Results 31 to 40 of about 44,864,774 (235)

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro, Mackenzie Silverman, Maeve C. Lucas, Mariam M. Yousuf, Samuel T. Otey, Stella V. Gray, Brittany Jordan, Madeline D. Kahan, Latanya D. Agurs, Michelle Van Hirtum Das, Deborah Holder, Devin King, Eileen A. Quinn, Ryan Kammeyer, Michael S. Rafii   +14 more
wiley   +1 more source

Pragmatic disorders and their social impact [PDF]

, 2011
Pragmatic disorders in children and adults have been the focus of clinical investigations for approximately 40 years. In that time, clinicians and researchers have established a diverse range of pragmatic phenomena that are disrupted in these disorders ...
Louise Cummings, Cummings, L
core   +1 more source

Diagnosis of congenital heart diseases in children from 2D and 3D sonography using convolutional neural networks: A scoping literature review

WFUMB Ultrasound Open
Congenital heart diseases (CHDs) are the commonest congenital anomalies and a leading cause of neonatal morbidity and mortality worldwide. They affect approximately 1 % of live births globally.
Ayiga Majid, Johnes Obungoloch, Alfred Enywaku, Obeti Francis, Denis Jjuuko, Eugene Bizimana, Biryomumeisho Joshua, Wasswa William   +7 more
doaj   +1 more source

Upper Cervical Cord Area as a Biomarker of Conversion to Secondary Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study assessed whether upper cervical cord area (UCCA) measured on routine brain MRI can serve as a biomarker of conversion to SPMS. Methods This is a single‐center retrospective cohort study of RRMS patients with cross‐sectional and longitudinal analyses of clinical and MRI data. Future SPMS converters were matched by age, sex,
Nabil K. El Ayoubi, Sola Al Ghazal, Salem Hannoun, Medhat A. Siddik, Nour M. Najjar, Jim Dagher, Joseph Abboud, Myriam G. Semaan, Samia J. Khoury   +8 more
wiley   +1 more source

Advancing Stroke Clinical Trials Using Community Engagement and Implementation Science Approaches

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Stroke clinical trials are essential for advancing stroke care but can face challenges with recruitment, retention, clinical relevance, and translation into real‐world practice. We propose that integrating community engagement and implementation science approaches into stroke trials can help address these needs.
Lesli E. Skolarus, Devin L. Brown, Bernadette Boden‐Albala   +2 more
wiley   +1 more source

Intervention description is not enough: evidence from an in-depth multiple case study on the untold role and impact of context in randomised controlled trials of seven complex interventions [PDF]

, 2012
Background: A number of single case reports have suggested that the context within which intervention studies take place may challenge the assumptions that underpin randomised controlled trials (RCTs).
Brian Williams, Williams Brian, Treweek Shaun, Shaun Treweek, Taylor, Julie; id_orcid, Coyle Joanne, Taylor, Julie, Wells, Mary, Wells Mary, Mary Wells, Coyle, Joanne, Williams, Brian, Taylor Julie, Julie Taylor, Joanne Coyle, Treweek, Shaun   +15 more
core   +2 more sources

A complex behaviour change intervention delivered by dental nurses: mixed-methods fidelity assessment of the RETURN intervention

Trials
Introduction Behaviour change interventions delivered in dental settings could be useful in reducing oral health inequalities. Pragmatic randomised controlled trials testing interventions, however, are vulnerable to problems with internal and external ...
V. Lowers, P. Christiansen, B. Young, J. Hennessy, R. V. Harris   +4 more
doaj   +1 more source

Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif, Diane Demailly, Gabriella A. Horvàth, Juan Dario Ortigoza Escobar, Nathalie Dorison, Mayté Castro Jiménez, Cécile A. Hubsch, Thomas Wirth, Gun‐Marie Hariz, Sophie Huby, Morgan Dornadic, Zohra Souei, Muhammad Mushhood Ur Rehman, Simone Hemm, Mehdi Boulaymen, Eduardo M. Moraud, Jocelyne Bloch, Xavier Vasques   +17 more
wiley   +1 more source

Series: Pragmatic trials and real world evidence: Paper 8 Data collection and management Data collection in Pragmatic Trials [PDF]

, 2017
Pragmatic trials can improve our understanding of how treatments will perform in routine practice. In a series of eight papers, the GetReal Consortium has evaluated the challenges in designing and conducting pragmatic trials and their specific ...
Matthias Egger, Egger, Matthias, Anna-Katharina Meinecke, Gaelle Nachbaur, Zuidgeest, Mira, Sven Trelle, Kafatos, George, Paco Welsing, Work Package 3 of the GetReal consortium, Burke, Des, George Kafatos, Des Burke, Trelle, Sven, Meinecke, Anna-Katharina, Maria Kubin, Nachbaur, Gaelle, Mira Zuidgeest, Welsing, Paco, Kubin, Maria, Meinecke, Anna Katharina   +19 more
core   +3 more sources

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source