Results 41 to 50 of about 19,502 (213)

Efficacy of praziquantel against Schistosoma mekongi and Opisthorchis viverrini: a randomized, single-blinded dose-comparison trial [PDF]

, 2012
BACKGROUND: Schistosomiasis and opisthorchiasis are of public health importance in Southeast Asia. Praziquantel (PZQ) is the drug of choice for morbidity control but few dose comparisons have been made.
Youthanavanh Vonghachack (148917), Khampheng Phongluxa, Phonepasong Ayé Soukhathammavong (148913), Jennifer Keiser, Utzinger, Jürg, Tanner, M., Odermatt Peter, Leonore Lovis (148903), Utzinger Jürg, Youthanavanh Vonghachack, Peter Odermatt, Hatz, Christoph, Vounatsou Penelope, Vounatsou, P., Phonepasong Ayé Soukhathammavong, Jennifer Keiser (39606), Phongluxa, Khampheng, Sripa, Banchob, Soukhathammavong, Phonepasong Ayé, Ayé Soukhathammavong Phonepasong, Soukhathammavong, P. A., Vonghachack, Youthanavanh, Utzinger, J., Jürg Utzinger (39609), Tanner Marcel, Tippi K Mak, Christoph Hatz (35423), Penelope Vounatsou (49253), Phongluxa Khampheng, Akkhavong, Kongsap, Mak, T. K., Akkhavong Kongsap, Kongsap Akkhavong (148931), Tippi K. Mak (148907), Marcel Tanner (33894), Penelope Vounatsou, Hatz, C., Marcel Tanner, Mak Tippi K., Lovis, L., Mak, Tippi K, Jürg Utzinger, Kongsap Akkhavong, Leonore Lovis, Tanner, Marcel, Vonghachack Youthanavanh, Keiser Jennifer, Odermatt, P., Keiser, J., Odermatt, Peter, Akkhavong, K., Peter Odermatt (148926), Keiser, Jennifer, Hatz Christoph, Lovis, Leonore, Vonghachack, Y., Khampheng Phongluxa (148910), Lovis Leonore, Vounatsou, Penelope, Christoph Hatz, Phongluxa, K., Ayé Soukhathammavong P, Vonghachack Y, Hatz C, Vounatsou P, Tanner M, Akkhavong K, Keiser J, Utzinger J, Odermatt P, Mak TK, Lovis L, Phongluxa K   +72 more
core   +2 more sources

Praziquantel decreases fecundity in Schistosoma mansoni adult worms that survive treatment: evidence from a laboratory life-history trade-offs selection study

Infectious Diseases of Poverty, 2017
Background Mass drug administration of praziquantel is the World Health Organization’s endorsed control strategy for schistosomiasis. A decade of annual treatments across sub-Saharan Africa has resulted in significant reductions of infection prevalence ...
Poppy H.L. Lamberton, Christina L. Faust, Joanne P. Webster   +2 more
doaj   +1 more source

Orally active antischistosomal early leads identified from the open access malaria box. [PDF]

, 2014
BACKGROUND: Worldwide hundreds of millions of schistosomiasis patients rely on treatment with a single drug, praziquantel. Therapeutic limitations and the threat of praziquantel resistance underline the need to discover and develop next generation drugs.
Wells, Timothy N. C., Bickle, Quentin D, Bickle, Quentin D., Mansour Nuha R., Jennifer Keiser, Wells, Timothy NC, Bickle, Quentin, Bickle Quentin D., Nuha R. Mansour (146895), Geary, Timothy G., Panic, Gordana, Vargas Mireille, Gordana Panic, Katrin Ingram-Sieber (507683), Cowan, Noemi, Mansour, Nuha, Quentin D. Bickle (146947), Jennifer Keiser (39606), Noemi Cowan (507684), Quentin D. Bickle, Mansour, Nuha R., Katrin Ingram-Sieber, Spangenberg, Thomas, Mireille Vargas, Thomas Spangenberg (422569), Cowan Noemi, Keiser Jennifer, Mireille Vargas (392661), Ingram-Sieber, Katrin, Timothy N C Wells, Quentin D Bickle, Noemi Cowan, Panic Gordana, Timothy N. C. Wells (422572), Ingram-Sieber Katrin, Wells Timothy N. C., Nuha R Mansour, Timothy N. C. Wells, Gordana Panic (507685), Mansour, Nuha R, Keiser, Jennifer, Thomas Spangenberg, Nuha R. Mansour, Spangenberg Thomas, Vargas, Mireille, Panic G, Mansour NR, Spangenberg T, Ingram-Sieber K, Keiser J, Bickle QD, Vargas M, Cowan N, Wells TN   +53 more
core   +1 more source

Safety of topical administration of fluralaner plus moxidectin concurrently with praziquantel in cats

Parasites & Vectors, 2018
Background Fluralaner provides efficacy against feline ectoparasites following topical administration. Moxidectin is routinely used to treat gastrointestinal nematode infections and prevent heartworm disease caused by Dirofilaria immitis. Praziquantel is
Feli M. Walther, Petr Fisara, Rainer K. A. Roepke   +2 more
doaj   +1 more source

Transcriptional responses of in vivo praziquantel exposure in schistosomes identifies a functional role for calcium signalling pathway member CamKII. [PDF]

PLoS Pathogens, 2013
Treatment for clinical schistosomiasis has relied centrally on the broad spectrum anthelmintic praziquantel; however, there is limited information on its mode of action or the molecular response of the parasite.
Hong You, Donald P McManus, Wei Hu, Michael J Smout, Paul J Brindley, Geoffrey N Gobert   +5 more
doaj   +1 more source

Praziquantel (Droncit) is effective against diplostomosis of grasscarp Ctenopharyngodon idella and silver carp Hypophthalmichthys molitrix [PDF]

, 1991
In laboratory experiments praziquantel (Droncit) effectively destroyed metacercariae of Diplostomum spathaceum (s. l.) parasitizing the eye lens of grasscarp Ctenopharyngodon idella and silver carp Hypophthalmichthys molitrix.
Molnár, Kálmán, Székely, Csaba
core   +1 more source

The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand

Nature Communications, 2017
Schistosomiasis is caused by infection with the flatworm Schistosoma, and praziquantel is the drug of choice for its treatment. Here, Chan and colleagues identify praziquantel as a ligand for the human serotoninergic 5-HT2B G-protein-coupled receptor ...
John D. Chan, Pauline M. Cupit, Gihan S. Gunaratne, John D. McCorvy, Yang Yang, Kristen Stoltz, Thomas R. Webb, Peter I. Dosa, Bryan L. Roth, Ruben Abagyan, Charles Cunningham, Jonathan S. Marchant   +11 more
doaj   +1 more source

Praziquantel sensitivity of Kenyan Schistosoma mansoni isolates and the generation of a laboratory strain with reduced susceptibility to the drug

International Journal for Parasitology: Drugs and Drug Resistance, 2014
Schistosomiasis is a neglected tropical disease caused by blood-dwelling flukes of the genus Schistosoma. While the disease may affect as many as 249 million people, treatment largely relies on a single drug, praziquantel.
Ibrahim N. Mwangi, Melissa C. Sanchez, Gerald M. Mkoji, Lelo E. Agola, Steven M. Runo, Pauline M. Cupit, Charles Cunningham   +6 more
doaj   +1 more source

Praziquantel analogs with activity against juvenile Schistosoma mansoni.

, 2010
Six amide and four urea derivatives of praziquantel were synthesized and tested for antischistosomal activity against juvenile and adults stages of Schistosoma mansoni in infected mice. Only one of these had significant activity against adult worms, but,
Vennerstrom, Jonathan L, Bickle, Quentin, Bickle, Q., Chollet, Jacques, Keiser, J., Mansour, N. R., Alnouti, Yazen, Huang, Jiangeng, Vennerstrom, J. L., Mansour, Nuha R, Dong, Y., Keiser, Jennifer, Vargas, M., Dong, Yuxiang, Alnouti, Y., Vargas, Mireille, Chollet, J., Huang, J., Jennifer Keiser, Jonathan L. Vennerstrom, Yazen Alnouti, Mireille Vargas, Jacques Chollet, Nuha R. Mansour, Jiangeng Huang, Yuxiang Dong, Quentin Bickle   +26 more
core   +1 more source

Uptake of mass drug administration programme for schistosomiasis control in Koome Islands, Central Uganda. [PDF]

, 2015
INTRODUCTION: Schistosomiasis is one of the neglected tropical diseases targeted for elimination in Uganda through the Mass Drug Administration (MDA) programme.
Nuwaha, Fred, Bagonza, James, Fred Nuwaha, James Bagonza (716006), Tuhebwe Doreen, Yeka, Adoke, Doreen Tuhebwe, Yeka Adoke, Elliott Alison M., Elizabeth Ekirapa Kiracho (716007), Kiracho Elizabeth Ekirapa, Bagonza James, Kiracho, Elizabeth Ekirapa, Doreen Tuhebwe (716005), Nuwaha Fred, Alison M Elliott, Alison M. Elliott (114054), Adoke Yeka, Elliott, Alison M, Elizabeth Ekirapa Kiracho, Adoke Yeka (18017), Tuhebwe, Doreen, James Bagonza, Fred Nuwaha (169425)   +23 more
core   +1 more source