Results 41 to 50 of about 23,001 (237)

Praziquantel in clonorchiasis and opisthorchiasis [PDF]

, 1981
A single stool examination revealed pathogenic intestinal parasites in 462 (58%) of 796 vietnamese and cambodian refugees. 56 (7.0%) were infected with Clonorchis sinensis and/or Opisthorchis viverrini. These patients received Praziquantel in a dosage of
Lang, W., Nothdurft, H. D., Prüfer, L., Löscher, Thomas, Sonnenburg, F. von   +4 more
core   +1 more source

Safety of topical administration of fluralaner plus moxidectin concurrently with praziquantel in cats

Parasites & Vectors, 2018
Background Fluralaner provides efficacy against feline ectoparasites following topical administration. Moxidectin is routinely used to treat gastrointestinal nematode infections and prevent heartworm disease caused by Dirofilaria immitis. Praziquantel is
Feli M. Walther, Petr Fisara, Rainer K. A. Roepke   +2 more
doaj   +1 more source

Enhancing control of schistosomiasis in Niger : assessing morbidity in preschool-aged children, praziquantel treatment efficacy and cost implication for control [PDF]

, 2013
Background: Schistosomiasis, accounted among the neglected tropical diseases (NTDs), represents a major public health problem, particularly in Africa, where more than 95% of all the cases of the world are currently concentrated.
Garba, Amadou
core   +1 more source

Nitazoxanide Exhibits Schistosomicidal Activity Against Schistosomula and Adult Schistosoma mansoni and Influences Praziquantel-Associated Outcomes. [PDF]

Acta Parasitol
Da Costa CJ, Gama JEM, Silva AJM, Saraiva KLA, Peixoto CA, de Araújo RE, Filho CALM, Albuquerque GHA, Moura DMN, De Oliveira SA.   +9 more
europepmc   +3 more sources

Sustaining control of Schistosomiasis mansoni in western Côte d'Ivoire : results from a SCORE study, one year after initial praziquantel administration [PDF]

, 2016
The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) has launched several large-scale trials to determine the best strategies for gaining and sustaining control of schistosomiasis and transitioning toward elimination.
Eveline Hürlimann, Mamadou Ouattara (128981), Utzinger, Jürg, Coulibaly, Jean T., Aboulaye Meïté, Meïté, Aboulaye, Jean T Coulibaly, Yapi, Ahoua, Stefanie Knopp, Nicaise A. N’Guessan (846783), Eliézer K. N’Goran (417750), Assaré, Rufin K., Jean T. Coulibaly (108845), N'Guessan, Nicaise A., Jürg Utzinger, Patrick K. Yao (846782), Yves-Nathan T. Tian-Bi (846781), Nicaise A N'Guessan, Jürg Utzinger (39609), Mamadou Ouattara, Yves-Nathan T Tian-Bi, Ahoua Yapi, Stefanie Knopp (108848), Rufin K. Assaré (846780), Eveline Hürlimann (217729), Aboulaye Meïté (846784), Eliézer K N'Goran, Ouattara, Mamadou, Rufin K Assaré, Patrick K Yao, N'Goran, Eliézer K., Hürlimann, Eveline, Knopp, Stefanie, Ahoua Yapi (51490), Yao, Patrick K., Tian-Bi, Yves-Nathan T.   +35 more
core   +2 more sources

The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand

Nature Communications, 2017
Schistosomiasis is caused by infection with the flatworm Schistosoma, and praziquantel is the drug of choice for its treatment. Here, Chan and colleagues identify praziquantel as a ligand for the human serotoninergic 5-HT2B G-protein-coupled receptor ...
John D. Chan, Pauline M. Cupit, Gihan S. Gunaratne, John D. McCorvy, Yang Yang, Kristen Stoltz, Thomas R. Webb, Peter I. Dosa, Bryan L. Roth, Ruben Abagyan, Charles Cunningham, Jonathan S. Marchant   +11 more
doaj   +1 more source

Praziquantel sensitivity of Kenyan Schistosoma mansoni isolates and the generation of a laboratory strain with reduced susceptibility to the drug

International Journal for Parasitology: Drugs and Drug Resistance, 2014
Schistosomiasis is a neglected tropical disease caused by blood-dwelling flukes of the genus Schistosoma. While the disease may affect as many as 249 million people, treatment largely relies on a single drug, praziquantel.
Ibrahim N. Mwangi, Melissa C. Sanchez, Gerald M. Mkoji, Lelo E. Agola, Steven M. Runo, Pauline M. Cupit, Charles Cunningham   +6 more
doaj   +1 more source

Whole organism high-content screening by label-free, image-based Bayesian classification for parasitic diseases. [PDF]

, 2012
Sole reliance on one drug, Praziquantel, for treatment and control of schistosomiasis raises concerns about development of widespread resistance, prompting renewed interest in the discovery of new anthelmintics.
Bickle, Quentin D, Bickle, Quentin D., Mansour Nuha R., Gilbert, Ian H, Alex E Benn, Bickle Quentin D., Ian H Gilbert, Nuha R. Mansour (146895), Andrew L. Hopkins (146939), Ivana Mikic (146920), Benn Alex E., Guidi Alessandra, Leo S. Bleicher (146907), Hopkins, Andrew L, Gilbert, Ian H., Bleicher Leo S., Hopkins Andrew L., Guidi, Alessandra, Benn, Alex E., Ivana Mikic, Quentin D. Bickle (146947), Alex E. Benn (146913), Irene Hallyburton (146900), Ian H. Gilbert (146934), Bleicher, Leo S, Alessandra Guidi (146927), Mansour, Nuha R., Paveley, Ross A., Alessandra Guidi, Bleicher, Leo S., Ross A Paveley, Irene Hallyburton, Quentin D Bickle, Hallyburton, Irene, Paveley Ross A., Paveley, Ross A, Mikic Ivana, Nuha R Mansour, Ross A. Paveley (146889), Mansour, Nuha R, Leo S Bleicher, Mikic, Ivana, Hopkins, Andrew L., Andrew L Hopkins, Hallyburton Irene, Gilbert Ian H., Benn, Alex E   +46 more
core   +2 more sources

Orally active antischistosomal early leads identified from the open access malaria box. [PDF]

, 2014
BACKGROUND: Worldwide hundreds of millions of schistosomiasis patients rely on treatment with a single drug, praziquantel. Therapeutic limitations and the threat of praziquantel resistance underline the need to discover and develop next generation drugs.
Wells, Timothy N. C., Bickle, Quentin D, Bickle, Quentin D., Mansour Nuha R., Jennifer Keiser, Wells, Timothy NC, Bickle, Quentin, Bickle Quentin D., Nuha R. Mansour (146895), Geary, Timothy G., Panic, Gordana, Vargas Mireille, Gordana Panic, Katrin Ingram-Sieber (507683), Cowan, Noemi, Mansour, Nuha, Quentin D. Bickle (146947), Jennifer Keiser (39606), Noemi Cowan (507684), Quentin D. Bickle, Mansour, Nuha R., Katrin Ingram-Sieber, Spangenberg, Thomas, Mireille Vargas, Thomas Spangenberg (422569), Cowan Noemi, Keiser Jennifer, Mireille Vargas (392661), Ingram-Sieber, Katrin, Timothy N C Wells, Quentin D Bickle, Noemi Cowan, Panic Gordana, Timothy N. C. Wells (422572), Ingram-Sieber Katrin, Wells Timothy N. C., Nuha R Mansour, Timothy N. C. Wells, Gordana Panic (507685), Mansour, Nuha R, Keiser, Jennifer, Thomas Spangenberg, Nuha R. Mansour, Spangenberg Thomas, Vargas, Mireille   +44 more
core   +1 more source

Comparison of microscopy and Alamar blue reduction in a larval based assay for schistosome drug screening. [PDF]

, 2010
BACKGROUND: In view of the current widespread use of and reliance on a single schistosomicide, praziquantel, there is a pressing need to discover and develop alternative drugs for schistosomiasis.
Bickle, Quentin D, Mansour Nuha R., Nuha R Mansour, Mansour, Nuha R, Bickle Quentin D., Nuha R. Mansour, Quentin D Bickle, Quentin D. Bickle   +7 more
core   +1 more source