Results 81 to 90 of about 125,268 (278)
Precision therapies for genetic epilepsies in 2025: Promises and pitfalls
Epilepsia Open, EarlyView.Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang +3 more
wiley +1 more source
Self‐completed patient‐reported outcome measures in adults with epilepsy: A review
Epilepsia Open, EarlyView.Abstract Epilepsy affects 65 million people worldwide, and is a World Health Organization priority disease as highlighted in their 2022–2031 Intersectoral Global Action Plan (IGAP) on Epilepsy and other Neurological Disorders. IGAP's objectives include improving epilepsy treatment and care.
Alison L. Conquest +5 more
wiley +1 more source
Epilepsia Open, EarlyView.Abstract The principle “time is brain” applies to epileptic seizures as well as stroke. Despite existing guidelines, delays in treatment initiation remain common. In 2020, we developed a consensus statement aiming to improve the acute management of emergency seizures and implement a “Seizure Code” (SC) in Madrid, Spain. A multidisciplinary group of 105
Irene García Morales +7 more
wiley +1 more source
Stiripentol use in Dravet syndrome patients in the USA: Results of a real‐world study
Epilepsia Open, EarlyView.Abstract Objective Dravet syndrome (DS) is a severe developmental and epileptic encephalopathy with a high seizure burden and mortality risk. Stiripentol, one of the first DS‐specific therapies, received FDA approval in 2018 but its real‐world use and impact post‐approval in the USA remain insufficiently characterized.
Elaine Wirrell +11 more
wiley +1 more source
Epilepsia Open, EarlyView.Abstract Objective Variants in KCNQ2 encoding the voltage‐gated potassium channel KV7.2 are associated with developmental and epileptic encephalopathy (DEE) of varying severity. This study examined the relationship of KCNQ2 variant dysfunction with the neurodevelopmental phenotype of individuals with KCNQ2‐DEE. Methods A parent‐reported survey gathered
Jessa S. Bidwell +4 more
wiley +1 more source
People‐Centered Approaches That Can Expand the Role of Evaluator
New Directions for Evaluation, EarlyView.ABSTRACT This article tells the collaboratively developed story of a group of seasoned external evaluators who utilized people‐centered approaches as part of their role leading a collective impact initiative, and the lessons they learned along the way. The article is framed for practitioners.
Karen Peterman +8 more
wiley +1 more source
Chapter 12: Black Women Stay Fighting Structural Racism: Other-mothering as Community Praxis
, 2023 Jameta Nicole Barlow
openalex +1 more source
New Directions for Evaluation, EarlyView.ABSTRACT A reflexive stance of program evaluation requires evaluators and researchers to reflect on their role in fostering or interrogating the reproduction of inequities. For these professionals to fully leverage their potential to promote social changes, they must avoid neutral stances by committing to understanding context, challenging deficit ...
María B. Serrano‐Abreu +7 more
wiley +1 more source