Results 41 to 50 of about 34,738 (218)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Research on tool tip wear detection and life prediction based on an improved L1PS model
Advances in Mechanical EngineeringTool wear is a critical factor that directly impacts product performance, making accurate and timely detection essential for ensuring machining quality.
Ruizhi Li +6 more
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Journal of Health (JOH), 2019 Packed Red cells (PRC) merupakan sediaan produk darah yang tercacat paling banyak digunakan pada transfusi darah. Indikasi penggunaan PRC adalah untuk menaikan kadar hemoglobin pada pasein. 1 unit PRC dapat menaikkan kadar hematokrit 3-5 %.
Wiwit Sepvianti +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Ideological Transformation of the PRC: Parallels with Late Socialism in the USSR
Сравнительная политика, 2020 Most sinologists assume that ideology is a set of values and ideas which reflect reality in a more or less precise way. While studying ideology of PRC they focus on the literal sense of ideological narratives.
V. A. Skosyrev
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
PRC’S MILITARY-INDUSTRIAL COMPLEX UNDER XI JINPING
Контуры глобальных трансформаций: политика, экономика, право, 2017 The article is dedicated to the achievements and problems of the Chinese military-industrial complex and its role in the economy building during the Xi Jinping` s term (2012–2017).
P. B. Kamennov
doaj +1 more source
Scientific Reports, 2023 When entering the oviduct for fertilisation, spermatozoa come into contact with the oviduct fluid (OF) and can bind to luminal epithelial cells in the isthmus to form a sperm reservoir.
Coline Mahé +7 more
doaj +1 more source