Results 61 to 70 of about 29,845 (261)

Structure‐based discovery of thiamine uptake inhibitors

British Journal of Pharmacology, Volume 182, Issue 22, Page 5611-5626, November 2025.
Background and Purpose Thiamine (vitamin B1) is an essential coenzyme and catalyses various reactions in central metabolic pathways. Since mammals have lost the ability to synthesise thiamine de novo, this micronutrient has to be imported via the high affinity solute carriers SLC19A2 and A3 across the plasma membrane.
Florian Gabriel, Björn Windshügel, Christian Löw   +2 more
wiley   +1 more source

Efficacy of Essential Oils of Thymus vulgaris and Origanum vulgare on Echinococcus granulosus [PDF]

, 2014
The aim of the present work was to determine the in vitro effect of T. vulgaris and O. vulgare essential oils against E. granulosus protoscoleces and cysts. Essential oils were added to the medium resulting in thymol final concentrations of 10 μg/mL. The
Denegri, Guillermo Maria, Eguaras, Martin Javier, Elissondo, María Celina, Gende, Liesel Brenda, Maggiore, Marina Alejandra, Pensel, Patricia Eugenia   +5 more
core   +1 more source

Exploring the 3D Bioprinting Landscape in the Delivery of Active Pharmaceutical Compounds for Therapeutic and Regenerative Medicine Applications

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 113, Issue 10, October 2025.
Three‐dimensional (3D) bioprinting is revolutionizing drug delivery and regenerative medicine by enabling personalized, controlled‐release therapeutic systems. This review explores advancements in biocompatible bioinks, nanomedicines, and 3D‐printed drug delivery constructs, including scaffolds, implants, and bioactive hydrogels.
Khonzisizwe Somandi, Yahya E. Choonara
wiley   +1 more source

Ground Calcium Carbonate as a Low Cost and Biosafety Excipient for Solubility and Dissolution Improvement of Praziquantel

Pharmaceutics, 2019
Calcium carbonate is an abundant mineral with several advantages to be a successful carrier to improve oral bioavailability of poorly water-soluble drugs, such as praziquantel.
Ana Borrego-Sánchez, Rita Sánchez-Espejo, Beatrice Albertini, Nadia Passerini, Pilar Cerezo, César Viseras, C. Ignacio Sainz-Díaz   +6 more
doaj   +1 more source

Efficacy and safety of praziquantel and dihydroartemisinin piperaquine combination for treatment and control of intestinal schistosomiasis: A randomized, non-inferiority clinical trial.

PLoS Neglected Tropical Diseases, 2020
BackgroundDespite the reported success in reducing morbidity, praziquantel alone is insufficient for the control and elimination of schistosomiasis, partly due to its poor efficacy against the juvenile worms. Artemisinin derivatives are effective against
Rajabu Hussein Mnkugwe, Omary Minzi, Safari Kinung'hi, Appolinary Kamuhabwa, Eleni Aklillu   +4 more
doaj   +1 more source

Tunable Polymeric Mixed Micellar Nanoassemblies of Lutrol F127/Gelucire 44/14 for Oral Delivery of Praziquantel: A Promising Nanovector against Hymenolepis nana in Experimentally-Infected Rats

Pharmaceutics, 2022
Hymenolepiasis represents a parasitic infection of common prevalence in pediatrics with intimidating impacts, particularly amongst immunocompromised patients.
Waleed M. Arafa, Mohammed H. Elkomy, Heba M. Aboud, Mona Ibrahim Ali, Samah S. Abdel Gawad, Shawky M. Aboelhadid, Emad A. Mahdi, Izzeddin Alsalahat, Heba Abdel-Tawab   +8 more
doaj   +1 more source

One Health – an Ecological and Evolutionary Framework for tackling Neglected Zoonotic Diseases [PDF]

, 2015
Understanding the complex population biology and transmission ecology of multihost parasites has been declared as one of the major challenges of biomedical sciences for the 21st century and the Neglected Zoonotic Diseases (NZDs) are perhaps the most ...
Adamo, Akopyants, Anderson, Antia, Azevedo, Berry, Betson, Biswas, Boatin, Boissier, Chargui, Civetello, Cleaveland, Combes, Consortium* THG, Crichton, Criscione, Cutillas, Delgado, Detwiler, Dobson, Doby, Dunams-Morel, Eberhard, Fan, Faye, Fenton, Fenton, Fraga de Azevedo, Funk, Garba, Gaunt, Gelanew, Genis, Gibbs, Gibson, Gouvras, Gretillat, Grigg, Gupta, Hahn, Hahn, Hanelt, Hargrove, Haydon, Hotez, Hotez, Huyse, Huyse, Inpankaew, Johnson, Jolles, Kaushik, Kaushik, Keesing, Kelly, Kilpatrick, King, Klepac, Koukounari, Lamberton, Laval, Le, Leger, Lembo, Liang, Liese, Lloyd-Smith, Lu, Lu, Lu, Lu, Lustigman, Machado, Maia, Mathews, Mavarez, Messenger, Messenger, Miles, Molyneux, Moné, Muhanguzi, Muller-Graf, Mupfasoni, Norton, Pardo-Diaz, Parrish, Pedersen, Perez-Quintero, Ramiro, Randolph, Ravel, Robinson, Rogers, Rollinson, Rudge, Rudge, Rudge, Salkeld, Saroufim, Silva Oliveira, Smith, Steinauer, Strauss, Streicker, Streicker, Sturm, Taylor, Theron, Theron, Tomley, UNDP, Viana, Volf, Wang, Webby, Webster, Webster, Webster, Webster, Webster, Webster, Welburn, Welburn, Whitlock, WHO, Wood, Woolhouse, Woolhouse, Woolhouse, Woolhouse, Woolhouse, Yamane, Yamane, Zhou   +135 more
core   +4 more sources

Paragonimiasis Diagnosed Through Detection of Parasitic Ova in Pleural Effusion: A Clinical Case Report

Respirology Case Reports, Volume 13, Issue 10, October 2025.
We report a rare case of paragonimiasis initially presenting with trauma. Initial imaging and laboratory findings were predominantly indicative of trauma and nonspecific inflammatory responses, which obscured the clues of parasitic infection. The definitive diagnosis was achieved through comprehensive epidemiological history collection and parasitic ...
Man Luo, Yang Liu, Xianyao Yang, Mei Liu, Chao Yu   +4 more
wiley   +1 more source

Revisiting the Dissolution of Praziquantel in Biorelevant Media and the Impact of Digestion of Milk on Drug Dissolution

Pharmaceutics, 2022
Praziquantel is a poorly water-soluble drug used to treat parasitic infections. Previous studies have suggested that its rate and extent of dissolution in milk and biorelevant media are slow and limited compared to dissolution in the pharmacopoeial ...
Thomas Eason, Gisela Ramirez, Andrew J. Clulow, Malinda Salim, Ben J. Boyd   +4 more
doaj   +1 more source

Tratamento da neurocisticercose com praziquantel [PDF]

Arquivos de Neuro-Psiquiatria, 1990
27 pacientes com neurocisticercose foram tratados com praziquantel, utilizado em doses progressivamente crescentes até alcançar 50 mg/kg/dia, por período de 21 dias, associado a dexametasona. Os doentes foram avaliados clínica e laboratorialmente durante o tratamento e, aqueles que completaram um ano de evolução, repetiram os testes imunofluorescência ...
Paulo Andrade de Mello, Lucy Gomes Vianna, Julia Maria Costa, H. A. O. Souza, H. A. O. Souza, Vanize Macêdo   +5 more
openaire   +5 more sources