Results 161 to 170 of about 55,432,686 (234)

Impact of PerioperAtive LidocAine Infusions on Enhanced Recovery After Noncardiac Surgery (IMPALA-ERAS) in an inpatient setting: rationale, design and protocol for a sequential, repeated crossover trial. [PDF]

BMJ Open
Rouleau GW, Smith AW, Parrish CG, Allen LJ, Jayaram JE, Ruble SR, Adkins CM, Eden S, Shotwell MS, Yaghmour ET, Statzer NJ, Wanderer JP, Henson CP, Shams D, Kertai MD, IMPALA Investigators.   +15 more
europepmc   +1 more source

Empirical PK/PD Model for Differentiating Intrinsic Dosing Rules by Therapeutic Indication With Relevance for HIV‐1 Latency Reversal

Clinical Pharmacology &Therapeutics, EarlyView.
Romidepsin (RMD), an FDA‐approved histone deacetylase inhibitor for treating cancer, demonstrates potent latency‐reversing activity in vitro but has yielded suboptimal outcomes in kick‐and‐kill HIV‐cure trials when administered as a 5 mg/m2 infusion.
Lauren A. R. Tompkins, Amanda Poliseno, Airlie Ward, Edward P. Browne, Cassandra Gilbert, Craig Sykes, Angela D. M. Kashuba, Mackenzie L. Cottrell   +7 more
wiley   +1 more source

Longitudinal evaluation of minimally invasive protocols for the prevention and control of dental caries in Brazilian schoolchildren: a multicentre study protocol. [PDF]

BMJ Open
Bussadori SK, Santos EM, Ferri EP, Chibinski ACR, Pereira LDSV, Ribeiro CDPV, Oliveira GRC, Barbieri DSV, Duran CCG, Horliana ACRT, Motta LJ, Mesquita-Ferrari RA, Fernandes KPS, Sobral APT, Machado MA.   +14 more
europepmc   +1 more source

Model‐Informed Dose Optimization of Anakinra in Preterm Neonates Implications for Safe and Effective Dosing

Clinical Pharmacology &Therapeutics, EarlyView.
Anakinra, an interleukin‐1 receptor antagonist, shows promise for reducing inflammatory complications of premature birth. However, the pharmacokinetics (PK) of anakinra in neonates has not been characterized, limiting evidence‐based dosing. This study aimed to develop a population PK model for anakinra to guide dosing in preterm neonates.
Jia Li, David K. Metz, Elys Green, Gergely Toldi, Robert Galinsky, Megan Clark, Rebecka Atkinson, Ina Rudloff, Josephine C. Owen, Sara K. DiSimone, Samuel C. Forster, Steven X. Cho, Atif Majid, Graeme R. Polglase, Marcel Favilla, Pramod Pharande, Atul Malhotra, Calum T. Roberts, Scott H. Stansfield, Arvind Sehgal, Kenneth Tan, Alistair J. Gunn, Philip J. Berger, Alex Veldman, Rod W. Hunt, Claudia A. Nold‐Petry, Marcel F. Nold, Carl M. J. Kirkpatrick   +27 more
wiley   +1 more source

Obesity management for kidney TRANSPLANTation: protocol for the vanguard phase of an innovative randomised controlled trial, embedded in routine care (OK-TRANSPLANT 2). [PDF]

BMJ Open
Clemens KK, Irwin J, Chiu M, Dixon S, Bendo NJ, Varughese P, Vinson AJ, Lapier H, Attalla D, Ernst J, Khan T, Young A, Yau K, Craig L, Reichert S, Sener A, Moist LM.   +16 more
europepmc   +1 more source

Sustainability Assessment of Micro, Small, and Medium Enterprises: A Systematic Review and Hybrid Architecture for Credible, Salient, and Legitimate Knowledge Governance

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Sustainability assessment advances corporate social responsibility toward inclusive development. Widely recognized approaches prove inadequate for micro, small, and medium enterprises (MSMEs), resulting in fragmented proliferation that hinders cumulative knowledge.
Luísa Couto Gonçalves de Souza, Laura Proença Guimarães, Maria Auxiliadora Drumond   +2 more
wiley   +1 more source

Clinical Trials With Pragmatic Elements: A Review of Use Cases and Real-World Data Utilization

Clinical trials with pragmatic elements can capture diverse patient populations, enable efficient follow-up, and reflect routine clinical practices; yet there is limited understanding of their design features, characteristics, and use of real-world data (
PECP - Centre for Pharmacoepidemiology, Hendricks-Sturrup, Rachele, Afd Pharmacoepi & Clinical Pharmacology, Chen, Lei, Pharmacoepidemiology and Clinical Pharmacology, Su, Le, Betigeri, Seema, Dreyer, Nancy, Gardarsdottir, Helga, Burcu, Mehmet   +9 more
core  

Development and Preliminary Validation of the Turkish Prosodic Comprehension Test (PCT). [PDF]

Audiol Res
Savaş M, Tasin GMC, Kahraman Beğen S, Arslan MB, Koçak AN, Altıntaş T.   +5 more
europepmc   +1 more source

Psilocybin as a Transdiagnostic Treatment for Eating Disorders and Comorbid Psychopathology: Implications for Clinical Nosology and Research Directions

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Eating disorders (EDs) are characterized by high rates of psychiatric comorbidity and suboptimal treatment outcomes. There remain critical gaps in research, including the exploration of effective transdiagnostic interventions. This forum article examines the potential of psilocybin treatment (PT) as a transdiagnostic intervention for
Elena Koning, Jérémie Richard, Aaron Keshen   +2 more
wiley   +1 more source

The clinical and cost-effectiveness of elective primary total knee replacement with PAtellar Resurfacing compared to selective patellar resurfacing: a pragmatic multicentre randomised controlled Trial with blinding (PART) - statistical analysis plan. [PDF]

Trials
Evans RN, Judge A, Matharu GS, Petrie MJ, Blom AW, Pike K.   +5 more
europepmc   +1 more source