFs) a...
Henry S. Richardson, Mildred K. Cho
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Pragmatic Patient Engagement in Designing Pragmatic Oncology Clinical Trials
Future Oncology, 2021Oncology trials are the cornerstone of effective and safe therapeutic discoveries. However, there is increasing demand for pragmatism and patient engagement in the design, implementation and dissemination of oncology trials. Many researchers are uncertain about making trials more practical and even less knowledgeable about how to meaningfully engage ...
Bernard Bright Davies-Teye +4 more
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Pragmatic Clinical Trials in Neurology
Annals of NeurologyThe need for pragmatic clinical trials evaluating therapeutic interventions in patients with neurological disease is continually increasing due to availability of multiple therapeutic interventions (comparative effectiveness), multifaceted approaches (multiple concurrent synergistic therapeutic interventions), and gaps in trial‐specific and real‐world ...
Adnan I. Qureshi +5 more
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Research and scholarly methods: Pragmatic clinical trials
JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, 2021AbstractPragmatic clinical trials (PCTs) have received increased attention within health services and pharmacy practice research due to their ability to test interventions in the real world, with emphasis on implementation and scalability in diverse practice environments.
Onyeche Oche +3 more
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Making Pragmatic Clinical Trials More Pragmatic
JAMAThis Viewpoint discusses pragmatic trials and their role in developing knowledge that can be broadly applicable throughout the health care system.
Richard, Platt +2 more
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Pragmatic Clinical Trials in Plastic Surgery
Plastic & Reconstructive SurgeryThe use of pragmatic clinical trials (PCTs) has been increasing within medical and surgical research departments, but has not yet been widely implemented in plastic surgery. PCTs are similar to randomized controlled trials (RCTs) in that they both randomize patients to treatments and follow them prospectively ...
Emily R, Geis +2 more
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Ethics and Regulatory Complexities for Pragmatic Clinical Trials
JAMA, 2014Some patients do not receive the best care possible, either because research to support clinical decision making with high-quality evidence is lacking or because evidence-based practices are not routinely implemented.1 Pragmatic clinical trials (PCTs), which include patients in routine clinical practice settings and typically incorporate comparative ...
Jeremy, Sugarman, Robert M, Califf
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