Results 111 to 120 of about 79,378 (235)

Spotlight commentary: Deprescribing in long‐term care facilities—Towards safer and smarter medication use in older adults

British Journal of Clinical Pharmacology, EarlyView.
Nataša Skočibušić, Igor Rubinić, Vera Vlahović‐Palčevski   +2 more
wiley   +1 more source

Automated CLL cell population detection using a weakly supervised approach and CLL MRD flow cytometry data

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Minimal/measurable residual disease detection is routinely performed as part of post‐diagnostic treatment plans for many types of cancer, for which multiparameter flow cytometry is one possible modality frequently used. We propose a machine learning approach for binary prediction of minimal residual disease status with flow cytometry data. Our
Wikum Dinalankara, Chandler Sy, Jiani Chai, Paul B. Barone, Luigi Marchionni, Paul D. Simonson   +5 more
wiley   +1 more source

The difficult discussion on the deactivation of implantable cardioverter devices at the end of life: a systematic review

ESC Heart Failure, Volume 12, Issue 2, Page 733-760, April 2025.
Abstract Implantable cardioverter defibrillators (ICDs) reliably prevent death due to life‐threatening arrhythmias; this may become less relevant in people with more severe heart failure who are reaching the end of life (EOL). This review aimed to explore the ICD deactivation process and identify ethical issues, especially around the initiation of ...
Siobhan C. Murray, Claire McNamara, Anna V. Chatzi   +2 more
wiley   +1 more source

Mortality risk stratification for Takotsubo syndrome: Evaluating CRP measurement alongside the InterTAK prognostic score

ESC Heart Failure, Volume 12, Issue 2, Page 1427-1436, April 2025.
Abstract Background and objectives Initially described as a benign acute cardiomyopathy, Takotsubo syndrome has been linked to elevated mortality rates. Emerging evidence suggests that unresolved myocardial inflammation may contribute to this adverse prognosis.
Loïc Faucher, Kensuke Matsushita, Shinnosuke Kikuchi, Taraneh Tatarcheh, Benjamin Marchandot, Amandine Granier, Said Amissi, Antonin Trimaille, Laurence Jesel, Patrick Ohlmann, Kiyoshi Hibi, Valérie Schini‐Kerth, Olivier Morel   +12 more
wiley   +1 more source

Improvement of Peak Integration in Capillary Electrophoresis: Reference Data Set No. 1

ELECTROPHORESIS, EarlyView.
ABSTRACT Capillary electrophoresis (CE) often provides superior separation of macromolecules such as monoclonal antibodies (mAbs), a major biopharmaceutical class, compared with liquid chromatography. However, electropherograms frequently exhibit complex baselines and peak shapes that are not reliably handled by integration algorithms designed for ...
Marlon Krompholz, Timothy Blanc, Huixin Lu, Patricia Christensen, Frédéric Ginot, Gábor Járvás, Trang D. Nguyen, Ashley Prout, Timothy Riehlman, Brian Wei, Andrei Hutanu, Steffen Kiessig, Knut Baumann, Cari E. Sänger‐van de Griend, Hermann Wätzig   +14 more
wiley   +1 more source

A call for ethical, equitable, and effective artificial intelligence to improve care for all people with epilepsy: A roadmap. A report by the ILAE Global Advocacy Council and Big Data Commission

Epilepsia, EarlyView.
Abstract The artificial intelligence (AI) revolution is upon us. It will inevitably form a central component of epilepsy workflows and patient advocacy. Therefore, it behooves us as health care providers to ride the crest of this wave and guide its direction for the benefit of all people with epilepsy.
Colin B. Josephson, Sandor Beniczky, Spiros Denaxas, Akio Ikeda, Lara Jehi, Angelina Kakooza Mwesige, Nathalie Jette, Gabriel Davis Jones, Philippe Ryvlin, Arjune Sen, Chahnez Charfi Triki, Gabriella Waters, Alla Guekht, J. Helen Cross   +13 more
wiley   +1 more source

Characterizing early behavioral and social–emotional problems in young children with SCN1A+ Dravet syndrome: Findings from the ENVISION prospective natural history study

Epilepsia, EarlyView.
Abstract Objective Dravet syndrome (DS) is the prototypic developmental and epileptic encephalopathy, characterized by drug‐resistant seizures, developmental slowing, and many other morbidities. Detailed characterization of behavioral phenotypes and social–emotional skill development are limited.
Ingrid E. Scheffer, M. Scott Perry, Joseph Sullivan, Susana Boronat, James Wheless, Andreas Brunklaus, Linda Laux, Anup D. Patel, Colin Roberts, Dennis Dlugos, Deborah Holder, Kelly Knupp, Matt Lallas, Steven Phillips, Eric Segal, Dennis Lal, Elaine Wirrell, Sameer M. Zuberi, Rebecca Shaffer, Mary Wojnaroski, Madison M. Berl, Sarah Christensen, Emma S. James, Maria Candida Vila, Norman Huang, Jacqueline S. Gofshteyn, Salvador Rico   +26 more
wiley   +1 more source

Defining the end point of status epilepticus: A scoping review and framework for standardization

Epilepsia, EarlyView.
Abstract Status epilepticus (SE) is a life‐threatening neurological emergency with consensus‐driven definitions for onset but no standardized criteria for its end point. This gap creates uncertainty in research and clinical practice. We conducted a scoping review to evaluate how end points have been defined in SE research and to identify key areas of ...
Fawad A. Khan, Margaret T. Gopaul, Samuel L. Carter, Anil Chimakurthy, Summer Skelton, Lawrence J. Hirsch, Eugen Trinka   +6 more
wiley   +1 more source

Creativity and its link to epilepsy

Epilepsia Open, EarlyView.
Abstract Creative thinking represents one of our highest‐order cognitive processes, involving multiple cortical structures and an intricate interplay between several cortical and subcortical networks. It results in novel ideas that translate to useful products or concepts. The evolutionary purpose of creativity is therefore apparent, as it advances our
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Good clinical trial funding practices: how can public funders reduce the risk of trial failure and improve health impact? [PDF]

Trials
Hulstaert F, Harrison J, Nevens H, Stocquart N, Marynen E, Pouppez C, Neyt M, Verleye L, Vrijens F.   +8 more
europepmc   +1 more source