Results 61 to 70 of about 6,492 (168)
Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity
Advanced Science, Volume 13, Issue 46, 17 August 2026.We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu +17 more
wiley +1 more source
Clinical Cardiology, Volume 49, Issue 8, August 2026.This study retrospectively analyzed the characteristics of blood pressure rhythm after emergency PCI for patients with anterior STEMI, discovering the burden of disrupted BP circadian rhythm. The reverse dipper BP rhythm may serve as an independent factor of MACE.
Yangge Shao +4 more
wiley +1 more source
t(1;2)(p36;p21) THADA/PRDM16 [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2018 Review on t(1;2)(p36;p21) translocations, with data on clinics, and the genes involved.
openaire +2 more sources
PRDM16 suppresses HIF-targeted gene expression in kidney cancer
Journal of Experimental Medicine, 2020 Analysis of transcriptomic data demonstrates extensive epigenetic gene silencing of the transcription factor PRDM16 in renal cancer. We show that restoration of PRDM16 in RCC cells suppresses in vivo tumor growth. RNaseq analysis reveals that PRDM16 imparts a predominantly repressive effect on the RCC transcriptome including suppression of the gene ...
Anirban Kundu +14 more
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Prdm3 and Prdm16 are H3K9me1 Methyltransferases Required for Mammalian Heterochromatin Integrity [PDF]
Cell, 2012 Heterochromatin serves important functions, protecting genome integrity and stabilizing gene expression programs. Although the Suv39h methyltransferases (KMTs) are known to ensure pericentric H3K9me3 methylation, the mechanisms that initiate and maintain mammalian heterochromatin organization remain elusive. We developed a biochemical assay and used in
Pinheiro, I. +13 more
openaire +3 more sources
BiomoleculesWe previously reported that PRDM16 mediated the improvement in body composition in testosterone (T)-treated hypogonadal men by shifting adipogenesis to myogenesis.
Siresha Bathina +7 more
doaj +1 more source
Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.CCR1 expression is significantly elevated in adipose tissue of obese individuals. Systemic and adipocyte‐specific Ccr1 deletion promotes fat browning via cAMP/PKA/CREB activation and M2 macrophage polarisation, protecting against obesity. Pharmacological blockade of CCR1 suppresses obesity progression, highlighting its potential as a novel target for ...
Suili Cai +9 more
wiley +1 more source
Acta Physiologica, Volume 242, Issue 8, August 2026.ABSTRACT Objectives Human islets are widely researched to understand pathophysiological mechanisms leading to diabetes. Sex, age, and body mass index (BMI) are key donor traits influencing islet function, which is also regulated by an intricate network of microRNAs.
Wilson K. M. Wong +18 more
wiley +1 more source
Gene expression changes in the secondary palate and mandible of Prdm16 −/− mice [PDF]
Cell and Tissue Research, 2012 Loss of Prdm16 expression in the mouse leads to a complete cleft of the secondary palate. We have now determined changes in gene expression in the secondary palates of Prdm16(-/-) fetuses in an attempt to reveal the mechanism(s) leading to the failure of palate closure in these mice.
Dennis R, Warner +3 more
openaire +2 more sources
The malate–aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes
The FEBS Journal, Volume 293, Issue 15, Page 4489-4507, August 2026.Brown fat cells burn lipids within their mitochondria to generate heat. This process involves two energy “shuttles,” one of which is naturally blocked during heat production. We found that the second shuttle (MASh) is not required to generate heat. However, when MASh is disabled, the fatty acids meant for fuel are instead converted back into stored fat.
Michaela Veliova +12 more
wiley +1 more source