Results 11 to 20 of about 23,001 (237)

Efficacy and Safety of Moxidectin, Synriam, Synriam-Praziquantel versus Praziquantel against Schistosoma haematobium and S. mansoni Infections: A Randomized, Exploratory Phase 2 Trial. [PDF]

PLoS Neglected Tropical Diseases, 2016
BACKGROUND:Schistosomiasis affects millions of people, yet treatment options are limited. The antimalarial Synriam (piperaquine 150 mg/arterolane 750 mg) and the anthelminthic moxidectin revealed promising antischistosomal properties in preclinical or ...
Beatrice Barda, Jean T Coulibaly, Maxim Puchkov, Jörg Huwyler, Jan Hattendorf, Jennifer Keiser   +5 more
doaj   +3 more sources

Praziquantel, mefloquine-praziquantel, and mefloquine-artesunate-praziquantel against Schistosoma haematobium: a randomized, exploratory, open-label trial. [PDF]

PLoS Neglected Tropical Diseases, 2014
BackgroundTreatment and morbidity control of schistosomiasis relies on a single drug, praziquantel. Hence, there is a pressing need to develop additional therapeutics against schistosomiasis.
Jennifer Keiser, Kigbafori D Silué, Lukas K Adiossan, Nicaise A N'Guessan, N'Chou Monsan, Jürg Utzinger, Eliézer K N'Goran   +6 more
doaj   +2 more sources

Postoperative Prophylaxis of Cystic Echinococcosis with Albendazole and Praziquantel: A Retrospective Cohort Study. [PDF]

Biomedicines
Popova-Daskalova G, Kostadinov K, Eneva K, Masarlieva A, Vuchev D, Uchikov A, Aleksova L, Nikolov N, Nedkova T.   +8 more
europepmc   +4 more sources

Spinal Cord Schistosomiasis: A Rare and Severe Presentation of a Common Disease-A Case Report and Review of Literature. [PDF]

Clin Case Rep
ABSTRACT Spinal cord schistosomiasis (SCS) is a rare but potentially disabling manifestation of Schistosoma mansoni infection caused by ectopic deposition of parasite eggs within the spinal cord via Batson's vertebral venous plexus, resulting in granulomatous inflammation and neurological injury.
Shemsu ES, Atnafu TA, Azerefegne EF, Aliye IA.   +3 more
europepmc   +2 more sources

Longitudinal changes and risk factors of Opisthorchis viverrini infection after selective praziquantel treatment: evidence from urine antigen assay and fecal examination in an endemic community in Northeast Thailand. [PDF]

PLoS One
Kopolrat KY, Boueroy P, Kammoolkon R, Pitaksakulrat O, Yasaka P, Worasith C, Wongphutorn P, Eamudomkarn C, Wangboon C, Watwiengkam N, Promkhwan W, Sithithaworn P.   +11 more
europepmc   +3 more sources

The Anthelmintic Activity of Praziquantel Analogs Correlates with Structure-Activity Relationships at TRPMPZQ Orthologs. [PDF]

, 2023
The anthelmintic drug praziquantel remains a key clinical therapy for treating various diseases caused by parasitic flatworms. The parasite target of praziquantel has remained undefined despite longstanding usage in the clinic, although a candidate ion ...
Rohr, Claudia M, Sprague, Daniel J, Harris, Jade L, Marchant, Jonathan S, Park, Sang-Kyu, Lundström-Stadelmann, Britta, Maillard, David, Spangenberg, Thomas, Kaethner, Marc   +8 more
core   +2 more sources

Efficacy and safety of praziquantel in preschool-aged children in an area co-endemic for Schistosoma mansoni and S. haematobium [PDF]

, 2012
BACKGROUND: In sub-Saharan Africa the recommended strategy to control schistosomiasis is preventive chemotherapy. Emphasis is placed on school-aged children, but in high endemicity areas, preschool-aged children are also at risk, and hence might need ...
N'Gbesso, Y. K., N'Goran, E. K., Coulibaly, J. T., Knopp, S., Jennifer Keiser, Eliézer K. N'Goran (108853), Keiser, J., Utzinger, J., Jürg Utzinger (39609), Jean T Coulibaly, Yve K N'gbesso, Stefanie Knopp (108848), Stefanie Knopp, Yve K. N'Gbesso (113126), Eliézer K N'Goran, Jean T. Coulibaly (108845), Jennifer Keiser (39606), Jürg Utzinger   +17 more
core   +1 more source

IMMUNOLOGICAL AND HEMATOLOGICAL CHANGES AFTER PRAZIQUANTEL TREATMENT IN DEN INDUCED HEPATIC NEOPLASIA IN RATS [PDF]

Assiut Veterinary Medical Journal, 1993
Praziquantel, the commonly used anti--schistosomal drug, was investigated for hepatic carcinogenesis promoting potential using Diethylnitrosamine (DEN) - induced hepatic neoplasia in rats as a model in our study. Fity rats were given a daily dose of 5 mg/
M.T. SHATA, M. TAHA, A. SH. SEDDEK
doaj   +1 more source

Dynamics of Schistosoma haematobium egg output and associated infection parameters following treatment with praziquantel in school-aged children [PDF]

, 2012
BACKGROUND: Praziquantel is the drug of choice in preventive chemotherapy targeting schistosomiasis. Increasing large-scale administration of praziquantel requires monitoring of drug efficacy to detect early signs of development of resistance.
Lohourignon Laurent K, Krauth, Stefanie J., Utzinger, Jürg, Coulibaly, Jean T., Jean T Coulibaly, Katarina Stete, Stefanie Knopp, Utzinger Jürg, N’Goran, Eliézer K., Stete, Katarina, Winfried V Kern, Lohourignon, Laurent K., Ivan Müller, Jürg Utzinger, Hattendorf Jan, Stete Katarina, Stefanie J Krauth, Coulibaly Jean T, Krauth Stefanie J, Müller Ivan, Laurent K Lohourignon, Müller, Ivan, N’Goran Eliézer K, Kern Winfried V, Hattendorf, Jan, N'Goran, Eliézer K., Knopp, Stefanie, Kern, Winfried V., Knopp Stefanie, Eliézer K N’Goran, Jan Hattendorf   +30 more
core   +1 more source

Low Praziquantel Treatment Coverage for Schistosoma mansoni in Mayuge District, Uganda, Due to the Absence of Treatment Opportunities, Rather Than Systematic Non-Compliance

Tropical Medicine and Infectious Disease, 2018
The World Health Organization (WHO) recommends praziquantel mass drug administration (MDA) to control schistosomiasis in endemic regions. We aimed to quantify recent and lifetime praziquantel coverage, and reasons for non-treatment, at an individual ...
Moses Adriko, Christina L. Faust, Lauren V. Carruthers, Arinaitwe Moses, Edridah M. Tukahebwa, Poppy H. L. Lamberton   +5 more
doaj   +1 more source