Results 61 to 70 of about 37,525 (284)

Praziquantel sensitivity of Kenyan Schistosoma mansoni isolates and the generation of a laboratory strain with reduced susceptibility to the drug

International Journal for Parasitology: Drugs and Drug Resistance, 2014
Schistosomiasis is a neglected tropical disease caused by blood-dwelling flukes of the genus Schistosoma. While the disease may affect as many as 249 million people, treatment largely relies on a single drug, praziquantel.
Ibrahim N. Mwangi, Melissa C. Sanchez, Gerald M. Mkoji, Lelo E. Agola, Steven M. Runo, Pauline M. Cupit, Charles Cunningham   +6 more
doaj   +1 more source

Praziquantel ameliorates CCl4‐induced liver fibrosis in mice by inhibiting TGF‐β/Smad signalling via up‐regulating Smad7 in hepatic stellate cells

British Journal of Pharmacology, 2019
Praziquantel is a schistosomicide, which has been used for more than 30 years due to its efficiency, safety, and mild side effects. Previous studies showed that prolonged treatment with praziquantel suppressed the development of liver fibrosis in mice ...
Jin-feng Liu, Delong Kong, J. Qiu, Yanci Xie, Z. Lu, Chun-lei Zhou, Xin-jian Liu, Rong Zhang, Yong Wang   +8 more
semanticscholar   +1 more source

Does mass drug administration for the integrated treatment of neglected tropical diseases really work? Assessing evidence for the control of schistosomiasis and soil-transmitted helminths in Uganda [PDF]

, 2011
This paper was one of four papers commissioned to review the role of social sciences in NTD control by TDR, the Special Programme for Research and Training on Tropical Diseases, which is executed by WHO and co-sponsored by UNICEF, UNDP, the World Bank ...
A Dansio-Appiah, A Fenwick, A Fenwick, B Gryseels, B Gryseels, CJ Standley, D Engels, D Yu, DH Molyneux, DH Molyneux, EP Renne, FM Fleming, G Yamey, I Harper, J Hastings, J Utzinger, JH Kolaczinski, L Manderson, M Leach, M Parker, M Parker, M Parker, M Parker, M Yahya, MA Brady, Melissa Parker, MN Katabarawa, MN Katabarwa, N Rees, NB Kabatereine, NB Kabatereine, NB Kabatereine, PJ Hotez, PJ Hotez, PJ Lammie, RGN Lubanga, S Brooker, S Knopp, T Allen, T Allen, T Allen, T Allen, T Allen, T Allen, Tim Allen, TL-A Tchuente, U Amazigo, World Health Organization, Y Coulibaly   +48 more
core   +4 more sources

Development of a field diagnostic tool for Schistosoma mansoni Praziquantel resistant markers in selected endemic communities [PDF]

Research Ideas and Outcomes
Schistosomiasis is a neglected tropical disease that affects more than 200 million people and 45% of infections have been shown to occur in school-aged children. A large percentage of the disease burden lies in Africa. In 2012, the WHO outlined a roadmap
Maame Ekua Acquah, Frank Aboagye, Yvonne Ashong, Lydia Mosi   +3 more
doaj   +3 more sources

Immunomics-Guided Antigen Discovery for Praziquantel-Induced Vaccination in Urogenital Human Schistosomiasis

Frontiers in Immunology, 2021
Despite the enormous morbidity attributed to schistosomiasis, there is still no vaccine to combat the disease for the hundreds of millions of infected people.
Mark S. Pearson, Bemnet A. Tedla, Luke Becker, Rie Nakajima, Al Jasinskas, Takafira Mduluza, Takafira Mduluza, Francisca Mutapi, Francisca Mutapi, Claude Oeuvray, Beatrice Greco, Javier Sotillo, Javier Sotillo, Philip L. Felgner, Alex Loukas   +14 more
doaj   +1 more source

The effect of anthelmintic treatment during pregnancy on HIV plasma viral load: results from a randomized, double-blind, placebo-controlled trial in Uganda. [PDF]

, 2012
BACKGROUND: To investigate the effect of helminth infections and their treatment during pregnancy on HIV load, we conducted a 2 × 2 factorial randomized controlled trial of albendazole versus placebo and praziquantel versus placebo in pregnant women in ...
Elliott, Alison M, Kaleebu, Pontiano, Kizito, Dennison, Kyosiimire-Lugemwa, Jacqueline, Lule, Swaib, Muhangi, Lawrence, Muwanga, Moses, Nkurunziza, Peter, Webb, Emily L   +8 more
core   +1 more source

Advances in Mechanochemical Methods for One‐Pot Multistep Organic Synthesis

Chemistry – A European Journal, EarlyView.
This review highlights recent advances in mechanochemical methods for multistep organic synthesis, focusing on sequential one‐pot approaches performed by grinding or ball milling. The presented transformations are discussed in terms of efficiency, applicability, and sustainability, assessing both the challenges and potential of solvent‐free one‐pot ...
Nina Biedermann, Michael Schnürch
wiley   +1 more source

The immune-dependence of chemotherapy in experimental schistosomiasis

Memorias do Instituto Oswaldo Cruz, 1989
Experimental evidence indicates that immune effector mechanisms can enhance the activity of schistosomicidal drugs. Praziquantel, oxamniquine, hycanthone and antimony were less effective against Schistosoma mansoni infections in mice immunosuppressed by ...
M. J. Doenhoff
doaj   +1 more source

Human liver flukes [PDF]

, 2017
Liver fluke infections occur in people worldwide. In some low-income regions, a combination of ecological, agricultural, and culinary factors leads to a very high prevalence of infection but, in higher-income regions, infections are uncommon.
Harrington, David, Lamberton, Poppy H.L., McGregor, Alastair   +2 more
core   +1 more source

Steroid‐responsive generalised sterile necrotising pyogranulomatous lymphadenitis in a cat

Journal of Small Animal Practice, EarlyView.
A 1.5‐year‐old neutered male cat was presented with fever, inappetence, lethargy and marked generalised lymphadenopathy of 4 days duration. Excisional biopsy of peripheral lymph nodes revealed necrotising pyogranulomatous lymphadenitis. Extensive investigation failed to identify an underlying infectious [bacterial (Bartonella, Mycobacteria, Mycoplasma,
L. Lecot, E. Ramery, M. Hugonnard, A. Tortereau, É. Krafft   +4 more
wiley   +1 more source