Results 161 to 170 of about 3,627,712 (198)

Design, synthesis, and characterization of novel class of 2-quinolon-3-oxime reactivators for acetylcholinesterase inhibited by organophosphorus compounds

, 2020
The biological effects of organophosphorus (OP) compounds are the results of the irreversible inhibition of acetylcholinesterase (AChE), an important neuro mediator acetylcholine (ACh) splitting enzyme in the human body at the synaptic clefts. Due to the
M. Katagi, S. MamleDesai, Girish Bolakatti, Jennifer Fernandes, M. Sujatha, Prassad Tari   +5 more
semanticscholar   +1 more source

Superior efficacy of HI-6 dimethanesulfonate over pralidoxime methylsulfate against Russian VX poisoning in cynomolgus monkeys (Macaca fascicularis).

Toxicology, 2018
Organophosphorus nerve agents still represent a serious risk to human health. In the French armed forces, the current emergency treatment against OP intoxications is a fully licensed wet-dry dual-chambered autoinjector (Ineurope ®), that contains ...
C. Reymond, N. Jaffré, N. Taudon, M. Menneteau, H. Chaussard, J. Denis, C. Castellarin, F. Dhote, F. Dorandeu   +8 more
semanticscholar   +1 more source

Continuous Flow Synthesis of the Nerve Agent Antidote Pralidoxime (2‐PAM) Iodide

ChemistrySelect
Pralidoxime salts are important medical countermeasures towards different organophosphorus compounds, either nerve agents or pesticides, as they act as acetylcholinesterase reactivators, avoiding health issues and even death that can result from ...
Mauro Gomez, Vinicius C V da Rocha, Letícia S. Chaves, Larissa E. Gotardo, Raquel A. C. Leão, D. A. Kitagawa, Samir F. de A. Cavalcante, Rodrigo O. M. A. de Souza   +7 more
semanticscholar   +1 more source

Tacroximes: novel unique compounds for the recovery of organophosphorus-inhibited acetylcholinesterase.

Future Medicinal Chemistry, 2019
Aim: Organophosphorus compounds are irreversible inhibitors of acetylcholinesterase. Without immediate countermeasure, intoxication leads quickly to death. None of the clinically-used causal antidotes can ensure a good prognosis for any poisoned patient.
L. Górecki, Lucie Junova, T. Kučera, Vendula Hepnarova, L. Prchal, T. Kobrlova, Ľ. Múčková, O. Soukup, J. Korábečný   +8 more
semanticscholar   +1 more source

Integrative oncology: Addressing the global challenges of cancer prevention and treatment

Ca-A Cancer Journal for Clinicians, 2022
Jun J Mao,, Msce, Lorenzo Cohen, Karen M Mustian   +2 more
exaly  

In silico and in vitro evaluation of two novel oximes (K378 and K727) in comparison to K-27 and pralidoxime against paraoxon-ethyl intoxication

Toxicology Mechanisms and Methods, 2018
M. Arshad, M. Q. Fatmi, K. Musílek, A. Hussain, K. Kuča, G. Petroianu, H. Kalasz, S. Nurulain   +7 more
semanticscholar   +1 more source

[Pralidoxime as an antidote in organophosphorus compound poisoning].

Narodno zdravlje, 1974
B, Bosković, V, Vojvodić, I, Pilipović   +2 more
openaire   +1 more source

The value of novel oximes for treatment of poisoning by organophosphorus compounds.

Pharmacology and Therapeutics, 2013
F. Worek, H. Thiermann
semanticscholar   +1 more source

Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime.

Journal of Medicinal Chemistry, 2009
B. Sanson, F. Nachon, J. Colletier, M. Froment, L. Toker, H. Greenblatt, J. Sussman, Y. Ashani, P. Masson, I. Silman, M. Weik   +10 more
semanticscholar   +1 more source

[Acute poisoning by an organophosphoric compound. Effects of pralidoxime on cardiac disorders and serum, erythrocyte and tissue cholinesterase activity].

Anesthesie, analgesie, reanimation, 1966
P, Kissel, M, Duc, A, Duprez, R, Royer
openaire   +1 more source