Results 11 to 20 of about 44,864,774 (235)

Understanding implementability in clinical trials: a pragmatic review and concept map.

, 2021
BackgroundThe translation of evidence from clinical trials into practice is complex. One approach to facilitating this translation is to consider the 'implementability' of trials as they are designed and conducted.
Australian Clinical Trials Alliance Reference Group on Impact and Implementation of CTN Trials, Sharplin, Greg, Webb, Steven A, Green, Sally, Middleton, Philippa, Cumpston, Miranda S   +5 more
core   +2 more sources

Does it matter if clinicians recruiting for a trial don't understand what the trial is really about? Qualitative study of surgeons' experiences of participation in a pragmatic multi-centre RCT [PDF]

, 2007
Background Qualitative methods are increasingly used to study the process of clinical trials and patients understanding of the rationale for trials, randomisation and reasons for taking part or refusing.
Snowdon, Claire, Fairbank, Jeremy, Barker Karen, Fairbank Jeremy, Helen Frost, Fairbank, Jeremy C T, Featherstone Katie, Katie Featherstone, Jeremy Fairbank, Sue Ziebland, Frost, Helen, Snowdon, C, Snowdon Claire, Barker, K, Barker, Karen, MSc, Barker, Karen, Featherstone, Katie, Claire Snowdon, Ziebland, S, Ziebland Sue, Featherstone, K, Ziebland, Sue B, Frost Helen, Ziebland, Sue, Frost, H, Karen Barker   +25 more
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Managing clinical trials. [PDF]

, 2010
Managing clinical trials, of whatever size and complexity, requires efficient trial management. Trials fail because tried and tested systems handed down through apprenticeships have not been documented, evaluated or published to guide new trialists ...
Barbara Farrell, Shakur Haleema, Farrell Barbara, Haleema Shakur, Farrell, B, Kenyon, Sara, Shakur, Haleema, Kenyon, Sara; id_orcid, Shakur, H, Kenyon Sara, Sara Kenyon, Farrell, Barbara   +11 more
core   +2 more sources

Reducing the environmental impact of trials: a comparison of the carbon footprint of the CRASH-1 and CRASH-2 clinical trials. [PDF]

, 2011
BACKGROUND: All sectors of the economy, including the health research sector, must reduce their carbon emissions. The UK National Institute for Health Research has recently prepared guidelines on how to minimize the carbon footprint of research.
Subaiya, Saleena, Hogg, Euan, Ian Roberts, Saleena Subaiya, Roberts Ian, Euan Hogg, Hogg Euan, Subaiya Saleena, Roberts, Ian   +8 more
core   +2 more sources

Contamination in trials of educational interventions [PDF]

, 2007
Objectives: To consider the effects of contamination on the magnitude and statistical significance (or precision) of the estimated effect of an educational intervention, to investigate the mechanisms of contamination, and to consider how contamination ...
Keogh-Brown, M.R., Bachmann, M.O., Ramsay, Craig R, Hewitt, C., Campbell, M.J., Torgerson, D.J., Miles, J.N.V., Howe, A., Shepstone, L., Elbourne, Diana R., Song, F, Harvey, I., Miles, S.   +12 more
core   +3 more sources

Communication about children's clinical trials as observed and experienced: qualitative study of parents and practitioners. [PDF]

, 2011
Recruiting children to clinical trials is perceived to be challenging. To identify ways to optimise recruitment and its conduct, we compared how parents and practitioners described their experiences of recruitment to clinical ...
Shilling, V, Smyth, RL, Bridget Young (128749), Helen Hickey (166297), Paula R. Williamson, Bridget Young, Helen Hickey, Emma Sowden (214406), Valerie Shilling (4460977), Paula R Williamson, Shilling Valerie, Beresford Michael W., Valerie Shilling, Young, B, Rosalind L Smyth, Michael W Beresford, Hickey Helen, Rosalind L Smyth (16234277), Michael W Beresford (9964186), Beresford, MW, Sowden, E, Williamson Paula R., Michael W. Beresford, Emma Sowden, Smyth Rosalind L., Young Bridget, Williamson, PR, Hickey, H, Rosalind L. Smyth, Sowden Emma, Paula R Williamson (11606900)   +30 more
core   +1 more source

The efficacy-effectiveness distinction in trials of alcohol brief intervention. [PDF]

, 2014
Three recent sets of null findings from trials of alcohol brief intervention (BI) have been disappointing to those who wish to see a reduction in alcohol-related harm through the widespread dissemination of BI.
Nick Heather, Heather, Nick
core   +1 more source

The added value of ordinal analysis in clinical trials: an example in traumatic brain injury. [PDF]

, 2011
INTRODUCTION: In clinical trials, ordinal outcome measures are often dichotomized into two categories. In traumatic brain injury (TBI) the 5-point Glasgow outcome scale (GOS) is collapsed into unfavourable versus favourable outcome.
Perel, P, Steyerberg, Ewout W, IMPACT (International Mission on Prognosis and Clinical Trial De, Edwards, P. (Phil), Steyerberg, Ewout, Ewout W Steyerberg, Phil Edwards, Perel, P. (Pablo), Lingsma, Hester F., Murray, G.D. (Gordon), Steyerberg, Ewout W., Roozenbeek, Bob, Lingsma, Hester F, Gordon D Murray, Andrew IR Maas, Edwards, P, Maas, AIR (Arne), Roberts, I. (Ian), CRASH (Corticosteroid Randomisation After Significant Head Injur, Roberts, Ian, Perel, Pablo, Murray, Gordon D, Maas, A.I.R. (Andrew), ?, ?, Ian Roberts, Maas, Andrew Ir, null null, Edwards, Phil, Steyerberg, E.W. (Ewout), Hester F Lingsma, Murray, Gordon D., Pablo Perel, Roozenbeek, B. (Bob), Murray, GD, Bob Roozenbeek, Maas, Andrew I.R., Lingsma, Hester, Roberts, I   +37 more
core   +2 more sources

Pragmatic Problems With Clinical Equipoise

, 2010
It is widely accepted that if one is to follow the ethical tenets of clinical equipoise, phase III controlled clinical trials must be designed pragmatically, to measure effectiveness rather than efficacy.
Kowalski, Charles J
core   +1 more source

Paying clinicians to join clinical trials : a review of guidelines and interview study of trialists [PDF]

, 2009
Background: The motivations of clinicians to participate in clinical trials have been little studied. This project explored the potential role of payment for participation in publicly funded clinical trials in the UK.
Raftery James, Kerr Christine, Hawker, Sheila, Powell John, Powell, John, Hawker Sheila, Raftery, James, Kerr, Christine   +7 more
core   +1 more source