Results 91 to 100 of about 55,432,686 (234)

Trials, Tricks and Transparency: How Disclosure Rules Affect Clinical Knowledge [PDF]

Scandals of selective reporting of clinical trial results by pharmaceutical firms have underlined the need for more transparency in clinical trials. We provide a theoretical framework which reproduces incentives for selective reporting and yields three ...
Nicolás Porteiro, Paula González, Matthias Dahm   +2 more
core  

Microbial‐Metabolite Signatures Are Associated With Glucocorticoid Responsiveness in Chronic Rhinosinusitis With Nasal Polyps

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) exhibit heterogeneous responses to oral glucocorticoids (GCs), but the biological basis of this variability remains unclear. Objective To identify gut microbiome‒plasma metabolomic signatures associated with GC responsiveness in CRSwNP patients and to compare their ...
Ying‐Ying Zhang, Xin‐Yu Ding, Mei‐Ping Lu, Yan‐Bing Chen, Ye Yuan, Lin Jiang, Min Zhang, Lei Cheng   +7 more
wiley   +1 more source

Efficacy and Predictors of Response to Biologic Therapy and Endoscopic Sinus Surgery in Patients With Nasal Polyps: A Systematic Review

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Biologics and endoscopic sinus surgery (ESS) treat refractory chronic rhinosinusitis with nasal polyposis (CRSwNP), but direct comparisons are lacking. We synthesized efficacy and subgroup data across randomized controlled trials (RCTs) of biologics and ESS.
Arun Chakravorty, Matthew E. Lin, Rory Lubner, Jess C. Mace, Jeffrey Suh, Jivianne Lee, Marilene Wang, Sarah Wise, Naweed Chowdhury, Zachary M. Soler, Justin Turner, Timothy L. Smith, Myung Sim, Daniel M. Beswick   +13 more
wiley   +1 more source

Clean Cut (adaptive, multimodal surgical infection prevention programme) for low‐resource settings: a prospective quality improvement study

BJS (British Journal of Surgery), EarlyView., 2020
Clean Cut is a multimodal, adaptive, checklist‐based infection prevention programme designed to improve compliance with six critical perioperative infection prevention practices. After introducing the programme at five hospitals in Ethiopia, compliance with critical infection prevention standards significantly improved and the relative risk of ...
J. A. Forrester, N. Starr, T. Negussie, D. Schaps, M. Adem, S. Alemu, D. Amenu, N. Gebeyehu, T. Habteyohannes, F. Jiru, A. Tesfaye, E. Wayessa, R. Chen, A. Trickey, S. Bitew, A. Bekele, T. G. Weiser   +16 more
wiley   +1 more source

Cerebral No‐Reflow after Thrombectomy: International Delphi Consensus on Definition and Imaging Assessment

Annals of Neurology, EarlyView.
Background The operational definition and imaging assessment of the no‐reflow phenomenon, a potential contributor to poor clinical outcome despite successful thrombectomy, remains debated. We aimed to develop expert‐based international consensus on the definition, assessment, and reporting standard of cerebral no‐reflow post‐thrombectomy. Methods Three‐
Adnan Mujanovic, Samantha Rivet, Adrien ter Schiphorst, Jean‐Claude Baron, Johannes Kaesmacher, Felix Ng, Cerebral No‐Reflow Delphi‐Consensus Group, Pooja Khatri, Xin Cheng, Andrea Zini, Maria Hernandez Perez, Ettore Nicolini, Marta Rubiera, Charlotte Rosso, Marie Luby, Victor Del Brutto, Christopher Favilla, Angel Chamorro, Angelika Hoffman, David Liebeskind, Sven P. R. Luijten, Moritz Hernandez Petzsche   +21 more
wiley   +1 more source

Personal benefit, or benefiting others? Deciding whether to take part in clinical trials

, 2010
Background: Participation in clinical trials is critical for the success of evidence-based healthcare. Much previous research suggests that people take part in clinical trials mostly for altruistic reasons, and that deriving personal benefit is a ...
Locock, Margaret, Lorraine Smith, Louise Locock, Locock, Louise, Smith, Lorraine, Locock, L, Smith, L   +6 more
core   +1 more source

A critical reappraisal of the carotid sinus and carotid bulb: Distinguishing neurohistological function from vascular geometry

The Anatomical Record, EarlyView.
This review redefines the carotid bulb (CB) as a variable geometric dilation shaped by hemodynamics and the carotid sinus (CS) as a conserved neurohistological baroreceptor field. Distinguishing these entities clarifies a century of anatomical confusion and links geometry, neurohistology, and clinical interpretation within a unified framework ...
Răzvan Costin Tudose, Nicolae Radu, Mugurel Constantin Rusu   +2 more
wiley   +1 more source

The petrotympanic canal (Huguier canal): Evolutionary, anatomical, and medical perspectives

The Anatomical Record, EarlyView.
Abstract The petrotympanic canal, traditionally referred to as Civinini's or Huguier's canal, represents an anatomical passage connecting the middle ear and temporomandibular joint (TMJ). Despite its early description, its structural complexity and functional significance have often been underestimated. In this study, we combined historical, anatomical,
Andrea Papini, Nicola Montemurro, Ferdinando Paternostro, Immacolata Belviso, Massimo Galli, Petra Martini, Licia Uccelli, Jacopo Moggi‐Cecchi, Gregorio Oxilia   +8 more
wiley   +1 more source

The Use of Unloader Bracing in the Management of Knee Osteoarthritis: A Modified Delphi Consensus Study

Arthroscopy, EarlyView.
Purpose To develop international expert consensus on the role of unloader bracing in the management of tibiofemoral osteoarthritis (OA) by addressing indications, contraindications, clinical evaluation, perioperative applications, and research priorities using a modified Delphi methodology.
Jonathan T. Super, Luke V. Tollefson, Iain R. Murray, Jorge Chahla, Andrew G. Geeslin, Darren L. Johnson, Ciara M. Stevenson, Robert F. LaPrade, Reykjavik Bracing Consensus Study Group, Robert F. LaPrade, Scott Anderson, Adam W. Anz, Sascha Beck, Andrew S. Bernhardson, Jorge Chahla, Anikar Chhabra, Mark E. Cinque, William M. Cregar, Pieter J. Emans, Scott C. Faucett, Andrew G. Geeslin, Darren L. Johnson, Tobias M. Jung, Patrick W. Kane, Nicholas I. Kennedy, Vickas Khanna, Cory A. Kwong, Christopher M. LaPrade, Martin Lind, Parth Lodhia, Gilbert Moatshe, Iain R. Murray, Johnathan Riboh, Anders Stalman, Ciara M. Stevenson, Wybren A. Van Der Wal, David Wasserstein, Daniel B. Whelan   +37 more
wiley   +1 more source

Unloader Bracing Is a Biomechanically Rational and Clinically Useful Intervention in Selected Patients With Tibiofemoral Joint Cartilage Pathology: A Modified Delphi Consensus Study

Arthroscopy, EarlyView.
Purpose To establish an international expert consensus on the role of unloader bracing in the management of focal tibiofemoral cartilage lesions using Delphi methodology to inform clinical decision‐making in both nonoperative and operative contexts and identify future research priorities.
Jonathan T. Super, Luke V. Tollefson, Iain R. Murray, Jorge Chahla, Andrew G. Geeslin, Darren L. Johnson, Ciara M. Stevenson, Robert F. LaPrade, Reykjavik Bracing Consensus Study Group, Robert. F. LaPrade, Scott Anderson, Adam. W. Anz, Sascha Beck, Andrew S. Bernhardson, Jorge Chahla, Anikar Chhabra, Mark E. Cinque, William M. Cregar, Pieter J. Emans, Scott C. Faucett, Andrew G. Geeslin, Darren L. Johnson, Tobias. M. Jung, Patrick. W. Kane, Nicholas I. Kennedy, Vickas Khanna, Cory A. Kwong, Christopher M. LaPrade, Martin Lind, Parth. Lodhia, Gilbert Moatshe, Iain R. Murray, Johnathan Riboh, Anders Stalman, Ciara. M. Stevenson, Wybren A. Van Der Wal, David Wasserstein, Daniel B. Whelan   +37 more
wiley   +1 more source