Results 21 to 30 of about 17,340 (213)

Toward measuring Schistosoma response to praziquantel treatment with appropriate descriptors of egg excretion [PDF]

, 2015
The control of schistosomiasis emphasizes preventive chemotherapy with praziquantel, which aims at decreasing infection intensity and thus morbidity in individuals, as well as transmission in communities.
Xiao-Nong Zhou (92570), Jennifer Keiser, Utzinger, Jürg, Michel Vaillant, King, Charles H., Jean T Coulibaly, Piero L. Olliaro (217564), José Carlos Sousa-Figueiredo (173724), Stefanie Knopp, Katarina Stete (213207), Olliaro, Piero L, Eliézer K. N’Goran (417750), Jean T. Coulibaly (108845), Jennifer Keiser (39606), Xiao-Nong Zhou, Garba, Amadou, Zhou, Xiao-Nong, Aly Landouré, Aly Landouré (264317), Olliaro, Piero L., Amadou Garba (125686), Landouré, Aly, Jürg Utzinger (39609), Stefanie Knopp (108848), Michel Vaillant (39101), Diawara, Aïssatou, Scherrer, Alexandra U, Amadou Garba, Coulibaly, Jean Tenena, Charles H. King (78462), Vaillant, Michel, Piero L Olliaro, Coulibaly, Jean T., Aïssatou Diawara, Scherrer, Alexandra U., King, Charles H, Sousa-Figueiredo, José Carlos, Katarina Stete, Charles H King, Alexandra U Scherrer, N’Goran, Eliézer K., Stete, Katarina, José Carlos Sousa-Figueiredo, Jürg Utzinger, Giovanna Raso, Giovanna Raso (51489), Alexandra U. Scherrer (214775), Raso, Giovanna, Coulibaly, Jean T, Aïssatou Diawara (5654983), Eliézer K N'Goran, Keiser, Jennifer, N'Goran, Eliézer K., Knopp, Stefanie, N'Goran, Eliézer K   +54 more
core   +1 more source

Effect of praziquantel treatment of Schistosoma mansoni during pregnancy on intensity of infection and antibody responses to schistosome antigens: results of a randomised, placebo-controlled trial. [PDF]

, 2009
BACKGROUND: Praziquantel treatment of schistosomiasis during pregnancy was only recommended in 2002; hence the effects of treatment during pregnancy are not fully known. We have therefore evaluated the effects on infection intensity and the immunological
Emojong Nicholas O, Dunne, David W., Mawa, Patrice A, Birgitte J Vennervald, Jones Frances M, Jones, Frances M., Duong, Trinh, Patrice A Mawa, Emojong, Nicholas O., Vennervald, Birgitte J, Mawa Patrice A, Frances M Jones, Alison M Elliott, Trinh Duong, Mpairwe Harriet, Elliott, Alison M, Robert Tweyongyere, Mawa, Patrice A., Mpairwe, Harriet, Emojong, Nicholas O, Dunne, David W, Katunguka-Rwakishaya Eli, Elliott Alison M, Tweyongyere, Robert, David W Dunne, Katunguka-Rwakishaya, Eli, Dunne David W, Elliott, Alison M., Duong Trinh, Vennervald Birgitte J, Nicholas O Emojong, Eli Katunguka-Rwakishaya, Tweyongyere Robert, Jones, Frances M, Harriet Mpairwe   +34 more
core   +1 more source

Whole organism high-content screening by label-free, image-based Bayesian classification for parasitic diseases. [PDF]

, 2012
Sole reliance on one drug, Praziquantel, for treatment and control of schistosomiasis raises concerns about development of widespread resistance, prompting renewed interest in the discovery of new anthelmintics.
Bickle, Quentin D, Bickle, Quentin D., Mansour Nuha R., Gilbert, Ian H, Alex E Benn, Bickle Quentin D., Ian H Gilbert, Nuha R. Mansour (146895), Andrew L. Hopkins (146939), Ivana Mikic (146920), Benn Alex E., Guidi Alessandra, Leo S. Bleicher (146907), Hopkins, Andrew L, Gilbert, Ian H., Bleicher Leo S., Hopkins Andrew L., Guidi, Alessandra, Benn, Alex E., Ivana Mikic, Quentin D. Bickle (146947), Alex E. Benn (146913), Irene Hallyburton (146900), Ian H. Gilbert (146934), Bleicher, Leo S, Alessandra Guidi (146927), Mansour, Nuha R., Paveley, Ross A., Alessandra Guidi, Bleicher, Leo S., Ross A Paveley, Irene Hallyburton, Quentin D Bickle, Hallyburton, Irene, Paveley Ross A., Paveley, Ross A, Mikic Ivana, Nuha R Mansour, Ross A. Paveley (146889), Mansour, Nuha R, Leo S Bleicher, Mikic, Ivana, Hopkins, Andrew L., Andrew L Hopkins, Hallyburton Irene, Gilbert Ian H., Benn, Alex E   +46 more
core   +2 more sources

Resolution of Praziquantel

PLoS Neglected Tropical Diseases, 2011
Praziquantel remains the drug of choice for the worldwide treatment and control of schistosomiasis. The drug is synthesized and administered as a racemate. Use of the pure active enantiomer would be desirable since the inactive enantiomer is associated with side effects and is responsible for the extremely bitter taste of the pill.We have identified ...
Michael Woelfle, Jean-Paul Seerden, Jesse de Gooijer, Kees Pouwer, Piero Olliaro, Matthew H Todd   +5 more
openaire   +4 more sources

Praziquantel: its use in control of schistosomiasis in sub-Saharan Africa and current research needs [PDF]

, 2009
Treatment with praziquantel (PZQ) has become virtually the sole basis of schistosomiasis control in sub-Saharan Africa and elsewhere, and the drug is reviewed here in the context of the increasing rate that it is being used for this purpose. Attention is
Doenhoff, M.J., Southgate, V., Botros, S., Pica-Mattocia, L., Hagan, P., Coles, G., Tchuem, T.C.H.U., Mbaye, A., Engels, D., Cioli, D.   +9 more
core   +1 more source

New approaches to measuring anthelminthic drug efficacy : parasitological responses of childhood schistosome infections to treatment with praziquantel [PDF]

, 2015
By 2020, the global health community aims to control and eliminate human helminthiases, including schistosomiasis in selected African countries, principally by preventive chemotherapy (PCT) through mass drug administration (MDA) of anthelminthics ...
Scherrer, A U, Raso, G, Utzinger, Jürg, Alexandra U. Scherrer, King, Charles H., Coulibaly, Jean T., Walker, Martin, Basanez, MG, Jean T. Coulibaly, Basáñez, M-G, King, CH, Martin Walker, Walker, M, Scherrer, Alexandra U., Sousa-Figueiredo, José Carlos, Katarina Stete, Mabud, Tarub S., Mabud, T, Stete, Katarina, Basáñez, Maria-Gloria, Coulibaly, J T, José Carlos Sousa-Figueiredo, Jürg Utzinger, Maria-Gloria Basáñez, Utzinger, J, Giovanna Raso, Scherrer, AU, Raso, Giovanna, Olliaro, Piero L., Stothard, JR, Stothard, J R, Sousa-Figueiredo, J C, Olliaro, PL, Coulibaly, JT, Sousa-Figueiredo, JC, Stothard, J. Russell, Charles H. King, King, C H, J. Russell Stothard, Tarub S. Mabud, Piero L. Olliaro, Olliaro, P L, Stete, K   +42 more
core   +1 more source

Efficacy and safety of praziquantel, tribendimidine and mebendazole in patients with co-infection of Clonorchis sinensis and other helminths. [PDF]

PLoS Neglected Tropical Diseases, 2014
BackgroundBoth tribendimidine and mebendazole are broad-spectrum drugs for anti-intestinal nematodes. We aim to assess the efficacy and safety of tribendimidine and mebendazole in patients with co-infection of Clonorchis sinensis and other helminths ...
Li-Li Xu, Bin Jiang, Ji-Hui Duan, Shi-Feng Zhuang, Yong-Chun Liu, Shi-Qiao Zhu, Li-Ping Zhang, Hao-Bing Zhang, Shu-Hua Xiao, Xiao-Nong Zhou   +9 more
doaj   +1 more source

Efficacy of praziquantel against Schistosoma mekongi and Opisthorchis viverrini: a randomized, single-blinded dose-comparison trial [PDF]

, 2012
BACKGROUND: Schistosomiasis and opisthorchiasis are of public health importance in Southeast Asia. Praziquantel (PZQ) is the drug of choice for morbidity control but few dose comparisons have been made.
Youthanavanh Vonghachack (148917), Khampheng Phongluxa, Phonepasong Ayé Soukhathammavong (148913), Jennifer Keiser, Utzinger, Jürg, Tanner, M., Odermatt Peter, Leonore Lovis (148903), Utzinger Jürg, Youthanavanh Vonghachack, Peter Odermatt, Hatz, Christoph, Vounatsou Penelope, Vounatsou, P., Phonepasong Ayé Soukhathammavong, Jennifer Keiser (39606), Phongluxa, Khampheng, Sripa, Banchob, Soukhathammavong, Phonepasong Ayé, Ayé Soukhathammavong Phonepasong, Soukhathammavong, P. A., Vonghachack, Youthanavanh, Utzinger, J., Jürg Utzinger (39609), Tanner Marcel, Tippi K Mak, Christoph Hatz (35423), Penelope Vounatsou (49253), Phongluxa Khampheng, Akkhavong, Kongsap, Mak, T. K., Akkhavong Kongsap, Kongsap Akkhavong (148931), Tippi K. Mak (148907), Marcel Tanner (33894), Penelope Vounatsou, Hatz, C., Marcel Tanner, Mak Tippi K., Lovis, L., Mak, Tippi K, Jürg Utzinger, Kongsap Akkhavong, Leonore Lovis, Tanner, Marcel, Vonghachack Youthanavanh, Keiser Jennifer, Odermatt, P., Keiser, J., Odermatt, Peter, Akkhavong, K., Peter Odermatt (148926), Keiser, Jennifer, Hatz Christoph, Lovis, Leonore, Vonghachack, Y., Khampheng Phongluxa (148910), Lovis Leonore, Vounatsou, Penelope, Christoph Hatz, Phongluxa, K.   +60 more
core   +1 more source

Transcriptional responses of in vivo praziquantel exposure in schistosomes identifies a functional role for calcium signalling pathway member CamKII. [PDF]

PLoS Pathogens, 2013
Treatment for clinical schistosomiasis has relied centrally on the broad spectrum anthelmintic praziquantel; however, there is limited information on its mode of action or the molecular response of the parasite.
Hong You, Donald P McManus, Wei Hu, Michael J Smout, Paul J Brindley, Geoffrey N Gobert   +5 more
doaj   +1 more source

Integrated analysis of innate, Th1, Th2, Th17, and regulatory cytokines identifies changes in immune polarisation following treatment of human schistosomiasis. [PDF]

, 2012
BACKGROUND:  Schistosomiasis elicits cross-regulatory immune responses, but it is unclear how antihelminthic treatment affects this balance. This study integrates data on 13 cytokines elicited by 3 schistosome to examine how praziquantel treatment alters
Rujeni, N, Nausch, N, Mitchell, KM, Mutapi, Francisca, Appleby, Laura J, Midzi, Nicholas, Rujeni, Nadine, Bourke, Claire D, Mduluza, Takafira, Nausch, Norman, Appleby, LJ, Mduluza, T, Midzi, N, Mutapi, F, Bourke, CD, Mitchell, Kate M   +15 more
core   +1 more source