Results 61 to 70 of about 30,204 (224)

Reduced efficacy of praziquantel against Schistosoma mansoniis associated with multiple rounds of mass drug administration [PDF]

, 2016
Background: Mass drug administration (MDA) with praziquantel is the cornerstone of schistosomiasis control in sub-Saharan Africa. The effectiveness of this strategy is dependent on the continued high efficacy of praziquantel; however, drug efficacy is ...
Cotton, James A., Crellen, Thomas, Kabatereine, Narcis B., Lamberton, Poppy H.L., Tukahebwa, Edridah M., Walker, Martin, Webster, Joanne P.   +6 more
core   +5 more sources

The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand

Nature Communications, 2017
Schistosomiasis is caused by infection with the flatworm Schistosoma, and praziquantel is the drug of choice for its treatment. Here, Chan and colleagues identify praziquantel as a ligand for the human serotoninergic 5-HT2B G-protein-coupled receptor ...
John D. Chan, Pauline M. Cupit, Gihan S. Gunaratne, John D. McCorvy, Yang Yang, Kristen Stoltz, Thomas R. Webb, Peter I. Dosa, Bryan L. Roth, Ruben Abagyan, Charles Cunningham, Jonathan S. Marchant   +11 more
doaj   +1 more source

Development of a field diagnostic tool for Schistosoma mansoni Praziquantel resistant markers in selected endemic communities [PDF]

Research Ideas and Outcomes
Schistosomiasis is a neglected tropical disease that affects more than 200 million people and 45% of infections have been shown to occur in school-aged children. A large percentage of the disease burden lies in Africa. In 2012, the WHO outlined a roadmap
Maame Ekua Acquah, Frank Aboagye, Yvonne Ashong, Lydia Mosi   +3 more
doaj   +3 more sources

Praziquantel: its use in control of schistosomiasis in sub-Saharan Africa and current research needs [PDF]

, 2009
Treatment with praziquantel (PZQ) has become virtually the sole basis of schistosomiasis control in sub-Saharan Africa and elsewhere, and the drug is reviewed here in the context of the increasing rate that it is being used for this purpose. Attention is
A. MBAYE, Alonso, Baard, Barakat, Botros, Botros, Cioli, D. CIOLI, D. ENGELS, G. COLES, Keiser, L. A. TCHUEM TCHUENTÉ, L. PICA-MATTOCCIA, M. J. DOENHOFF, Mwanakasale, N'Goran, P. HAGAN, Pica-Mattoccia, S. BOTROS, Stohler, Utzinger, V. SOUTHGATE, Van Wyk   +22 more
core   +2 more sources

Praziquantel is an effective drug for the treatment of Schistosoma Mansoni infection among school-aged children in Northwest Ethiopia

Tropical Medicine and Health, 2020
The appropriate drug for the treatment of schistosomiasis is praziquantel. However, low cure rate and existence of drug resistance both in vivo and in vitro were reported in different endemic areas.
Addisu Tesfie, Gebeyaw Getnet, Aberham Abere, G. Yihenew, Yerega Belete, Melkayehu Kassa, A. Gize   +6 more
semanticscholar   +1 more source

Preparation and In Vitro/In Vivo Evaluation of Orally Disintegrating/Modified-Release Praziquantel Tablets

Pharmaceutics, 2021
This study was designed to develop orally disintegrating/sustained-release praziquantel (PZQ) tablets using the hot-melt extrusion (HME) technique and direct compression, and subsequently evaluate their release in in vitro and in vivo pharmacokinetics ...
Xuemei Wen, Zhaoyou Deng, Yangfeng Xu, Guoqing Yan, Xin Deng, Liqin Wu, Qiuling Liang, Fang Fang, Xin Feng, Meiling Yu, Jiakang He   +10 more
doaj   +1 more source

Looking for Greener Pastures: In Vitro Screening of Phytogenics for the Control of Sparicotyle chrysophrii in Gilthead Sea Bream

Journal of Fish Diseases, EarlyView.
ABSTRACT The gill parasite Sparicotyle chrysophrii poses a significant threat to gilthead sea bream (Sparus aurata) aquaculture in the Mediterranean, causing considerable mortality and economic losses. As traditional chemotherapeutic treatments, like formalin, face growing regulatory restrictions, there is an urgent need for alternative control ...
Teresa Pirollo, Ana León, Monica Caffara, Alice Caneschi, Itziar Estensoro, Jinni Gu, Maurizio Scozzoli, Ariadna Sitjà‐Bobadilla, Oswaldo Palenzuela   +8 more
wiley   +1 more source

The anthelmintic drug praziquantel activates a schistosome transient receptor potential channel

Journal of Biological Chemistry, 2019
The anthelmintic drug praziquantel (PZQ) is used to treat schistosomiasis, a neglected tropical disease that affects over 200 million people worldwide.
Sang-Kyu Park, Gihan S. Gunaratne, E. Chulkov, Francie Moehring, P. McCusker, P. Dosa, John D. Chan, C. Stucky, J. Marchant   +8 more
semanticscholar   +1 more source

The immune-dependence of chemotherapy in experimental schistosomiasis

Memorias do Instituto Oswaldo Cruz, 1989
Experimental evidence indicates that immune effector mechanisms can enhance the activity of schistosomicidal drugs. Praziquantel, oxamniquine, hycanthone and antimony were less effective against Schistosoma mansoni infections in mice immunosuppressed by ...
M. J. Doenhoff
doaj   +1 more source

Bath Treatments With Emamectin Benzoate Control Dactylogyrideans Infecting Colossoma macropomum Gills Without Altering Physiology of This Host Fish

Journal of Fish Diseases, EarlyView.
ABSTRACT Intensification of fish aquaculture worldwide has led to severe problems of diseases caused by parasitic dactylogyrideans. In this study, the anti‐dactylogyridean efficacy of treating Colossoma macropomum with baths of emamectin benzoate (EMB) was investigated for the first time, along with the effects of this treatment on the haematology and ...
Raimundo Rosemiro de Jesus Baia, Marcela Nunes Videira, Amanda Mendes Pacheco, Eliane Tie Oba Yoshioka, Marcos Tavares‐Dias   +4 more
wiley   +1 more source