Results 71 to 80 of about 6,492 (168)

t(1;3)(p36;q21) RPN1/PRDM16 [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2018
Review on t(1;3)(p36;q21) translocations, with data on clinics, and the genes involved.
openaire   +2 more sources

Overexpression of PRDM16 attenuates acute kidney injury progression: genetic and pharmacological approaches

MedComm
Acute kidney injury (AKI) presents as a condition marked by a sudden and rapid decrease in kidney function over a short timeframe, resulting from diverse causes. As a transcription factor, PR domain‐containing 16 (PRDM16), has recently been implicated in
Xiaozhou Li, Fang Xu, Pan Zhang, Liufeng Mao, Yong Guo, Huiling Li, Yuxing Xie, Yijian Li, Yingjun Liao, Junxiang Chen, Donghai Wu, Dongshan Zhang   +11 more
doaj   +1 more source

Vertical Growth of Facial Soft Tissues: A Longitudinal Three‐Dimensional Facial Growth Study

Orthodontics &Craniofacial Research, Volume 29, Issue 4, Page 649-658, August 2026.
ABSTRACT Objective This longitudinal cohort study aimed to assess changes in vertical facial landmarks in individuals aged 10 to 18 years and identify sex differences in growth patterns. Materials and Methods One hundred and one individuals (males, n = 56; females, n = 45) were observed.
Signe Silinevica, Amir Nassereldine, Gundega Jakobsone, Jinjun Xiong   +3 more
wiley   +1 more source

t(1;1)(p36;q41) DUSP10/PRDM16 [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2018
Review on t(1;1)(p36;q41) DUSP10/PRDM16 translocations, with data on clinics, and the genes involved.
openaire   +2 more sources

Discovery of PRDM16‐Mediated TRPA1 Induction as the Mechanism for Low Tubulo‐Interstitial Fibrosis in Diabetic Kidney Disease

Advanced Science
The pathogenesis of Diabetic kidney disease(DKD) involves pathological changes in both tubulo‐interstitium and the glomerulus. Surprisingly, tubulo‐interstitial fibrosis (TIF), does not develop significantly until the late stage of DKD.
Fang Xu, Hongwei Jiang, Xiaozhou Li, Jian Pan, Huiling Li, Luxiang Wang, Pan Zhang, Junxiang Chen, Shuangfa Qiu, Yuxin Xie, Yijian Li, Dongshan Zhang, Zheng Dong   +12 more
doaj   +1 more source

Precision medicine for atherosclerotic cardiovascular disease: Integrative genomics maps risk loci and AI‐predicted functional consequences

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
Genomic SEM of five ASCVD traits in > 3.8 million individuals identified 347 risk variants, including 19 novel loci. Integrating fine‐mapping and TWAS prioritized causal genes and revealed endothelial cell enrichment in vascular tissues. AI modelling shows the DCLRE1B mutation destabilizes the protein, impairing DNA repair and transcription.
Liwan Fu, Xiaodi Han, Qin Liu, Yuquan Wang, Yue‐Qing Hu   +4 more
wiley   +1 more source

PRDM16::SKI is a predictor of aberrant expression of the short variant of PRDM16 in pediatric acute myeloid leukemia

Abstract The RNA-sequencing data from the Japanese Children’s Cancer Group (JCCG)’s AML-05 study was re-analyzed to clarify the mechanisms related to high PRDM16 expressions, which is independently associated with adverse outcomes. Results showed that 19 of 139 patients presented with out-of-frame PRDM16::SKI fusions.
Norio Shiba, Masahiro Yoshitomi, Tomoya Komori, Junji Ikeda, Kenichi Yoshida, Shin-ichi Tsujimoto, Yusuke Saito, Yusuke Okuno, satoru ide, Yusuke Hara, Genki Yamato, Wataru Nakamura, Tomoko Kawai, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, etsuko ishikita, Taeko Kaburagi, Masanobu Takeuchi, Kentaro Ohki, Akira Shimada, Motohiro Kato, Junko Takita, Daisuke Tomizawa, Keizo Horibe, Takashi Taga, Souichi Adachi, Akio Tawa, Satoru Miyano, Shuichi Ito, Seishi Ogawa, Yasuhide Hayashi   +31 more
openaire   +1 more source

Refinement of 1p36 Alterations Not Involving PRDM16 in Myeloid and Lymphoid Malignancies

PLoS ONE, 2011
Fluorescence in situ hybridization was performed to characterize 81 cases of myeloid and lymphoid malignancies with cytogenetic 1p36 alterations not affecting the PRDM16 locus. In total, three subgroups were identified: balanced translocations (N = 27) and telomeric rearrangements (N = 15), both mainly observed in myeloid disorders; and unbalanced non ...
Francois P Duhoux, Geneviève Ameye, Virginie Lambot, Christian Herens, Frédéric Lambert, Sophie Raynaud, Iwona Wlodarska, Lucienne Michaux, Catherine Roche-Lestienne, Elise Labis, Sylvie Taviaux, Elise Chapiro, Florence Nguyen-Khac, Stéphanie Struski, Sophie Dobbelstein, Nicole Dastugue, Eric Lippert, Frank Speleman, Nadine Van Roy, An De Weer, Katrina Rack, Pascaline Talmant, Steven Richebourg, Francine Mugneret, Isabelle Tigaud, Marie-Joëlle Mozziconacci, Sophy Laibe, Nathalie Nadal, Christine Terré, Jeanne-Marie Libouton, Anabelle Decottignies, Miikka Vikkula, Hélène A Poirel, Groupe Francophone de Cytogénétique Hématologique (GFCH), Belgian Cytogenetic Group for Hematology and Oncology (BCG-HO)   +34 more
openaire   +6 more sources

Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation

Nature Communications, 2017
The transcriptional co-activator Prdm16 regulates browning of white adipose tissue (WAT). Here, the authors show that Prdm16 interacts with the transcription factor Hlx, which is stabilized in response to β3-adrenergic signaling, to increase thermogenic ...
Lei Huang, Dongning Pan, Qingbo Chen, Lihua J. Zhu, Jianhong Ou, Martin Wabitsch, Yong-Xu Wang   +6 more
doaj   +1 more source

Soybean‐Derived Exosome‐Like Nanovesicles Regulate Lipid Metabolism via Mitochondrial Biogenesis and UCP1/PGC‐1α Mediated Thermogenesis

Food Frontiers, Volume 7, Issue 4, July 2026.
Soybean‐derived exosome‐like nanovesicles suppress lipid accumulation of adipocytes via UCP1/PGC‐1α mediated thermogenesis pathway and boosting mitochondrial function. ABSTRACT Obesity has become an important public health concern in modern society. Plant‐derived exosome‐like nanovesicles are emerging as candidates for obesity intervention.
Zhenzhu Zhu, Luyuan Ni, Mingwei Gao, Qian Yang, Changli Zhang, Qin Liu   +5 more
wiley   +1 more source