Results 41 to 50 of about 55,432,686 (234)

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

Series: Pragmatic trials and real world evidence: Paper 8 Data collection and management Data collection in Pragmatic Trials [PDF]

, 2017
Pragmatic trials can improve our understanding of how treatments will perform in routine practice. In a series of eight papers, the GetReal Consortium has evaluated the challenges in designing and conducting pragmatic trials and their specific ...
Matthias Egger, Egger, Matthias, Anna-Katharina Meinecke, Gaelle Nachbaur, Zuidgeest, Mira, Sven Trelle, Kafatos, George, Paco Welsing, Work Package 3 of the GetReal consortium, Burke, Des, George Kafatos, Des Burke, Trelle, Sven, Meinecke, Anna-Katharina, Maria Kubin, Nachbaur, Gaelle, Mira Zuidgeest, Welsing, Paco, Kubin, Maria, Meinecke, Anna Katharina   +19 more
core   +3 more sources

Real‐World Safety of Concomitant Colchicine and Statin Therapy

Arthritis Care &Research, EarlyView.
Objective This study aimed to evaluate the risk of clinically meaningful muscle‐ and liver‐related outcomes associated with concomitant colchicine–statin therapy in a real‐world setting, and to determine whether concomitant therapy increases the incidence of toxicity compared with either agent alone.
Roni Meidan, Ranel Loutati, Dan Caspi, Ori Elkayam, Ran Abuhasira, Tali Eviatar   +5 more
wiley   +1 more source

A limited number of medicines pragmatic trials had potential for waived informed consent following the 2016 CIOMS ethical guidelines [PDF]

, 2019
OBJECTIVE: European regulations do not allow modification or waiver of informed consent for medicines randomized controlled trials (RCTs) where the three 2016 Council for International Organizations of Medical Sciences (CIOMS) provisions are met (consent
James, S.K., de Boer, Anthonius, Stephens, Richard, Avendaño Solà, Cristina, de Boer, Anthonius,, Avendano-Sola, C., Ioannidis, J.P.A., Stephens, Richard,, Boer, A. de, Rosendaal, F.R., Stephens, R., Ioannidis, John P. A.,, Dal-Re, Rafael,, Rosendaal, Frits R.,, Afd Pharmacoepi & Clinical Pharmacology, James, Stephan K, Pharmacoepidemiology and Clinical Pharmacology, Dal Ré, Rafael, Pa Ioannidis, John, Rosendaal, Frits R, Dal-Re, R., James, Stefan,, Avendano-Sola, Cristina,   +22 more
core   +2 more sources

Longitudinal Morphomolecular Monitoring of Head and Neck Carcinogenesis

Advanced Science, EarlyView.
A miniaturized endoscopic probe that integrates Raman spectroscopy and optical coherence tomography, enabling simultaneous molecular and structural imaging of living tissue, was developed. Applied longitudinally in a mouse model of head and neck cancer, the system tracks disease progression from precancerous lesions to invasive cancer.
Jianrong Qiu, Priyanka G. Bhosale, Vishal Kumar, Jeyrroy Gabriel, Shiyue Liu, Ciro Chiappini, Richard J. Cook, Mads S. Bergholt   +7 more
wiley   +1 more source

Research Report 2011 [PDF]

, 2012
The NHMRC Clinical Trials Centre (CTC) at the University of Sydney runs large multicentre investigator-initiated clinical trials, takes part in trials of national and international collaborative trial groups and contributes expertise to trials run by ...
NHMRC Clinical Trials Centre
core  

Highlighting alcohol use in medication appointments with clinical pharmacists: the CHAMP-1 mixed methods research programme

Programme Grants for Applied Research
Background Brief interventions have been the cornerstone of alcohol prevention in the National Health Service, but there are important limitations to the underpinning evidence base, and implementation has been problematic.
Duncan Stewart, Mary Madden, Andrew Bartlett, Ranjita Dhital, Brendan Gough, Shona Haining, Ronan O’Carroll, Margaret Ogden, Cate Whittlesea, Jim McCambridge   +9 more
doaj   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Topic-specific living databases of clinical trials: A scoping review of public databases

INTRODUCTION Conducting systematic reviews of clinical trials is time-consuming and resource-intensive. One potential solution is to design databases that are continuously and automatically populated with clinical trial data from harmonised and ...
Hirt, Julian, Janiaud, Perrine, Hemkens, Lars G., Boesen, Kim   +3 more
core   +1 more source

Clinical Trials Unit Newsletter - Issue 02 [PDF]

What\u27s inside this issue: The Clinical Trials Summit of Pakistan 2025 Biosimilar trials at CTU! Completion of the Panbio Self-Test Enrolment Coming Together for Better Cancer Care Informative Snippets Clinical Trials Unit celebrates Clinical Trials ...
Clinical Trials Unit (CTU),
core   +1 more source