Parasites & Vectors, 2011 Background Praziquantel has been used as first-line drug for chemotherapy of schistosomiasis since 1984. Besides praziquantel, artemether and artesunate have also been used for the control of this infectious disease since late 1990s.
Zhao Qin-Ping +4 more
doaj +1 more source
Pharmacokinetic study of praziquantel enantiomers and its main metabolite R-trans-4-OH-PZQ in plasma, blood and dried blood spots in Opisthorchis viverrini-infected patients [PDF]
, 2016 Praziquantel (PZQ) is the treatment of choice for infections with the liver fluke Opisthorchis viverrini, a major health problem in Southeast Asia. However, pharmacokinetic (PK) studies investigating the disposition of PZQ enantiomers (R- and S-PZQ) and ...
Jennifer Keiser +15 more
core +1 more source
Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis
Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley +2 more sources
Infectious Diseases of Poverty, 2017 Background Mass drug administration of praziquantel is the World Health Organization’s endorsed control strategy for schistosomiasis. A decade of annual treatments across sub-Saharan Africa has resulted in significant reductions of infection prevalence ...
Poppy H.L. Lamberton +2 more
doaj +1 more source
Enhancing control of schistosomiasis in Niger : assessing morbidity in preschool-aged children, praziquantel treatment efficacy and cost implication for control [PDF]
, 2013 Background: Schistosomiasis, accounted among the neglected tropical diseases (NTDs), represents a major public health problem, particularly in Africa, where more than 95% of all the cases of the world are currently concentrated.
Garba, Amadou
core +1 more source
The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand
Nature Communications, 2017 Schistosomiasis is caused by infection with the flatworm Schistosoma, and praziquantel is the drug of choice for its treatment. Here, Chan and colleagues identify praziquantel as a ligand for the human serotoninergic 5-HT2B G-protein-coupled receptor ...
John D. Chan +11 more
doaj +1 more source
Parasites & Vectors, 2018 Background Fluralaner provides efficacy against feline ectoparasites following topical administration. Moxidectin is routinely used to treat gastrointestinal nematode infections and prevent heartworm disease caused by Dirofilaria immitis. Praziquantel is
Feli M. Walther +2 more
doaj +1 more source
Impossibility of the treatment of inoperable liver multicystic echinococcosis due to adverse reactions to antihelminitics [PDF]
Vojnosanitetski Pregled, 2009 Introduction. In some cases of multicystic forms of liver echinococcal disease, the advanced method for treatment of cystic echinococcosis faces great problems relating to the final outcome of the treatment. Case report.
Mikić Dragan +6 more
doaj +1 more source
Российский паразитологический журнал, 2023 The purpose of the research is to study the efficacy of new multicomponent drugs for dogs and cats against arachnoentomosis and helminthosis.Materials and methods. The efficacy of new four-component Insacar Total C Plus Drops for Dogs and Insacar Total K
N. V. Makhvatova
doaj +1 more source
Sustaining control of Schistosomiasis mansoni in western Côte d'Ivoire : results from a SCORE study, one year after initial praziquantel administration [PDF]
, 2016 The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) has launched several large-scale trials to determine the best strategies for gaining and sustaining control of schistosomiasis and transitioning toward elimination.
Eveline Hürlimann +35 more
core +1 more source