Results 11 to 20 of about 19,502 (213)

Efficacy and Safety of Moxidectin, Synriam, Synriam-Praziquantel versus Praziquantel against Schistosoma haematobium and S. mansoni Infections: A Randomized, Exploratory Phase 2 Trial. [PDF]

PLoS Neglected Tropical Diseases, 2016
BACKGROUND:Schistosomiasis affects millions of people, yet treatment options are limited. The antimalarial Synriam (piperaquine 150 mg/arterolane 750 mg) and the anthelminthic moxidectin revealed promising antischistosomal properties in preclinical or ...
Beatrice Barda, Jean T Coulibaly, Maxim Puchkov, Jörg Huwyler, Jan Hattendorf, Jennifer Keiser   +5 more
doaj   +3 more sources

Praziquantel, mefloquine-praziquantel, and mefloquine-artesunate-praziquantel against Schistosoma haematobium: a randomized, exploratory, open-label trial. [PDF]

PLoS Neglected Tropical Diseases, 2014
BackgroundTreatment and morbidity control of schistosomiasis relies on a single drug, praziquantel. Hence, there is a pressing need to develop additional therapeutics against schistosomiasis.
Jennifer Keiser, Kigbafori D Silué, Lukas K Adiossan, Nicaise A N'Guessan, N'Chou Monsan, Jürg Utzinger, Eliézer K N'Goran   +6 more
doaj   +2 more sources

Empirical therapy for hepatic lesions in suspected clonorchiasis: a comparative efficacy analysis of Albendazole and Praziquantel [PDF]

Frontiers in Pharmacology
BackgroundClonorchiasis frequently presents as intrahepatic space-occupying lesions, posing a diagnostic challenge due to the low sensitivity of fecal examination.
Ya-zhao Cao, Ya-zhao Cao, Peng-zhen Guo, Yu-feng Zhang, Wen-yu Li, Qi-fa Shen, Zhi-hui Li, Zi-ying Lei, Jun-feng Chen, Jing Zhang   +9 more
doaj   +2 more sources

Raw Whitebait as a Probable Source of Human <i>Diplogonoporus balaenopterae</i> Infection in Non-Coastal Area: A Case Report. [PDF]

J Gen Fam Med
ABSTRACT We describe a case of a man in his late 20s who presented with symptoms of diarrhea, abdominal pain, and passage of string‐like materials following the consumption of raw whitebait. Stool analysis was negative for eggs and parasites. However, a worm segment corroborated by subsequent genetic sequencing confirmed infection with Diplogonoporus ...
Hirayama Y, Sato H, Kamiyama K, Hiramoto S, Kimura A, Ito A, Yoshida K, Horiguchi N, Kawai-Kowase K.   +8 more
europepmc   +2 more sources

Factors influencing feline antiparasitic prescriptions by veterinarians and demographics across parts of the UK. [PDF]

Vet Rec Open
Abstract Background Antiparasitic drugs used in companion animals may persist in the environment, contributing to ecological contamination and raising One Health concerns. Understanding behavioural patterns of veterinarians’ prescription is essential for development of effective antiparasitic stewardship programmes. Methods A survey of 29 questions was
Hobbs RE, Duszak-Kowal A.
europepmc   +2 more sources

Optimal single sampling time-point for monitoring of praziquantel exposure in children

Scientific Reports, 2021
Praziquantel pharmacokinetics studies in schistosomiasis infected children are scarce partly due to the challenges/complexity of intensive blood sampling in the target population. This study was aimed to investigate the optimal single sampling time-point
Rajabu Hussein Mnkugwe, Eliford Ngaimisi Kitabi, Safari Kinung’hi, Appolinary A. R. Kamuhabwa, Omary Mashiku Minzi, Eleni Aklillu   +5 more
doaj   +1 more source

Chromatographic Quantification of Ivermectin and Pranziquantel in the Tablets Using Stability Indicating RP-HPLC Method [PDF]

Pharmaceutical Sciences, 2019
Background: A new stability indicating RP-HPLC based assay method was developed to quantify ivermectin and praziquantel simultaneously and applied effectively to tablets.
Naga Venkata Suresh Kumar Devaka, Vallabhaneni Madhusudhan Rao   +1 more
doaj   +1 more source

Potential cost-effectiveness of schistosomiasis treatment for reducing HIV transmission in Africa--the case of Zimbabwean women. [PDF]

PLoS Neglected Tropical Diseases, 2013
Epidemiological data from Zimbabwe suggests that genital infection with Schistosoma haematobium may increase the risk of HIV infection in young women. Therefore, the treatment of Schistosoma haematobium with praziquantel could be a potential strategy for
Martial L Ndeffo Mbah, Eric M Poolman, Katherine E Atkins, Evan W Orenstein, Lauren Ancel Meyers, Jeffrey P Townsend, Alison P Galvani   +6 more
doaj   +1 more source

Uptake of preventive treatment for intestinal schistosomiasis among school children in Jinja district, Uganda: a cross sectional study. [PDF]

PLoS ONE, 2013
BACKGROUND: In Uganda, the current national health sector strategic and investment plan underscores schistosomiasis as one of the diseases targeted for elimination by the year 2015.
Simon Muhumuza, Annette Olsen, Anne Katahoire, Fred Nuwaha   +3 more
doaj   +1 more source

Preformulation and Long-Term Stability Studies of an Optimized Palatable Praziquantel Ethanol-Free Solution for Pediatric Delivery

Pharmaceutics, 2023
To date, the treatment for cysticercosis and neurocysticercosis consists of a single oral intake of praziquantel (5–10 mg/kg), which since it is only available as tablets, hinders its administration to pediatric patients.
Giselle Bedogni, Paula Garcia, Katia Seremeta, Nora Okulik, Claudio Salomon   +4 more
doaj   +1 more source