Results 21 to 30 of about 26,897 (178)

Efficacy of praziquantel and artemisinin derivatives for the treatment and prevention of human schistosomiasis: a systematic review and meta-analysis

Parasites & Vectors, 2011
Background Praziquantel has been used as first-line drug for chemotherapy of schistosomiasis since 1984. Besides praziquantel, artemether and artesunate have also been used for the control of this infectious disease since late 1990s.
Zhao Qin-Ping, Guo Yi, Dong Hui-Fen, Liu Rong, Jiang Ming-Sen   +4 more
doaj   +1 more source

Praziquantel decreases fecundity in Schistosoma mansoni adult worms that survive treatment: evidence from a laboratory life-history trade-offs selection study

Infectious Diseases of Poverty, 2017
Background Mass drug administration of praziquantel is the World Health Organization’s endorsed control strategy for schistosomiasis. A decade of annual treatments across sub-Saharan Africa has resulted in significant reductions of infection prevalence ...
Poppy H.L. Lamberton, Christina L. Faust, Joanne P. Webster   +2 more
doaj   +1 more source

Schistosomiasis‐Associated Pulmonary Arterial Hypertension in Brazil: A Call to Action for Enhanced Diagnostic Recognition—2025 Pulmonary Vascular Research Institute Infection in Pulmonary Vascular Disease Consortium Perspectives [PDF]

Pulm Circ
ABSTRACT Schistosomiasis‐associated pulmonary arterial hypertension (Sch‐PAH) is one of the most frequent etiologies of pulmonary arterial hypertension in Brazil and globally. The disease is a complication of hepatosplenic schistosomiasis characterized by portal hypertension, egg deposition, and granuloma formation in the pulmonary arteries leading to ...
Loureiro C, Correa R, Filho R, Graham B, Butrous G, Oliveira R.   +5 more
europepmc   +2 more sources

Study and implementation of urogenital schistosomiasis elimination in Zanzibar (Unguja and Pemba islands) using an integrated multidisciplinary approach [PDF]

, 2012
: BACKGROUND: Schistosomiasis is a parasitic infection that continues to be a major public health problem in many developing countries being responsible for an estimated burden of at least 1.4 million disability-adjusted life years (DALYs) in Africa ...
Albonico, M., Ali, S. M., Ame, S. M., Colley, D. G., Fenwick, A., Gouvras, A., Khamis, I. S., Knopp, S., Mohammed, K. A., Person, B., Rollinson, D., Savioli, L., Utzinger, J.   +12 more
core   +1 more source

The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand

Nature Communications, 2017
Schistosomiasis is caused by infection with the flatworm Schistosoma, and praziquantel is the drug of choice for its treatment. Here, Chan and colleagues identify praziquantel as a ligand for the human serotoninergic 5-HT2B G-protein-coupled receptor ...
John D. Chan, Pauline M. Cupit, Gihan S. Gunaratne, John D. McCorvy, Yang Yang, Kristen Stoltz, Thomas R. Webb, Peter I. Dosa, Bryan L. Roth, Ruben Abagyan, Charles Cunningham, Jonathan S. Marchant   +11 more
doaj   +1 more source

Safety of topical administration of fluralaner plus moxidectin concurrently with praziquantel in cats

Parasites & Vectors, 2018
Background Fluralaner provides efficacy against feline ectoparasites following topical administration. Moxidectin is routinely used to treat gastrointestinal nematode infections and prevent heartworm disease caused by Dirofilaria immitis. Praziquantel is
Feli M. Walther, Petr Fisara, Rainer K. A. Roepke   +2 more
doaj   +1 more source

Efficacy of imidacloprid 10%/moxidectin 1% spot-on formulation (Advocate®) in the prevention and treatment of feline aelurostrongylosis [PDF]

, 2020
Background: In three randomized, controlled laboratory efficacy studies, the efficacy in the prevention of patent infections of a topical combination of imidacloprid 10%/moxidectin 1% (Advocate® spot-on formulation for cats, Bayer Animal Health GmbH ...
Blazejak, Katrin, Deuster, Katrin, Heuer, Lea, McKay-Demeler, Janina, Petry, Gabriele, Pollmeier, Matthias, Samson-Himmelstjerna, Georg von, Schaper, Roland, Schmidt, Holger, Strube, Christina   +9 more
core   +1 more source

Estimation of changes in the force of infection for intestinal and urogenital schistosomiasis in countries with Schistosomiasis Control Initiative-assisted programmes [PDF]

, 2015
The last decade has seen an expansion of national schistosomiasis control programmes in Africa based on large-scale preventative chemotherapy. In many areas this has resulted in considerable reductions in infection and morbidity levels in treated ...
A Garba, AD Barbour, AD Barbour, AJ Fulford, AJ Fulford, Alan Fenwick, Amadou Garba, AP Plaisier, AP Plaisier, ARC Harris, AW Cheever, B Bolker, B Payet, BL Webster, BL Webster, BL Webster, BR Kirkwood, CH King, CH King, D Engels, D Gurarie, DL Smith, E Michael, E Miguel, EK N'Goran, Elisa Bosqué-Oliva, Fiona M. Fleming, G Webbe, GA Macdonald, GE Box, GF Medley, H Laamrani, H Tanaka, Hairston NG, HC Turner, HC Turner, HP Duerr, I Nåsell, I Nåsell, J Utzinger, J Utzinger, James Mwansa, JH Ouma, Joanne P. Webster, JP Webster, JW Rudge, JW Rudge, L Van Etten, LA Tchuem-Tchuenté, LA Tchuem-Tchuenté, Lynsey Blair, M Booth, M Parker, M Tanner, M-G Basáñez, M-G Basáñez, Maria-Gloria Basáñez, ME Woolhouse, Michael D. French, ML Steinauer, Moussa Sacko, MS Chan, MS Chan, MS Chan, N Katz, Narcis B. Kabatereine, NB Kabatereine, NG Hairston, RM Anderson, RM Anderson, RM Anderson, RM Anderson, RM May, Seydou Toure, SJ de Vlas, SM Blower, Team" RDC, Thomas S. Churcher, Ursuline Nyandindi, WHO   +79 more
core   +4 more sources

Praziquantel sensitivity of Kenyan Schistosoma mansoni isolates and the generation of a laboratory strain with reduced susceptibility to the drug

International Journal for Parasitology: Drugs and Drug Resistance, 2014
Schistosomiasis is a neglected tropical disease caused by blood-dwelling flukes of the genus Schistosoma. While the disease may affect as many as 249 million people, treatment largely relies on a single drug, praziquantel.
Ibrahim N. Mwangi, Melissa C. Sanchez, Gerald M. Mkoji, Lelo E. Agola, Steven M. Runo, Pauline M. Cupit, Charles Cunningham   +6 more
doaj   +1 more source

Are we ready for Taenia solium cysticercosis elimination in sub-Saharan Africa? [PDF]

, 2016
The World Health Organization announced in November 2014 at the fourth international meeting on 'the control of neglected zoonotic diseases - from advocacy to action', that intervention tools for eliminating Taenia solium taeniosis/cysticercosis (TSTC ...
Braae, Uffe Christian, Gabriël, Sarah, Johansen, Maria Vang, Magnussen, Pascal, Trevisan, Chiara   +4 more
core   +3 more sources