Results 41 to 50 of about 17,340 (213)

Preparation and In Vitro/In Vivo Evaluation of Orally Disintegrating/Modified-Release Praziquantel Tablets

Pharmaceutics, 2021
This study was designed to develop orally disintegrating/sustained-release praziquantel (PZQ) tablets using the hot-melt extrusion (HME) technique and direct compression, and subsequently evaluate their release in in vitro and in vivo pharmacokinetics ...
Xuemei Wen, Zhaoyou Deng, Yangfeng Xu, Guoqing Yan, Xin Deng, Liqin Wu, Qiuling Liang, Fang Fang, Xin Feng, Meiling Yu, Jiakang He   +10 more
doaj   +1 more source

Orally active antischistosomal early leads identified from the open access malaria box. [PDF]

, 2014
BACKGROUND: Worldwide hundreds of millions of schistosomiasis patients rely on treatment with a single drug, praziquantel. Therapeutic limitations and the threat of praziquantel resistance underline the need to discover and develop next generation drugs.
Wells, Timothy N. C., Bickle, Quentin D, Bickle, Quentin D., Mansour Nuha R., Jennifer Keiser, Wells, Timothy NC, Bickle, Quentin, Bickle Quentin D., Nuha R. Mansour (146895), Geary, Timothy G., Panic, Gordana, Vargas Mireille, Gordana Panic, Katrin Ingram-Sieber (507683), Cowan, Noemi, Mansour, Nuha, Quentin D. Bickle (146947), Jennifer Keiser (39606), Noemi Cowan (507684), Quentin D. Bickle, Mansour, Nuha R., Katrin Ingram-Sieber, Spangenberg, Thomas, Mireille Vargas, Thomas Spangenberg (422569), Cowan Noemi, Keiser Jennifer, Mireille Vargas (392661), Ingram-Sieber, Katrin, Timothy N C Wells, Quentin D Bickle, Noemi Cowan, Panic Gordana, Timothy N. C. Wells (422572), Ingram-Sieber Katrin, Wells Timothy N. C., Nuha R Mansour, Timothy N. C. Wells, Gordana Panic (507685), Mansour, Nuha R, Keiser, Jennifer, Thomas Spangenberg, Nuha R. Mansour, Spangenberg Thomas, Vargas, Mireille   +44 more
core   +1 more source

Praziquantel sensitivity of Kenyan Schistosoma mansoni isolates and the generation of a laboratory strain with reduced susceptibility to the drug

International Journal for Parasitology: Drugs and Drug Resistance, 2014
Schistosomiasis is a neglected tropical disease caused by blood-dwelling flukes of the genus Schistosoma. While the disease may affect as many as 249 million people, treatment largely relies on a single drug, praziquantel.
Ibrahim N. Mwangi, Melissa C. Sanchez, Gerald M. Mkoji, Lelo E. Agola, Steven M. Runo, Pauline M. Cupit, Charles Cunningham   +6 more
doaj   +1 more source

Comparison of microscopy and Alamar blue reduction in a larval based assay for schistosome drug screening. [PDF]

, 2010
BACKGROUND: In view of the current widespread use of and reliance on a single schistosomicide, praziquantel, there is a pressing need to discover and develop alternative drugs for schistosomiasis.
Bickle, Quentin D, Mansour Nuha R., Nuha R Mansour, Mansour, Nuha R, Bickle Quentin D., Nuha R. Mansour, Quentin D Bickle, Quentin D. Bickle   +7 more
core   +1 more source

Application of RNAi to Genomic Drug Target Validation in Schistosomes. [PDF]

, 2015
Concerns over the possibility of resistance developing to praziquantel (PZQ), has stimulated efforts to develop new drugs for schistosomiasis. In addition to the development of improved whole organism screens, the success of RNA interference (RNAi) in ...
Bickle, Quentin D, Bickle, Quentin D., Carruthers, Ian M, Gilbert, Ian H, Ian H Gilbert, Nuha R. Mansour (146895), Andrew L. Hopkins (146939), Jérémy Besnard (741480), Hopkins, Andrew L, Gilbert, Ian H., Guidi, Alessandra, Quentin D. Bickle (146947), Ian H. Gilbert (146934), Alessandra Guidi (146927), Mansour, Nuha R., Paveley, Ross A., Alessandra Guidi, Ross A Paveley, Ian M Carruthers, Carruthers, Ian M., Jérémy Besnard, Quentin D Bickle, Paveley, Ross A, Besnard, Jérémy, Nuha R Mansour, Ross A. Paveley (146889), Mansour, Nuha R, Hopkins, Andrew L., Andrew L Hopkins, Ian M. Carruthers (741479)   +29 more
core   +1 more source

The benefits of multidisciplinary collaboration in the successful management of two complex feline cases

Australian Veterinary Journal, EarlyView.
Despite a frequent misconception that behavioural concerns are diagnoses of exclusion, medical conditions and behavioural disorders are frequently inter‐related. In human medicine, the ‘multidisciplinary team’ approach (MDTA) is considered the most efficacious way of managing patients with complex and chronic health conditions.
BE Bollaert, JM Ley, HE Zulch
wiley   +1 more source

Uptake of mass drug administration programme for schistosomiasis control in Koome Islands, Central Uganda. [PDF]

, 2015
INTRODUCTION: Schistosomiasis is one of the neglected tropical diseases targeted for elimination in Uganda through the Mass Drug Administration (MDA) programme.
Nuwaha, Fred, Bagonza, James, Fred Nuwaha, James Bagonza (716006), Tuhebwe Doreen, Yeka, Adoke, Doreen Tuhebwe, Yeka Adoke, Elliott Alison M., Elizabeth Ekirapa Kiracho (716007), Kiracho Elizabeth Ekirapa, Bagonza James, Kiracho, Elizabeth Ekirapa, Doreen Tuhebwe (716005), Nuwaha Fred, Alison M Elliott, Alison M. Elliott (114054), Adoke Yeka, Elliott, Alison M, Elizabeth Ekirapa Kiracho, Adoke Yeka (18017), Tuhebwe, Doreen, James Bagonza, Fred Nuwaha (169425)   +23 more
core   +1 more source

Co-crystals of Praziquantel: Discovery by Network-Based Link Prediction

, 2021
In this study, co-crystals for Praziquantel (PZQ), an anthelmintic drug used to treat schistosomiasis, are predicted with network-based link prediction.
Elias, Vlieg, Paul, Tinnemans, Valérie, Dupray, Jan-Joris, Devogelaer, Hugo, Meekes, Maxime D., Charpentier, Joop H., ter Horst, Arnoud, Tijink, Gérard, Coquerel, Karen, Johnston, Rene, de Gelder   +10 more
core   +1 more source

Tapeworm testing: Coprological and antibody‐based approaches across colic types in a German equine hospital population

Equine Veterinary Education, EarlyView.
Summary Background The association between tapeworm infection and equine colic is established, but gaps remain regarding specific colic types. Objectives To assess the relationship between tapeworm test results and equine colic types: The study aimed to determine if ileocaecal disorders (IC) are more frequently associated with Anoplocephala spp ...
K. L. Adamasky, K. Drozdzewska, P. Schmitz, N. Peczak, K. L. Lightbody, J. B. Matthews, M. K. Nielsen, R. Merle, G. von Samson‐Himmelstjerna, H. Gehlen   +9 more
wiley   +1 more source

Life Course Malaria Exposure and SARS‐CoV‐2 Seroepidemiology in Ugandan Adolescents: A Longitudinal Study Nested in a Birth Cohort

Tropical Medicine &International Health, EarlyView.
ABSTRACT Background COVID‐19 has had major global health impacts, yet reported morbidity and mortality have been lower in Africa despite serological evidence of widespread infection. Malaria has been proposed as a potential modifier of susceptibility to and outcomes of SARS‐CoV‐2 infection.
Ludoviko Zirimenya, Doreen Nayebare, Claire Baine, Jacent Nassuuna, Milly Namutebi, Christopher Zziwa, Denis Nsubuga, Fred Kiwudhu, Florence Akello, Josephine Tumusiime, Gloria Oduru, Grace Kabami, Hellen Akurut, Rachel Nakyesige, Agnes Natukunda, Anne Wajja, Lawrence Lubyayi, Simon Kimuda, Gyaviira Nkurunungi, Jennifer Serwanga, Katie J. Doores, Emily L. Webb, Alison M. Elliott   +22 more
wiley   +1 more source