Results 31 to 40 of about 23,001 (237)

Co-crystals of Praziquantel: Discovery by Network-Based Link Prediction [PDF]

, 2021
In this study, co-crystals for Praziquantel (PZQ), an anthelmintic drug used to treat schistosomiasis, are predicted with network-based link prediction.
Elias, Vlieg, Paul, Tinnemans, Valérie, Dupray, Jan-Joris, Devogelaer, Hugo, Meekes, Maxime D., Charpentier, Joop H., ter Horst, Arnoud, Tijink, Gérard, Coquerel, Karen, Johnston, Rene, de Gelder   +10 more
core   +2 more sources

Efficacy of praziquantel and artemisinin derivatives for the treatment and prevention of human schistosomiasis: a systematic review and meta-analysis

Parasites & Vectors, 2011
Background Praziquantel has been used as first-line drug for chemotherapy of schistosomiasis since 1984. Besides praziquantel, artemether and artesunate have also been used for the control of this infectious disease since late 1990s.
Zhao Qin-Ping, Guo Yi, Dong Hui-Fen, Liu Rong, Jiang Ming-Sen   +4 more
doaj   +1 more source

Efficacy of praziquantel against Schistosoma mekongi and Opisthorchis viverrini: a randomized, single-blinded dose-comparison trial [PDF]

, 2012
BACKGROUND: Schistosomiasis and opisthorchiasis are of public health importance in Southeast Asia. Praziquantel (PZQ) is the drug of choice for morbidity control but few dose comparisons have been made.
Youthanavanh Vonghachack (148917), Khampheng Phongluxa, Phonepasong Ayé Soukhathammavong (148913), Jennifer Keiser, Utzinger, Jürg, Tanner, M., Odermatt Peter, Leonore Lovis (148903), Utzinger Jürg, Youthanavanh Vonghachack, Peter Odermatt, Hatz, Christoph, Vounatsou Penelope, Vounatsou, P., Phonepasong Ayé Soukhathammavong, Jennifer Keiser (39606), Phongluxa, Khampheng, Sripa, Banchob, Soukhathammavong, Phonepasong Ayé, Ayé Soukhathammavong Phonepasong, Soukhathammavong, P. A., Vonghachack, Youthanavanh, Utzinger, J., Jürg Utzinger (39609), Tanner Marcel, Tippi K Mak, Christoph Hatz (35423), Penelope Vounatsou (49253), Phongluxa Khampheng, Akkhavong, Kongsap, Mak, T. K., Akkhavong Kongsap, Kongsap Akkhavong (148931), Tippi K. Mak (148907), Marcel Tanner (33894), Penelope Vounatsou, Hatz, C., Marcel Tanner, Mak Tippi K., Lovis, L., Mak, Tippi K, Jürg Utzinger, Kongsap Akkhavong, Leonore Lovis, Tanner, Marcel, Vonghachack Youthanavanh, Keiser Jennifer, Odermatt, P., Keiser, J., Odermatt, Peter, Akkhavong, K., Peter Odermatt (148926), Keiser, Jennifer, Hatz Christoph, Lovis, Leonore, Vonghachack, Y., Khampheng Phongluxa (148910), Lovis Leonore, Vounatsou, Penelope, Christoph Hatz, Phongluxa, K.   +60 more
core   +2 more sources

Efficacy and safety of praziquantel, tribendimidine and mebendazole in patients with co-infection of Clonorchis sinensis and other helminths. [PDF]

PLoS Neglected Tropical Diseases, 2014
BackgroundBoth tribendimidine and mebendazole are broad-spectrum drugs for anti-intestinal nematodes. We aim to assess the efficacy and safety of tribendimidine and mebendazole in patients with co-infection of Clonorchis sinensis and other helminths ...
Li-Li Xu, Bin Jiang, Ji-Hui Duan, Shi-Feng Zhuang, Yong-Chun Liu, Shi-Qiao Zhu, Li-Ping Zhang, Hao-Bing Zhang, Shu-Hua Xiao, Xiao-Nong Zhou   +9 more
doaj   +1 more source

Does the presence of praziquantel-related adverse events affect the health community's perception toward the mass chemopreventive program in the highest prevalence area of Schistosomiasis in Indonesia? Study in Dodolo village, Napu Valley, Central Sulawesi

Gaceta Sanitaria, 2021
Objective: This study was to determine the relationship between a praziquantel-related adverse event with the health community perception to chemopreventive of Schistosomiasis in Dodolo village, Napu Valley, Central Sulawesi.
Ayu Sekarani Damana Putri, T. Vera Diana, Rahma Daris, Fitri Afriana, Serli Hatul Hidayat   +4 more
doaj   +1 more source

Integrated analysis of innate, Th1, Th2, Th17, and regulatory cytokines identifies changes in immune polarisation following treatment of human schistosomiasis. [PDF]

, 2012
BACKGROUND:  Schistosomiasis elicits cross-regulatory immune responses, but it is unclear how antihelminthic treatment affects this balance. This study integrates data on 13 cytokines elicited by 3 schistosome to examine how praziquantel treatment alters
Rujeni, N, Nausch, N, Mitchell, KM, Mutapi, Francisca, Appleby, Laura J, Midzi, Nicholas, Rujeni, Nadine, Bourke, Claire D, Mduluza, Takafira, Nausch, Norman, Appleby, LJ, Mduluza, T, Midzi, N, Mutapi, F, Bourke, CD, Mitchell, Kate M   +15 more
core   +1 more source

Pharmacokinetic study of praziquantel enantiomers and its main metabolite R-trans-4-OH-PZQ in plasma, blood and dried blood spots in Opisthorchis viverrini-infected patients [PDF]

, 2016
Praziquantel (PZQ) is the treatment of choice for infections with the liver fluke Opisthorchis viverrini, a major health problem in Southeast Asia. However, pharmacokinetic (PK) studies investigating the disposition of PZQ enantiomers (R- and S-PZQ) and ...
Jennifer Keiser, Urs Duthaler, Jörg Huwyler, Meister, Isabel, Jana Kovac, Odermatt, Peter, Kovac, Jana, Vanobberghen, Fiona, Peter Odermatt, Somphou Sayasone, Fiona Vanobberghen, Huwyler, Jörg, Sayasone, Somphou, Keiser, Jennifer, Isabel Meister, Duthaler, Urs   +15 more
core   +2 more sources

Praziquantel decreases fecundity in Schistosoma mansoni adult worms that survive treatment: evidence from a laboratory life-history trade-offs selection study

Infectious Diseases of Poverty, 2017
Background Mass drug administration of praziquantel is the World Health Organization’s endorsed control strategy for schistosomiasis. A decade of annual treatments across sub-Saharan Africa has resulted in significant reductions of infection prevalence ...
Poppy H.L. Lamberton, Christina L. Faust, Joanne P. Webster   +2 more
doaj   +1 more source

Praziquantel (Droncit) is effective against diplostomosis of grasscarp Ctenopharyngodon idella and silver carp Hypophthalmichthys molitrix [PDF]

, 1991
In laboratory experiments praziquantel (Droncit) effectively destroyed metacercariae of Diplostomum spathaceum (s. l.) parasitizing the eye lens of grasscarp Ctenopharyngodon idella and silver carp Hypophthalmichthys molitrix.
Molnár, Kálmán, Székely, Csaba
core   +1 more source

Individual and spatial heterogeneity of praziquantel efficacy against Schistosoma mansoni within the context of repeated mass drug administration. [PDF]

Parasit Vectors
Iacovidou MA, Reitzug F, Winter S, Enzaru A, Asiimwe E, Nambatya J, Nakato A, Semakula M, Nabatte B, Kabatereine NB, Chami GF.   +10 more
europepmc   +4 more sources